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View Structure Prediction Details

Protein: AMD1
Organism: Saccharomyces cerevisiae
Length: 810 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AMD1.

Description E-value Query
Range		 Subject
Range
gi|190408206 - gi|190408206|gb|EDV11471.1| AMP deaminase [Saccharomyces cerevisiae RM11-1a]
AMD1 - AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may ...
gi|151946127 - gi|151946127|gb|EDN64358.1| AMP deaminase [Saccharomyces cerevisiae YJM789]
AMPD_YEAST - AMP deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AMD1 PE=1 SV=2
 0.0 [1..810] [1..810]
gi|194381058, gi... - gi|5922018|gb|AAD56303.1| AMP deaminase isoform L [Homo sapiens], gi|194381058|dbj|BAG64097.1| unnam...
 0.0 [51..797] [48..779]
AMPD2_MOUSE - AMP deaminase 2 OS=Mus musculus GN=Ampd2 PE=1 SV=1
 0.0 [56..797] [47..774]
ada1 - adenosine deaminase Ada1
AMPD_SCHPO - AMP deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ada1 PE=1 SV=2
 0.0 [50..799] [40..764]
AMPD_ARATH - AMP deaminase OS=Arabidopsis thaliana GN=AMPD PE=1 SV=2
 0.0 [43..793] [99..822]

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Predicted Domain #1
Region A:
Residues: [1-240] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNQATQRLN DLSLEPAPSH DEQDGSGLVI DIDQRKIGDE QAGVVVDDET PPLEQQDSHE  60
   61 SLAADSRNAN FSYHENQQLL ENGTKQLALD EHDSHSAILE QPSHSTNCSS SNIAAMNKGH 120
  121 DSADHASQNS GGKPRTLSAS AQHILPETLK SFAGAPVVNK QVRTSASYKM GMLADDASQQ 180
  181 FLDDPSSELI DLYSKVAECR NLRAKYQTIS VQNDDQNPKN KPGWVVYPPP PKPSYNSDTK 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
catalytic activity 1.70199291046899 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.12925526582667 bayes_pls_golite062009
transcription regulator activity 0.867179877821333 bayes_pls_golite062009
nucleic acid binding 0.784495708118775 bayes_pls_golite062009
DNA binding 0.58985393219841 bayes_pls_golite062009
binding 0.568044210518453 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 0.248802326836448 bayes_pls_golite062009
hydrolase activity 0.24275130580417 bayes_pls_golite062009
dihydroorotase activity 0.203044795244555 bayes_pls_golite062009
deaminase activity 0.18698811376434 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.0954028693917728 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [241-293] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVVPVTNKPD AEVFDFTKCE IPGEDPDWEF TLNDDDSYVV HRSGKTDELI AQI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.927 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.843 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.843 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.836 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.821 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.820 0.036 purine nucleotide metabolic process b.34.3 Myosin S1 fragment, N-terminal domain
View Download 0.814 0.036 purine nucleotide metabolic process b.34.9 Tudor/PWWP/MBT
View Download 0.811 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.801 0.036 purine nucleotide metabolic process b.34.3 Myosin S1 fragment, N-terminal domain
View Download 0.798 0.036 purine nucleotide metabolic process d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.796 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.784 0.036 purine nucleotide metabolic process b.34.9 Tudor/PWWP/MBT
View Download 0.782 0.036 purine nucleotide metabolic process b.34.7 DNA-binding domain of retroviral integrase
View Download 0.778 0.036 purine nucleotide metabolic process d.9.1 Interleukin 8-like chemokines
View Download 0.776 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.762 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.757 0.036 purine nucleotide metabolic process d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.752 0.036 purine nucleotide metabolic process d.9.1 Interleukin 8-like chemokines
View Download 0.747 0.036 purine nucleotide metabolic process b.34.1 C-terminal domain of transcriptional repressors
View Download 0.742 0.036 purine nucleotide metabolic process b.34.4 Electron transport accessory proteins
View Download 0.719 0.036 purine nucleotide metabolic process b.34.2 SH3-domain
View Download 0.715 0.036 purine nucleotide metabolic process d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.680 0.036 purine nucleotide metabolic process d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.674 0.036 purine nucleotide metabolic process d.9.1 Interleukin 8-like chemokines
View Download 0.672 0.036 purine nucleotide metabolic process b.34.7 DNA-binding domain of retroviral integrase
View Download 0.658 0.036 purine nucleotide metabolic process b.40.4 Nucleic acid-binding proteins
View Download 0.657 0.036 purine nucleotide metabolic process b.34.5 Translation proteins SH3-like domain
View Download 0.650 0.036 purine nucleotide metabolic process b.34.3 Myosin S1 fragment, N-terminal domain
View Download 0.646 0.036 purine nucleotide metabolic process b.40.4 Nucleic acid-binding proteins
View Download 0.641 0.036 purine nucleotide metabolic process d.50.1 dsRNA-binding domain-like
View Download 0.621 0.036 purine nucleotide metabolic process g.5.1 Midkine
View Download 0.620 0.036 purine nucleotide metabolic process g.27.1 Fibronectin type I module
View Download 0.612 0.036 purine nucleotide metabolic process d.50.1 dsRNA-binding domain-like
View Download 0.596 0.036 purine nucleotide metabolic process b.38.1 Sm-like ribonucleoproteins
View Download 0.591 0.036 purine nucleotide metabolic process g.3.7 Scorpion toxin-like
View Download 0.584 0.036 purine nucleotide metabolic process b.40.4 Nucleic acid-binding proteins
View Download 0.560 0.036 purine nucleotide metabolic process g.41.3 Zinc beta-ribbon
View Download 0.546 0.036 purine nucleotide metabolic process g.28.1 Thyroglobulin type-1 domain
View Download 0.525 0.036 purine nucleotide metabolic process d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.514 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.501 0.036 purine nucleotide metabolic process d.50.1 dsRNA-binding domain-like
View Download 0.484 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.467 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.463 0.036 purine nucleotide metabolic process b.40.2 Bacterial enterotoxins
View Download 0.454 0.036 purine nucleotide metabolic process b.34.5 Translation proteins SH3-like domain
View Download 0.421 0.036 purine nucleotide metabolic process d.17.1 Cystatin/monellin
View Download 0.401 0.036 purine nucleotide metabolic process b.38.2 YhbC-like, C-terminal domain
View Download 0.394 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.391 0.036 purine nucleotide metabolic process d.50.1 dsRNA-binding domain-like
View Download 0.389 0.036 purine nucleotide metabolic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.379 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.374 0.036 purine nucleotide metabolic process b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.364 0.036 purine nucleotide metabolic process d.58.17 Metal-binding domain
View Download 0.359 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.354 0.036 purine nucleotide metabolic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.346 0.036 purine nucleotide metabolic process d.58.3 Protease propeptides/inhibitors
View Download 0.331 0.036 purine nucleotide metabolic process b.72.1 WW domain
View Download 0.327 0.036 purine nucleotide metabolic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.317 0.036 purine nucleotide metabolic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.315 0.036 purine nucleotide metabolic process g.42.1 Ribosomal protein L36
View Download 0.307 0.036 purine nucleotide metabolic process g.59.1 Zinc-binding domain of translation initiation factor 2 beta
View Download 0.307 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.306 0.036 purine nucleotide metabolic process b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.299 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.293 0.036 purine nucleotide metabolic process d.58.8 Viral DNA-binding domain
View Download 0.288 0.036 purine nucleotide metabolic process d.93.1 SH2 domain
View Download 0.285 0.036 purine nucleotide metabolic process g.59.1 Zinc-binding domain of translation initiation factor 2 beta
View Download 0.283 0.036 purine nucleotide metabolic process b.40.4 Nucleic acid-binding proteins
View Download 0.282 0.036 purine nucleotide metabolic process b.38.1 Sm-like ribonucleoproteins
View Download 0.275 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.274 0.036 purine nucleotide metabolic process b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.272 0.036 purine nucleotide metabolic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.272 0.036 purine nucleotide metabolic process g.59.1 Zinc-binding domain of translation initiation factor 2 beta
View Download 0.270 0.036 purine nucleotide metabolic process b.34.5 Translation proteins SH3-like domain
View Download 0.268 0.036 purine nucleotide metabolic process d.58.17 Metal-binding domain
View Download 0.250 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.248 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.248 0.036 purine nucleotide metabolic process d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.247 0.036 purine nucleotide metabolic process g.42.1 Ribosomal protein L36
View Download 0.247 0.036 purine nucleotide metabolic process g.42.1 Ribosomal protein L36
View Download 0.232 0.036 purine nucleotide metabolic process b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.227 0.036 purine nucleotide metabolic process b.72.1 WW domain
View Download 0.213 0.036 purine nucleotide metabolic process d.129.1 TATA-box binding protein-like
View Download 0.208 0.036 purine nucleotide metabolic process d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.206 0.036 purine nucleotide metabolic process d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.202 0.036 purine nucleotide metabolic process b.84.1 Single hybrid motif

Predicted Domain #3
Region A:
Residues: [294-562] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLRDYYLDL EKMISISSDG PAKSFAYRRL QYLEARWNLY YLLNEYQETS VSKRNPHRDF  60
   61 YNVRKVDTHV HHSACMNQKH LLRFIKHKLR HSKDEKVIFR DGKLLTLDEV FRSLHLTGYD 120
  121 LSIDTLDMHA HKDTFHRFDK FNLKYNPIGE SRLREIFLKT NNYIKGTYLA DITKQVIFDL 180
  181 ENSKYQNCEY RISVYGRSLD EWDKLASWVI DNKVISHNVR WLVQIPRLYD IYKKTGIVQS 240
  241 FQDICKNLFQ PLFEVTKNPQ SHPKLHVFL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 35.468521
Match: PF00962
Description: Adenosine/AMP deaminase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [563-810] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRVIGFDSVD DESKVDRRFH RKYPKPSLWE APQNPPYSYY LYYLYSNVAS LNQWRAKRGF  60
   61 NTLVLRPHCG EAGDPEHLVS AYLLAHGISH GILLRKVPFV QYLYYLDQVG IAMSPLSNNA 120
  121 LFLTYDKNPF PRYFKRGLNV SLSTDDPLQF SYTREPLIEE YSVAAQIYKL SNVDMCELAR 180
  181 NSVLQSGWEA QIKKHWIGKD FDKSGVEGND VVRTNVPDIR INYRYDTLST ELELVNHFAN 240
  241 FKRTIEEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.0
Match: 1m7mA_
Description: No description for 1m7mA_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle