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View Structure Prediction Details

Protein: DCP2
Organism: Saccharomyces cerevisiae
Length: 970 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCP2.

Description E-value Query
Range
Subject
Range
DCP2 - Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure fr...
DCP2_YEAST - m7GpppN-mRNA hydrolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCP2 PE=1 SV=1
0.0 [1..970] [1..970]
DCP2_MOUSE - mRNA-decapping enzyme 2 OS=Mus musculus GN=Dcp2 PE=1 SV=1
2.0E-61 [14..238] [8..242]
gi|15451577 - gi|15451577|gb|AAK98701.1|AC069158_13 Putative ABC transporter [Oryza sativa]
4.0E-57 [24..245] [114..342]
DCP2_SCHPO - mRNA decapping complex subunit 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dcp2 PE=1...
dcp2 - mRNA decapping complex subunit Dcp2
1.0E-54 [14..257] [7..255]
gi|19069226, gi|... - gi|19074584|ref|NP_586090.1| putative protein with Mut T domain (Nudix hydrolase family) [Encephalit...
gi|19074584 - gi|19074584|ref|NP_586090.1| putative protein with Mut T domain (Nudix hydrolase family) [Encephalit...
3.0E-52 [14..258] [2..232]
CE23761 - WBGene00003582 locus:dcap-2 status:Partially_confirmed SW:O62255 protein_id:CAB05206.2
3.0E-48 [14..200] [172..362]
gi|8163725, gi|8... - gi|8163725|gb|AAF73827.1| unknown [Streptococcus pneumoniae], gi|8163717|gb|AAF73820.1| unknown [Str...
3.0E-33 [107..294] [2..190]
gi|183576435, gi... - gi|183576435|gb|EDT96963.1| MutT/nudix family protein [Streptococcus pneumoniae CDC3059-06], gi|1684...
gi|15901504, gi|... - gi|15901504|ref|NP_346108.1| MutT/nudix family protein [Streptococcus pneumoniae TIGR4], gi|14973161...
gi|25389257 - pir||C95194 MutT/nudix family protein [imported] - Streptococcus pneumoniae (strain TIGR4)
1.0E-26 [67..227] [35..191]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPLRHALE NVTSVDRILE DLLVRFIINC PNEDLSSVER ELFHFEEASW FYTDFIKLMN  60
   61 PTLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.711 a.4.5 "Winged helix" DNA-binding domain
View Download 0.732 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.627 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.650 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.606 a.144.1 PABC (PABP) domain
View Download 0.604 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.598 a.64.1 Saposin
View Download 0.571 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.565 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.558 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.553 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.531 a.126.1 Serum albumin-like
View Download 0.529 a.4.5 "Winged helix" DNA-binding domain
View Download 0.459 a.144.2 Ribosomal protein L20
View Download 0.456 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.450 a.2.7 tRNA-binding arm
View Download 0.442 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.442 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.439 d.6.1 Prion-like
View Download 0.401 a.39.1 EF-hand
View Download 0.392 f.13.1 Family A G protein-coupled receptor-like
View Download 0.388 a.61.1 Retroviral matrix proteins
View Download 0.374 a.64.2 Bacteriocin AS-48
View Download 0.373 a.7.6 Ribosomal protein S20
View Download 0.371 i.1.1 Ribosome and ribosomal fragments
View Download 0.361 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.359 a.4.5 "Winged helix" DNA-binding domain
View Download 0.357 a.85.1 Hemocyanin, N-terminal domain
View Download 0.356 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.348 d.58.17 Metal-binding domain
View Download 0.333 a.24.17 Group V grass pollen allergen
View Download 0.329 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.327 a.5.6 Hypothetical protein MTH1615
View Download 0.324 a.39.1 EF-hand
View Download 0.320 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.315 a.4.5 "Winged helix" DNA-binding domain
View Download 0.311 a.60.1 SAM/Pointed domain
View Download 0.311 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.308 a.158.1 F-box domain
View Download 0.305 a.46.1 Methionine synthase domain
View Download 0.303 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.303 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.302 g.2.2 Neurotoxin B-IV
View Download 0.297 a.2.3 Chaperone J-domain
View Download 0.295 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.292 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.276 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.272 a.144.1 PABC (PABP) domain
View Download 0.271 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.268 a.118.8 TPR-like
View Download 0.266 a.77.1 DEATH domain
View Download 0.266 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.265 d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.264 a.138.1 Multiheme cytochromes
View Download 0.262 a.2.3 Chaperone J-domain
View Download 0.259 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.254 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.247 a.64.1 Saposin
View Download 0.241 a.5.2 UBA-like
View Download 0.236 a.4.1 Homeodomain-like
View Download 0.233 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.232 d.58.8 Viral DNA-binding domain
View Download 0.230 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.228 a.2.7 tRNA-binding arm
View Download 0.228 d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.221 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.220 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.220 a.112.1 Description not found.
View Download 0.218 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.218 a.30.1 ROP protein
View Download 0.218 a.60.1 SAM/Pointed domain
View Download 0.217 a.157.1 Skp1 dimerisation domain-like
View Download 0.212 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.208 a.118.1 ARM repeat
View Download 0.205 a.42.1 MDM2
View Download 0.205 a.61.1 Retroviral matrix proteins
View Download 0.204 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.200 a.3.1 Cytochrome c

Predicted Domain #2
Region A:
Residues: [65-267]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLKIKSFAQL IIKLCPLVWK WDIRVDEALQ QFSKYKKSIP VRGAAIFNEN LSKILLVQGT  60
   61 ESDSWSFPRG KISKDENDID CCIREVKEEI GFDLTDYIDD NQFIERNIQG KNYKIFLISG 120
  121 VSEVFNFKPQ VRNEIDKIEW FDFKKISKTM YKSNIKYYLI NSMMRPLSMW LRHQRQIKNE 180
  181 DQLKSYAEEQ LKLLLGITKE EQI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1mut__
Description: Nucleoside triphosphate pyrophosphorylase (MutT)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [268-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPGRELLNML HTAVQANSNN NAVSNGQVPS SQELQHLKEQ SGEHNQQKDQ QSSFSSQQQP  60
   61 SIFPSLSEPF ANNKNVIPPT MPMANVFMSN PQLFATMNGQ PFAPFPFMLP LTNNSNSANP 120
  121 IPTPVPPNFN APPNPMAFGV PNMHNLSGPA VSQPFSLPPA PLPRDSGYSS SSPGQLLDIL 180
  181 NSKKPDSNVQ SSKKPKLKIL QRGTDLNSIK QNNNDETAHS NSQALLDLLK KPTSSQKIHA 240
  241 S

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.75
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [509-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPDTSFLPND SVSGIQDAEY EDFESSSDEE VETARDERNS LNVDIGVNVM PSEKDSRRSQ  60
   61 KEKPRNDASK TNLNASAES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.415 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.359 a.64.1 Saposin
View Download 0.356 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.430 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.357 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.338 a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.330 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.328 a.3.1 Cytochrome c
View Download 0.273 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.273 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.261 a.5.6 Hypothetical protein MTH1615
View Download 0.261 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.255 a.4.1 Homeodomain-like
View Download 0.253 a.17.1 p8-MTCP1
View Download 0.248 a.118.11 Cytochrome c oxidase subunit E
View Download 0.232 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.218 a.7.6 Ribosomal protein S20

Predicted Domain #5
Region A:
Residues: [588-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSVEWGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [821-903]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSAKGLLNI LKKNDSTGYP RTEGGPSSEM STSMKRNDAT NNQELDKNST ELLNYLKPKP  60
   61 LNDGYENISN KDSSHELLNI LHG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #6
Region A:
Residues: [595-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKSSPSTQSK QNSSVGMQNK YRQEIHIGDS DAYEVFESSS DEEDGKKLEE LEQTQDNSKL  60
   61 ISQDILKENN FQD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #7
Region A:
Residues: [668-750]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVPHRDMPT ESNKSINETV GLSSTTNTVK KVPKVKILKR GETFASLAND KKAFDSSSNV  60
   61 SSSKDLLQML RNPISSTVSS NQQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #8
Region A:
Residues: [751-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKSQHLSGD EEIMMMLKRN SVSKPQNSEE NASTSSINDA NASELLGMLK QKEKDITAPK  60
   61 QPYNVDSYSQ 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #9
Region A:
Residues: [904-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNSSAFNNN VYATDGYSLA SDNNENSSNK LLNMLQNRSS AINEPNFDVR SNGTSGSNEL  60
   61 LSILHRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.435 a.3.1 Cytochrome c
View Download 0.489 b.40.2 Bacterial enterotoxins
View Download 0.391 a.64.1 Saposin
View Download 0.415 a.112.1 Description not found.
View Download 0.374 a.4.1 Homeodomain-like
View Download 0.366 a.64.1 Saposin
View Download 0.306 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.305 d.15.2 CAD & PB1 domains
View Download 0.300 a.28.1 ACP-like
View Download 0.295 i.1.1 Ribosome and ribosomal fragments
View Download 0.289 a.39.1 EF-hand
View Download 0.281 d.74.2 C-terminal domain of arginine repressor
View Download 0.264 a.60.2 RuvA domain 2-like
View Download 0.247 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.235 a.140.1 LEM domain
View Download 0.228 a.28.1 ACP-like
View Download 0.228 b.71.1 Glycosyl hydrolase domain
View Download 0.220 a.3.1 Cytochrome c
View Download 0.203 d.68.3 SirA-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle