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View Structure Prediction Details

Protein: HOF1
Organism: Saccharomyces cerevisiae
Length: 669 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOF1.

Description E-value Query
Range
Subject
Range
HOF1 - Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin rin...
CYK2_YEAST - Cytokinesis protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOF1 PE=1 SV=1
2.0E-92 [1..669] [1..669]
IMP2_SCHPO - Septation protein imp2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=imp2 PE=1 SV=1
imp2 - contractile ring protein Imp2
2.0E-71 [4..666] [17..669]
gi|14250231, gi|... - ref|NP_659210.1| myosin, heavy polypeptide 2, skeletal muscle, adult [Mus musculus], gi|14250231|gb...
1.0E-59 [12..478] [987..1484]
gi|6651165 - gi|6651165|gb|AAF22212.1|AF139493_1 syndapin IIab [Rattus norvegicus]
2.0E-58 [6..414] [15..430]
gi|1205991 - gi|1205991|gb|AAB02622.1| nebulin
2.0E-58 [2..665] [2295..3007]
gi|2351219 - gi|2351219|dbj|BAA22067.1| myosin heavy chain [Cyprinus carpio]
5.0E-57 [12..558] [979..1553]
gi|9971579 - gi|9971579|dbj|BAB12571.1| myosin heavy chain [Pennahia argentata]
3.0E-56 [12..558] [975..1549]

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Predicted Domain #1
Region A:
Residues: [1-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYSYEACFW DPNDNGVNIL LGHISQGIRS CDSMILFFKQ RSELEKDYAR RLGAITGKLD  60
   61 KDIGTNMDYG KLNETFNVVL SVEKARAQSH SKQSEILFRQ IYTDTKAFAA NLQARYTTLS 120
  121 GKIERLRMDK FNKKKGCEVL QKKLQDAQIR FRDLQLNENN MIGAKRVEHN KRELLKWESN 180
  181 SQEYKVQLDV LKQEYKASQK FWIHEWAQLS CELQEMENAR ISFLQSKLQQ FATSSMETYI 240
  241 L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 1.90790462185992 bayes_pls_golite062009
binding 1.8819522899151 bayes_pls_golite062009
protein binding 1.62071874398997 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.292726989351706 bayes_pls_golite062009
hydrolase activity 0.147856264761915 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [242-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQTKMDMLTN HLNSFTAADE ISTFSKENGT GRLKHKTSKG DMNSSANWAQ MSSISTTSKK  60
   61 TESYMDNIRK LSSQLKETEN KRKLASIDKY EKPLPSPEVT MATQFRNSTP VIRNETKVVA 120
  121 NPTLSLRSSP VQLQSNVDDS VLRQKPDKPR PIVGEEQLKP DEDSKNPDEK GLMVHKRNQS 180
  181 LSSPSESSSS NPTDFSHIKK RQSMESMTTS VSSMANSIDD SQRFAKSWNS SNRKRKSMSH 240
  241 LQVPSSASSR SDDGGRT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [499-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNSAHNLNED DYNTRRDTST STILFKPPVA VRGTSRGHTH RQSMIMQDSS NPIEDALYEM  60
   61 ERIQSSSKPG TKTGNIMDER GVVRDRGITV TLPIVT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [595-669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEGFPVIEYA KAMYPLIGNE APGLANFHKG DYLLITEIVN KDWYKGEVYD NDRIDRNHRI  60
   61 GLIPYNFIQL LHQGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1ark__
Description: SH3 domain from nebulin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle