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View Structure Prediction Details

Protein: ERG2
Organism: Saccharomyces cerevisiae
Length: 222 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG2.

Description E-value Query
Range		 Subject
Range
ERG2 - C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position...
ERG2_YEAST - C-8 sterol isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG2 PE=1 SV=1
 6.0E-85 [1..222] [1..222]
ERG2_NEUCR - C-8 sterol isomerase OS=Neurospora crassa GN=erg-1 PE=3 SV=2
ERG2_NEUCR - C-8 sterol isomerase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / ...
 6.0E-79 [1..220] [44..255]
ERG2_MAGGR - C-8 sterol isomerase OS=Magnaporthe grisea GN=ERG2 PE=3 SV=1
ERG2_MAGO7 - C-8 sterol isomerase OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) GN=ERG2 PE=3 S...
 9.0E-77 [1..220] [9..220]
ERG2_USTMA - C-8 sterol isomerase OS=Ustilago maydis GN=ERG2 PE=3 SV=1
ERG2_USTMA - C-8 sterol isomerase OS=Ustilago maydis (strain 521 / FGSC 9021) GN=ERG2 PE=3 SV=1
 5.0E-76 [6..220] [24..240]
SGMR1_MOUSE - Sigma non-opioid intracellular receptor 1 OS=Mus musculus GN=Sigmar1 PE=1 SV=1
gi|55250512 - gb|AAH86109.1| Unknown (protein for MGC:98493) [Xenopus laevis]
 2.0E-74 [2..212] [7..210]
SGMR1_RAT - Sigma non-opioid intracellular receptor 1 OS=Rattus norvegicus GN=Sigmar1 PE=1 SV=1
 6.0E-74 [4..212] [11..210]
SGMR1_CAVPO - Sigma non-opioid intracellular receptor 1 OS=Cavia porcellus GN=SIGMAR1 PE=1 SV=1
 9.0E-73 [4..212] [11..210]
gi|123999092, gi... - gi|123999092|gb|ABM87129.1| opioid receptor, sigma 1 [synthetic construct], gi|123987475|gb|ABM83807...
OPRS1 - opioid receptor, sigma 1
HGNC:8157|MIM:60... - non-opioid intracellular receptor 1
gi|109111152 - gi|109111152|ref|XP_001096077.1| PREDICTED: similar to opioid receptor, sigma 1 isoform 1 isoform 5 ...
gi|55633137, gi|... - gi|55633137|ref|XP_520547.1| PREDICTED: opioid receptor, sigma 1 isoform 7 [Pan troglodytes], gi|114...
 1.0E-71 [4..212] [11..210]

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Predicted Domain #1
Region A:
Residues: [1-222] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFFPLLLLI GVVGYIMNVL FTTWLPTNYM FDPKTLNEIC NSVISKHNAA EGLSTEDLLQ  60
   61 DVRDALASHY GDEYINRYVK EEWVFNNAGG AMGQMIILHA SVSEYLILFG TAVGTEGHTG 120
  121 VHFADDYFTI LHGTQIAALP YATEAEVYTP GMTHHLKKGY AKQYSMPGGS FALELAQGWI 180
  181 PCMLPFGFLD TFSSTLDLYT LYRTVYLTAR DMGKNLLQNK KF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
intramolecular oxidoreductase activity 1.47638758343628 bayes_pls_golite062009
binding 0.608869922150629 bayes_pls_golite062009
catalytic activity 0.403492961582325 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle