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View Structure Prediction Details

Protein: MLH1
Organism: Saccharomyces cerevisiae
Length: 769 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLH1.

Description E-value Query
Range
Subject
Range
gi|460627 - gi|460627|gb|AAA16835.1| Mlh1p
0.0 [1..769] [1..769]
gi|19387852, gi|... - gi|19387852|ref|NP_081086.1| MutL protein homolog 1 [Mus musculus], gi|18255308|gb|AAH21815.1| MutL ...
0.0 [2..769] [5..760]
MLH1 - mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
gi|157928134, gi... - gi|157928839|gb|ABW03705.1| mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [synthetic c...
0.0 [2..769] [5..756]
MLH1_RAT - DNA mismatch repair protein Mlh1 OS=Rattus norvegicus GN=Mlh1 PE=2 SV=1
0.0 [2..769] [5..757]
Mlh1-PA - The gene Mlh1 is referred to in FlyBase by the symbol Dmel\Mlh1 (CG11482, FBgn0011659). It is a prot...
0.0 [5..769] [10..664]

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Predicted Domain #1
Region A:
Residues: [1-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLRIKALDA SVVNKIAAGE IIISPVNALK EMMENSIDAN ATMIDILVKE GGIKVLQITD  60
   61 NGSGINKADL PILCERFTTS KLQKFEDLSQ IQTYGFRGEA LASISHVARV TVTTKVKEDR 120
  121 CAWRVSYAEG KMLESPKPVA GKDGTTILVE DLFFNIPSRL RALRSHNDEY SKILDVVGRY 180
  181 AIHSKDIGFS CKKFGDSNYS LSVKPSYTVQ DR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 550.0
Match: 1bknA_
Description: DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [213-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRTVFNKSVA SNLITFHISK VEDLNLESVD GKVCNLNFIS KKSISPIFFI NNRLVTCDLL  60
   61 RRALNSVYSN YLPKGNRPFI YLGIVIDPAA VDVNVHPTKR EVRFLSQDEI IEKIANQLHA 120
  121 ELSAIDTSRT FKASSISTNK PESLIPFNDT IESDRNRKSL RQAQVVENSY TTANSQLRKA 180
  181 KR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 550.0
Match: 1bknA_
Description: DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [395-769]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QENKLVRIDA SQAKITSFLS SSQQFNFEGS STKRQLSEPK VTNVSHSQEA EKLTLNESEQ  60
   61 PRDANTINDN DLKDQPKKKQ KLGDYKVPSI ADDEKNALPI SKDGYIRVPK ERVNVNLTSI 120
  121 KKLREKVDDS IHRELTDIFA NLNYVGVVDE ERRLAAIQHD LKLFLIDYGS VCYELFYQIG 180
  181 LTDFANFGKI NLQSTNVSDD IVLYNLLSEF DELNDDASKE KIISKIWDMS SMLNEYYSIE 240
  241 LVNDGLDNDL KSVKLKSLPL LLKGYIPSLV KLPFFIYRLG KEVDWEDEQE CLDGILREIA 300
  301 LLYIPDMVPK VDTSDASLSE DEKAQFINRK EHISSLLEHV LFPCIKRRFL APRHILKDVV 360
  361 EIANLPDLYK VFERC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle