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Protein Overview: Mlh1-PA

General Information:
Name(s) found: Mlh1-PA / FBpp0087867 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Mlh1 is referred to in FlyBase by the symbol Dmel\Mlh1 (CG11482, FBgn0011659). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4057541..4059907. It has the cytological map location 44B8. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: mismatched DNA binding; ATP binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mismatch repair. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 664 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: mismatch repair [ISS]
    Molecular Function: ATP binding [IEA]
    mismatched DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEYLQPGVI RKLDEVVVNR IAAGEIIQRP ANALKELLEN SLDAQSTHIQ VQVKAGGLKL  60
   61 LQIQDNGTGI RREDLAIVCE RFTTSKLTRF EDLSQIATFG FRGEALASIS HVAHLSIQTK 120
  121 TAKEKCGYKA TYADGKLQGQ PKPCAGNQGT IICIEDLFYN MPQRRQALRS PAEEFQRLSE 180
  181 VLARYAVHNP RVGFTLRKQG DAQPALRTPV ASSRSENIRI IYGAAISKEL LEFSHRDEVY 240
  241 KFEAECLITQ VNYSAKKCQM LLFINQRLVE STALRTSVDS IYATYLPRGH HPFVYMSLTL 300
  301 PPQNLDVNVH PTKHEVHFLY QEEIVDSIKQ QVEARLLGSN ATRTFYKQLR LPGAPDLDET 360
  361 QLADKTQRIY PKEMVRTDST EQKLDKFLAP LVKSDSGVSS SSSQEASRLP EESFRVTAAK 420
  421 KSREVRLSSV LDMRKRVERQ CSVQLRSTLK NLVYVGCVDE RRALFQHETR LYMCNTRSFS 480
  481 EELFYQRMIY EFQNCSEITI SPPLPLKELL ILSLESEAAG WTPEDGDKAE LADGAADILL 540
  541 KKAPIMREYF GLRISEDGML ESLPSLLHQH RPCVAHLPVY LLRLATEVDW EQETRCFETF 600
  601 CRETARFYAQ LDWREGATAG FSRWTMEHVL FPAFKKYLLP PPRIKDQIYE LTNLPTLYKV 660
  661 FERC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..348] PSI-BLAST 85.69897 DNA mismatch repair protein MutL
    2 View Details [349..459] PSI-BLAST 30.09691 No description for 2gq0A was found.
    3 View Details [460..584] PSI-BLAST 7.30103 Crystal structure of the MutL C-terminal domain
    4 View Details [585..664] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle