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View Structure Prediction Details

Protein: MGR3
Organism: Saccharomyces cerevisiae
Length: 501 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MGR3.

Description E-value Query
Range
Subject
Range
MGR3_YEAST - Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3 OS=Saccharomyces cerevisiae (s...
MGR3 - Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondria...
0.0 [1..501] [1..501]
SPAP27G11.02 - TPR repeat protein, unknown biological role
YIO2_SCHPO - TPR repeat-containing protein P27G11.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SP...
4.0E-59 [77..235] [31..185]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLQGMRLSQ RLHKRHLFAS KILTWTTNPA HIRHLHDIRP PASNFNTQES APIPESPANS  60
   61 PTRPQMAPKP NLKKKNRSLM YSIIGVSIVG LYFWFKSNSR KQK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [104-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLSAQKVWK EAIWQESDKM DFNYKEALRR YIEALDECDR SHVDLLSDDY TRIELKIAEM  60
   61 YEKLNMLEEA QNLYQELLSR FFEALNVPGK VDESERGEVL RKDLRIL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.06
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.6263282952649 bayes_pls_golite062009
protein binding 0.816793912043238 bayes_pls_golite062009
hydrolase activity 0.63851966218836 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.397405385912849 bayes_pls_golite062009
small conjugating protein ligase activity 0.368200928255565 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [211-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKSLEINKDI ESGKRKLLQH LLLAQEEILS KSPELKEFFE NRKKKLSMVK DINRDPNDDF  60
   61 KTFVSEENIK FDEQGYMILD LEKNSSAWEP FKEEFFTARD LYTAYCLSSK DIAAALSCKI 120
  121 TSVEWMVMAD MPPGQILLSQ A

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.06
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [352-501]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLGSLFYLQA EKLEADLNQL EQKKSKESNQ ELDMGTYIKA VRFVRKNRDL CLERAQKCYD  60
   61 SVIAFAKRNR KIRFHVKDQL DPSIAQSIAL STYGMGVLSL HEGVLAKAEK LFKDSITMAK 120
  121 ETEFNELLAE AEKELEKTTV LKAAKKEGLN 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.06
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle