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View Structure Prediction Details

Protein: CYB2
Organism: Saccharomyces cerevisiae
Length: 591 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYB2.

Description E-value Query
Range		 Subject
Range
gi|190408190 - gi|190408190|gb|EDV11455.1| L-lactate cytochrome c oxidoreductase [Saccharomyces cerevisiae RM11-1a]
CYB2_YEAST - Cytochrome b2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYB2 PE=1 S...
gi|151946111 - gi|151946111|gb|EDN64342.1| L-lactate cytochrome c oxidoreductase [Saccharomyces cerevisiae YJM789]
CYB2 - Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane ...
 0.0 [1..591] [1..591]
gi|5262950 - gi|5262950|emb|CAB45871.1| cytochrome b2 [Kluyveromyces lactis]
 0.0 [5..588] [2..585]
CYB2_WICAO - Cytochrome b2, mitochondrial OS=Wickerhamomyces anomalus GN=CYB2 PE=1 SV=2
 0.0 [4..588] [2..567]
CYBL_RHOGR - (S)-mandelate dehydrogenase, mitochondrial OS=Rhodotorula graminis PE=1 SV=2
 0.0 [8..567] [6..564]
GLO5_ARATH - Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 OS=Arabidopsis thaliana GN=GLO5 PE=1 SV=1
 0.0 [202..558] [3..354]

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Predicted Domain #1
Region A:
Residues: [1-79] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKYKPLLKI SKNCEAAILR ASKTRLNTIR AYGSTVPKSK SFEQDSRKRT QSWTALRVGA  60
   61 ILAATSSVAY LNWHNGQID

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.321 a.77.1 DEATH domain
View Download 0.347 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.373 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.424 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.281 a.7.7 BAG domain
View Download 0.274 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.232 d.58.17 Metal-binding domain
View Download 0.231 g.39.1 Glucocorticoid receptor-like (DNA-binding domain)
View Download 0.209 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.202 a.46.1 Methionine synthase domain

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the CH-CH group of donors 5.53040931722074 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 4.99876306143789 bayes_pls_golite062009
L-lactate dehydrogenase (cytochrome) activity 4.62364477397179 bayes_pls_golite062009
lactate dehydrogenase activity 4.48836665081946 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor 4.26416137128289 bayes_pls_golite062009
oxidoreductase activity 3.55520438339582 bayes_pls_golite062009
2,4-dienoyl-CoA reductase (NADPH) activity 2.53740821102118 bayes_pls_golite062009
catalytic activity 1.94749091175302 bayes_pls_golite062009
binding 1.13068993839107 bayes_pls_golite062009
(S)-2-hydroxy-acid oxidase activity 1.08257847863105 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor 0.922853827985629 bayes_pls_golite062009
NADH dehydrogenase activity 0.449365788564188 bayes_pls_golite062009
nucleic acid binding 0.428925551338656 bayes_pls_golite062009
protein binding 0.174608759343963 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor 0.0276574257865798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [80-176] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEPKLDMNKQ KISPAEVAKH NKPDDCWVVI NGYVYDLTRF LPNHPGGQDV IKFNAGKDVT  60
   61 AIFEPLHAPN VIDKYIAPEK KLGPLQGSMP PELVCPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10156.0
Match: 1fcbA_
Description: Flavocytochrome b2, C-terminal domain; Flavocytochrome b2, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [177-591] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YAPGETKEDI ARKEQLKSLL PPLDNIINLY DFEYLASQTL TKQAWAYYSS GANDEVTHRE  60
   61 NHNAYHRIFF KPKILVDVRK VDISTDMLGS HVDVPFYVSA TALCKLGNPL EGEKDVARGC 120
  121 GQGVTKVPQM ISTLASCSPE EIIEAAPSDK QIQWYQLYVN SDRKITDDLV KNVEKLGVKA 180
  181 LFVTVDAPSL GQREKDMKLK FSNTKAGPKA MKKTNVEESQ GASRALSKFI DPSLTWKDIE 240
  241 ELKKKTKLPI VIKGVQRTED VIKAAEIGVS GVVLSNHGGR QLDFSRAPIE VLAETMPILE 300
  301 QRNLKDKLEV FVDGGVRRGT DVLKALCLGA KGVGLGRPFL YANSCYGRNG VEKAIEILRD 360
  361 EIEMSMRLLG VTSIAELKPD LLDLSTLKAR TVGVPNDVLY NEVYEGPTLT EFEDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10156.0
Match: 1fcbA_
Description: Flavocytochrome b2, C-terminal domain; Flavocytochrome b2, N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle