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View Structure Prediction Details

Protein: MRPL3
Organism: Saccharomyces cerevisiae
Length: 390 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRPL3.

Description E-value Query
Range
Subject
Range
gi|151946185 - gi|151946185|gb|EDN64416.1| YmL30 [Saccharomyces cerevisiae YJM789]
gi|190408263 - gi|190408263|gb|EDV11528.1| 60S ribosomal protein L3, mitochondrial precursor [Saccharomyces cerevis...
MRPL3 - Mitochondrial ribosomal protein of the large subunit
RM03_YEAST - 54S ribosomal protein L3, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
1.0E-98 [1..390] [1..390]
RNC_BACHD - Ribonuclease 3 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-12...
RNC_BACHD - Ribonuclease 3 OS=Bacillus halodurans GN=rnc PE=3 SV=1
1.0E-57 [91..376] [11..263]
gi|126509385, gi... - gi|153820073|ref|ZP_01972740.1| ribonuclease III [Vibrio cholerae NCTC 8457], gi|126509385|gb|EAZ719...
gi|254845291, gi... - gi|254849586|ref|ZP_05238936.1| ribonuclease III [Vibrio cholerae MO10], gi|254845291|gb|EET23705.1|...
RNC_VIBCH - Ribonuclease 3 OS=Vibrio cholerae GN=rnc PE=3 SV=1
gi|229512326, gi... - gi|229512326|ref|ZP_04401805.1| ribonuclease III [Vibrio cholerae B33], gi|229352291|gb|EEO17232.1| ...
RNC_VIBCM - Ribonuclease 3 OS=Vibrio cholerae serotype O1 (strain M66-2) GN=rnc PE=3 SV=1
gi|229519462, gi... - gi|229519462|ref|ZP_04408905.1| ribonuclease III [Vibrio cholerae RC9], gi|229344151|gb|EEO09126.1| ...
gi|229507479, gi... - gi|229507479|ref|ZP_04396984.1| ribonuclease III [Vibrio cholerae BX 330286], gi|229354984|gb|EEO199...
gi|229606984, gi... - gi|229606984|ref|YP_002877632.1| ribonuclease III [Vibrio cholerae MJ-1236], gi|229369639|gb|ACQ6006...
RNC_VIBCH - Ribonuclease 3 OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=rnc PE=3 ...
gi|153222435, gi... - gi|153222435|ref|ZP_01953169.1| ribonuclease III [Vibrio cholerae MAK 757], gi|124118872|gb|EAY37615...
gi|121590982, gi... - gi|121590982|ref|ZP_01678301.1| ribonuclease III [Vibrio cholerae 2740-80], gi|121547159|gb|EAX57288...
3.0E-56 [117..370] [8..222]
RNC_LISMO - Ribonuclease 3 OS=Listeria monocytogenes GN=rnc PE=3 SV=1
RNC_LISMO - Ribonuclease 3 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=rnc PE=3 SV=1
gi|224501394 - gi|224501394|ref|ZP_03669701.1| ribonuclease III [Listeria monocytogenes FSL R2-561]
5.0E-56 [115..370] [6..226]
RNC_LISIN - Ribonuclease 3 OS=Listeria innocua GN=rnc PE=3 SV=1
RNC_LISIN - Ribonuclease 3 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=rnc PE=3 SV=1
8.0E-56 [115..370] [6..226]
RNC_STRPN - Ribonuclease 3 OS=Streptococcus pneumoniae GN=rnc PE=3 SV=1
RNC_STRPN - Ribonuclease 3 OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=rnc PE=3 SV=1
2.0E-55 [113..369] [1..226]
RNC_STRP2 - Ribonuclease 3 OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) GN=rnc PE=3 SV=1
gi|25289225 - pir||F98012 ribonuclease III (EC 3.1.26.3) [imported] - Streptococcus pneumoniae (strain R6)
RNC_STRR6 - Ribonuclease 3 OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=rnc PE=3 SV=1
gi|147755517, gi... - gi|148998680|ref|ZP_01826119.1| ribonuclease III [Streptococcus pneumoniae SP11-BS70], gi|147755517|...
gi|147925249, gi... - gi|148989271|ref|ZP_01820651.1| ribonuclease III [Streptococcus pneumoniae SP6-BS73], gi|147925249|g...
gi|168575703, gi... - gi|183578209|gb|EDT98737.1| ribonuclease III [Streptococcus pneumoniae MLV-016], gi|168575703|ref|ZP...
RNC_STRP4 - Ribonuclease 3 OS=Streptococcus pneumoniae serotype 19F (strain G54) GN=rnc PE=3 SV=1
3.0E-55 [113..369] [1..226]
RNC_STRPQ - Ribonuclease 3 OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN=rnc PE=3 SV=1
gi|71910251, gi|... - gi|71910251|ref|YP_281801.1| ribonuclease III [Streptococcus pyogenes MGAS5005], gi|71853033|gb|AAZ5...
RNC_STRP1 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M1 GN=rnc PE=1 SV=1
RNC_STRPY - (P66670) Ribonuclease III (EC 3.1.26.3) (RNase III)
RNC_STRP3 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M3 GN=rnc PE=3 SV=1
gi|13621744, gi|... - gi|15674631|ref|NP_268805.1| ribonuclease III [Streptococcus pyogenes M1 GAS], gi|13621744|gb|AAK335...
RNC_STRP8 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M18 GN=rnc PE=3 SV=1
RNC_STRPF - Ribonuclease 3 OS=Streptococcus pyogenes serotype M4 (strain MGAS10750) GN=rnc PE=3 SV=1
RNC_STRP3 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) GN=rnc PE=3 SV=...
RNC_STRP8 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=rnc PE=3 SV=1
RNC_STRPB - Ribonuclease 3 OS=Streptococcus pyogenes serotype M12 (strain MGAS2096) GN=rnc PE=3 SV=1
RNC_STRPC - Ribonuclease 3 OS=Streptococcus pyogenes serotype M12 (strain MGAS9429) GN=rnc PE=3 SV=1
1.0E-54 [113..370] [4..227]
gi|170711273, gi... - gi|170711273|gb|EDT23455.1| ribonuclease III [Clostridium perfringens B str. ATCC 3626], gi|16821064...
gi|170714262, gi... - gi|170714262|gb|EDT26444.1| ribonuclease III [Clostridium perfringens CPE str. F4969], gi|168214195|...
gi|182380899, gi... - gi|182380899|gb|EDT78378.1| ribonuclease III [Clostridium perfringens NCTC 8239], gi|168217005|ref|Z...
gi|182625857, gi... - gi|182625857|ref|ZP_02953623.1| ribonuclease III [Clostridium perfringens D str. JGS1721], gi|177908...
RNC_CLOPE - Ribonuclease 3 OS=Clostridium perfringens (strain 13 / Type A) GN=rnc PE=3 SV=1
RNC_CLOPE - Ribonuclease 3 OS=Clostridium perfringens GN=rnc PE=3 SV=1
2.0E-54 [117..374] [9..231]
gi|15595050, gi|... - gi|2688625|gb|AAC67040.1| ribonuclease III (rnc) [Borrelia burgdorferi B31], gi|15595050|ref|NP_2128...
RNC_BORBU - Ribonuclease 3 OS=Borrelia burgdorferi GN=rnc PE=3 SV=1
5.0E-54 [113..373] [16..244]

Back

Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIVLKRAIA AGMKPFPNST WHWSRTIRPF SQHLSSTCFL QQSSRFTSKR YLHLSTLTQQ  60
   61 EKRFLPESEL AKYKEYYQGL KSTVNEIPES VASKSPSLRT LHKRLQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.627 0.342 translation a.4.5 "Winged helix" DNA-binding domain
View Download 0.510 0.009 structural constituent of ribosome a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.691 0.006 structural constituent of ribosome a.29.2 Bromodomain
View Download 0.713 0.004 structural constituent of ribosome a.4.3 ARID-like
View Download 0.502 0.003 structural constituent of ribosome d.8.1 Urease, gamma-subunit
View Download 0.499 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.495 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.434 N/A N/A a.64.1 Saposin
View Download 0.428 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.424 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.381 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.360 N/A N/A a.1.1 Globin-like
View Download 0.355 N/A N/A a.51.1 Cytochrome c oxidase subunit h
View Download 0.349 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.346 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.339 N/A N/A a.36.1 Signal peptide-binding domain
View Download 0.318 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.314 N/A N/A a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.311 N/A N/A a.24.4 Hemerythrin
View Download 0.303 N/A N/A a.74.1 Cyclin-like
View Download 0.297 N/A N/A a.118.1 ARM repeat
View Download 0.294 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.292 N/A N/A a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.286 N/A N/A a.26.1 4-helical cytokines
View Download 0.286 N/A N/A a.1.1 Globin-like
View Download 0.285 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.284 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.279 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.278 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.276 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.276 N/A N/A a.7.1 Spectrin repeat
View Download 0.274 N/A N/A a.74.1 Cyclin-like
View Download 0.270 N/A N/A a.11.2 Second domain of FERM
View Download 0.267 N/A N/A a.141.1 Frizzled cystein-rich domain
View Download 0.262 N/A N/A a.26.1 4-helical cytokines
View Download 0.262 N/A N/A a.7.1 Spectrin repeat
View Download 0.258 N/A N/A b.34.8 Fumarylacetoacetate hydrolase, FAH, N-terminal domain
View Download 0.254 N/A N/A a.2.7 tRNA-binding arm
View Download 0.249 N/A N/A a.4.12 TrpR-like
View Download 0.247 N/A N/A a.1.1 Globin-like
View Download 0.244 N/A N/A d.189.1 PX domain
View Download 0.242 N/A N/A a.158.1 F-box domain
View Download 0.240 N/A N/A d.58.19 Bacterial exopeptidase dimerisation domain
View Download 0.238 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.234 N/A N/A a.17.1 p8-MTCP1
View Download 0.232 N/A N/A a.29.2 Bromodomain
View Download 0.231 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.225 N/A N/A a.4.1 Homeodomain-like
View Download 0.223 N/A N/A d.52.4 YhbC-like, N-terminal domain
View Download 0.223 N/A N/A a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.222 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.217 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.212 N/A N/A a.1.1 Globin-like
View Download 0.210 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.207 N/A N/A a.118.1 ARM repeat
View Download 0.206 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

Predicted Domain #2
Region A:
Residues: [107-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPNELTYSTL SRCLTCPSAK LPDKINNPTK GAAFVNTVPT NKYLDNHGLN IMGKNLLSYH  60
   61 VTKSIIQKYP RLPTVVLNAA VNAYISEAVL AHIAKYWGIE VETTSVLSRY LKMEPFEFTL 120
  121 GRLKFFNNSL NSKDGIELIT GKNFSETSAL AMSVRSIIAA IWAVTEQKDS QAVYRFIDDH 180
  181 IMSRKLDITK MFQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 1jfzA_
Description: RNase III endonuclease catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of ribosome 6.7575603459566 bayes_pls_golite062009
structural molecule activity 6.24187874355454 bayes_pls_golite062009
RNA binding 5.07736605479017 bayes_pls_golite062009
binding 2.71832019206733 bayes_pls_golite062009
nucleic acid binding 2.45216687077957 bayes_pls_golite062009
protein binding 1.64057905923545 bayes_pls_golite062009
endoribonuclease activity 1.62086478301433 bayes_pls_golite062009
double-stranded RNA binding 1.46317494664076 bayes_pls_golite062009
DNA binding 0.770826702436345 bayes_pls_golite062009
transcription regulator activity 0.661231648959158 bayes_pls_golite062009
mRNA binding 0.404665180963566 bayes_pls_golite062009
cytoskeletal protein binding 0.403469167264307 bayes_pls_golite062009
single-stranded RNA binding 0.35650576095599 bayes_pls_golite062009
RNA helicase activity 0.0112094156505713 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [300-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEQPTRELAM LCRREGLEKP VSKLVAESGR LSKSPVFIVH VFSGEETLGE GYGSSLKEAK  60
   61 ARAATDALMK WYCYEPLAQQ EPVIDPGTVV V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.39794
Match: 1di2A_
Description: Double-stranded RNA-binding protein A, second dsRBD
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle