YRC Public Data Repository - Protein Structure Prediction

Protein:	GTO3
Organism:	Saccharomyces cerevisiae
Length:	366 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GTO3.

Description	E-value	Query Range	Subject Range
GTO2_YEAST - Glutathione S-transferase omega-like 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=E... gi\|151941615 - gi\|151941615\|gb\|EDN59978.1\| conserved protein [Saccharomyces cerevisiae YJM789] ECM4 - Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (... gi\|190409888 - gi\|190409888\|gb\|EDV13153.1\| extracellular matrix protein 4 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..365]	[1..369]
gi\|14030631, gi\|... - gi\|23308293\|gb\|AAN18116.1\| At5g45020/K21C13_21 [Arabidopsis thaliana], gi\|15241645\|ref\|NP_199315.1\| ...	0.0	[6..366]	[8..317]
gi\|7469828 - pir\|\|S76960 hypothetical protein - Synechocystis sp. (strain PCC 6803) gi\|1653962, gi\|1... - gi\|1653962\|dbj\|BAA18872.1\| slr0605 [Synechocystis sp. PCC 6803], gi\|16332332\|ref\|NP_443060.1\| hypoth...	0.0	[8..364]	[18..317]
gi\|16762005 - gi\|16762005\|ref\|NP_457622.1\| hypothetical protein STY3413 [Salmonella enterica subsp. enterica serov... gi\|16504308, gi\|... - gi\|25346664\|pir\|\|AG0895 conserved hypothetical protein STY3413 [imported] - Salmonella enterica subs... gi\|29139126, gi\|... - gi\|29143492\|ref\|NP_806834.1\| hypothetical protein t3153 [Salmonella enterica subsp. enterica serovar... gi\|213857436 - gi\|213857436\|ref\|ZP_03384407.1\| hypothetical protein SentesT_19959 [Salmonella enterica subsp. enter... gi\|213586182 - gi\|213586182\|ref\|ZP_03368008.1\| hypothetical protein SentesTyph_34913 [Salmonella enterica subsp. en... gi\|213161087 - gi\|213161087\|ref\|ZP_03346797.1\| hypothetical protein Salmoneentericaenterica_14003 [Salmonella enter...	0.0	[8..366]	[18..320]
lcl\|NC_016856.1_... - [gene=yqjG] [protein=putative glutathione S-transferase] [protein_id=YP_005239413.1] [location=34167... gi\|199605221, gi... - gi\|200388123\|ref\|ZP_03214735.1\| glutathione S-transferase [Salmonella enterica subsp. enterica serov... gi\|194450561, gi... - gi\|194450561\|ref\|YP_002047270.1\| glutathione S-transferase [Salmonella enterica subsp. enterica sero... gi\|197240221, gi... - gi\|197261966\|ref\|ZP_03162040.1\| glutathione S-transferase [Salmonella enterica subsp. enterica serov... gi\|205331193, gi... - gi\|205331193\|gb\|EDZ17957.1\| glutathione S-transferase [Salmonella enterica subsp. enterica serovar 4... gi\|205337878, gi... - gi\|205337878\|gb\|EDZ24642.1\| glutathione S-transferase [Salmonella enterica subsp. enterica serovar H... gi\|16766532, gi\|... - gi\|16766532\|ref\|NP_462147.1\| putative glutathione S-transferase [Salmonella typhimurium LT2], gi\|164...	0.0	[8..366]	[18..320]
gi\|254038274, gi... - gi\|254038274\|ref\|ZP_04872332.1\| conserved hypothetical protein [Escherichia sp. 1_1_43], gi\|22683989... YQJG_ECOLI - Hypothetical protein yqjG - Escherichia coli gi\|85675902, gi\|... - gi\|89109871\|ref\|AP_003651.1\| predicted S-transferase [Escherichia coli str. K-12 substr. W3110], gi\|... gi\|238902212, gi... - gi\|238902212\|ref\|YP_002928008.1\| putative S-transferase [Escherichia coli BW2952], gi\|238863110\|gb\|A... gi\|170082644, gi... - gi\|170082644\|ref\|YP_001731964.1\| S-transferase [Escherichia coli str. K-12 substr. DH10B], gi\|169890... EG12746 - putative S-transferase / Probable GSH transferase; disulfide-bond reductase EG12746 - putative S-transferase / Probable GSH transferase; disulfide-bond reductase	0.0	[8..366]	[18..320]
gi\|25346667 - pir\|\|A97631 hypothetical 37.4K protein in exuR-tdcC intergenic region (o328) [imported] - Agrobacte... gi\|15889536, gi\|... - gi\|15889536\|ref\|NP_355217.1\| hypothetical protein AGR_C_4109 [Agrobacterium tumefaciens str. C58], g...	0.0	[9..364]	[75..377]
gi\|15966123 - gi\|15966123\|ref\|NP_386476.1\| hypothetical protein SMc02708 [Sinorhizobium meliloti 1021] gi\|15075393 - gi\|15075393\|emb\|CAC46949.1\| Conserved hypothetical protein [Sinorhizobium meliloti 1021]	0.0	[9..366]	[19..324]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKSASNNK AEFKRQSSPF REIISADHPI YKPAKGRYWL YVALPCPWAQ RTLITRALKG  60
   61 LAPIIGCSVA HWHLDDKGWR FLEEGDGKTN ERHWFDIAGG ISSVNLNTST PVANIPNNAH 120
  121 RLLVDGTDEP HYGYKRLSDF YFKTKPDYKG RFTVPVLWDL ETCTIVNNES SDIIGIMNSA 180
  181 AFDEFVGEEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.0
Match:	1eemA_
Description:	Class omega GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutathione binding	2.07086805531749	bayes_pls_golite062009
glutathione transferase activity	1.85683051472829	bayes_pls_golite062009
antioxidant activity	1.78836688224506	bayes_pls_golite062009
peroxidase activity	1.62851025934188	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.62851025934188	bayes_pls_golite062009
binding	1.1101496519064	bayes_pls_golite062009
glutathione peroxidase activity	1.08052084417939	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.0279404567142	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
peroxiredoxin activity	0.366096607480921	bayes_pls_golite062009
protein binding	0.341730456502484	bayes_pls_golite062009
selenium binding	0.237008126838281	bayes_pls_golite062009
thioredoxin peroxidase activity	0.163136748643487	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [191-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQVRLVPRSL EAQITEFNSW VYDKINNGVY KAGFAECAEV YEREVTSLFQ YLDKLENLLD  60
   61 KKYTDLEAEY GKNNKDKILD RYFAIGDTLT EADVRLYPTI VRFDVVYHQH FKCNLATIRD 120
  121 DYSRIHTWLK NIYWRHEAFQ RTTDFTHIKL GYTRSQPRVN PIGITPLGPK PDIRPP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
glutathione binding	1.77211489459567	bayes_pls_golite062009
glutathione transferase activity	1.4787810404032	bayes_pls_golite062009
antioxidant activity	1.3961148524753	bayes_pls_golite062009
peroxidase activity	1.2460437903417	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.2460437903417	bayes_pls_golite062009
binding	1.18507788580647	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.699008336089393	bayes_pls_golite062009
glutathione peroxidase activity	0.651680638869122	bayes_pls_golite062009
catalytic activity	0.646676412582618	bayes_pls_golite062009
protein binding	0.376412693567268	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: