YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: YML082W
Organism: Saccharomyces cerevisiae
Length: 649 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YML082W.

Description E-value Query
Range
Subject
Range
YML082W - Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fus...
METX_YEAST - Putative cystathionine gamma-synthase YML082W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
0.0 [1..649] [1..649]
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=metB PE=1 SV=1
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=3 SV=1
0.0 [242..646] [5..379]
MCCB_BACSU - Cystathionine gamma-lyase OS=Bacillus subtilis GN=mccB PE=1 SV=1
gi|221324186 - gi|221324186|ref|ZP_03605480.1| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. SMY...
gi|221319905 - gi|221319905|ref|ZP_03601199.1| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. JH6...
gi|221314984 - gi|221314984|ref|ZP_03596789.1| cystathionine beta-lyase [Bacillus subtilis subsp. subtilis str. NCI...
MCCB_BACSU - Cystathionine gamma-lyase OS=Bacillus subtilis (strain 168) GN=mccB PE=1 SV=1
0.0 [242..646] [5..379]
gi|9929259 - gi|9929259|emb|CAC05298.1| cystathionine beta-lyase [Lactobacillus reuteri]
0.0 [242..645] [5..378]
gi|13699175, gi|... - gi|51261011|gb|AAH78869.1| Cystathionase (cystathionine gamma-lyase) [Rattus norvegicus], gi|1403106...
0.0 [235..646] [12..396]
gi|7437091 - pir||D71973 probable cystathionine gamma-synthase - Helicobacter pylori (strain J99)
METB_HELPJ - Cystathionine gamma-synthase OS=Helicobacter pylori (strain J99 / ATCC 700824) GN=metB PE=3 SV=1
0.0 [242..646] [5..379]
gi|188993147, gi... - gi|188993147|ref|YP_001905157.1| Cys/Met metabolism PLP-dependent enzyme [Xanthomonas campestris pv....
0.0 [225..647] [2..397]
METC_LACLM - Cystathionine beta-lyase OS=Lactococcus lactis subsp. cremoris (strain MG1363) GN=metC PE=1 SV=1
METC_LACLA - Cystathionine beta-lyase OS=Lactococcus lactis subsp. lactis GN=metC PE=3 SV=1
METC_LACLC - Cystathionine beta-lyase (EC 4.4.1.8) (CBL) (Beta-cystathionase) (Cysteine lyase) - Lactococcus lact...
METC_LACLA - Cystathionine beta-lyase OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=metC PE=3 SV=1
0.0 [242..645] [6..379]
CGL_MOUSE - Cystathionine gamma-lyase OS=Mus musculus GN=Cth PE=1 SV=1
0.0 [229..646] [7..396]

Back

Predicted Domain #1
Region A:
Residues: [1-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSAQVATEL GQPIPLDTQH AVSVCFPTWK SVISYVEKDP KVLGCLKSGY PRFWIHPSIQ  60
   61 KLRDILIEKY AKENETCFCF PSYRVAKRCR EYVRRKCAHR NGKVRILQLA TAKPINEEQK 120
  121 TWKRECKIAV VFVDGAYENI LKQYWQYTGE IISSRLAEYV LHELFMVEKK SSPAEEKEYI 180
  181 EMRY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [185-509]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRNLNFAFAD RAKELIKKRI ATKVIDKDEH DEEENYHFLA GNQDEQDFQD TFLDSSLNEA  60
   61 NHGEDHDGGI SGEVDSQEEP HNGLVSTIPP EPIEMSTIEE EQSVEEDAGR CALRVCPERD 120
  121 VFLFPSGMAS IFTAHRLLLQ WDSLRLNRSR NGSDVTSSPP NKKTVIFGFP YADTLHVLQE 180
  181 FNETYFLGEG DESSMKELTK ILHSGEQILA VFIETPSNPL LKMGNLLELK RLSELFGFFI 240
  241 IIDETVGGIV NIDGLPFADI VCSSLTKTFS GDSNVIGGSM VLNPQSRVYE FASRFMQLED 300
  301 EYEDLLWCED AIYLERNSRD FIART

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [546-562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETLTNYDMVR CKKEGGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 179.218487
Match: 1qgnA_
Description: Cystathionine gamma-synthase, CGS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 2.29878871754893 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 1.87460342369605 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.80372125032222 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.80372125032222 bayes_pls_golite062009
transferase activity 1.44093490824786 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
cystathionine beta-lyase activity 0.6849039330512 bayes_pls_golite062009
cystathionine gamma-lyase activity 0.505859361763689 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 0.271623203801431 bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity 0.234399054481664 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity 0.0669652799570574 bayes_pls_golite062009
nucleic acid binding 0.013097682076602 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [510-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRINYSTEYL LDKILKPHVG ENKLFKKIYY PNLTSK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [563-649]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGLFSLTFHD EDHAAAFYDN LKLNKGPSLG TNFTLAFPYT LMTYYHELDM AEKFGVERNL  60
   61 LRISVGLESQ SILGKIFQEA IDKTVEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 179.218487
Match: 1qgnA_
Description: Cystathionine gamma-synthase, CGS
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle