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View Structure Prediction Details

Protein: TRM12
Organism: Saccharomyces cerevisiae
Length: 462 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM12.

Description E-value Query
Range		 Subject
Range
TYW2_YEAST - tRNA wybutosine-synthesizing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=T...
gi|151946157 - gi|151946157|gb|EDN64388.1| tRNA methyltransferase [Saccharomyces cerevisiae YJM789]
TRM12 - S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybut...
 0.0 [1..462] [1..462]
TYW23_ARATH - tRNA wybutosine-synthesizing protein 2/3/4 OS=Arabidopsis thaliana GN=At4g04670 PE=2 SV=1
 6.0E-61 [37..457] [663..993]
TRM5_MACFA - tRNA (guanine(37)-N1)-methyltransferase OS=Macaca fascicularis GN=TRMT5 PE=2 SV=1
 3.0E-53 [64..461] [81..471]
gi|7243167 - gi|7243167|dbj|BAA92631.1| KIAA1393 protein [Homo sapiens]
 2.0E-51 [64..461] [72..462]
TRM5_MOUSE - tRNA (guanine(37)-N1)-methyltransferase OS=Mus musculus GN=Trmt5 PE=1 SV=1
 6.0E-51 [64..462] [74..465]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-40 [73..459] [61..466]
ANM3_RAT - Protein arginine N-methyltransferase 3 OS=Rattus norvegicus GN=Prmt3 PE=1 SV=1
 3.0E-36 [84..421] [95..393]

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Predicted Domain #1
Region A:
Residues: [1-226] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDETMPVEF LVSDKRLLKT IKVKLETNGL FVTPIYSDND NKVIKSSIED LNHPLAVEIN  60
   61 NIAGVKARFH ESGNLERSEG HLKHQSNSIT EFTKSFLKDH GLANDKIFLS HLLDHLPLKY 120
  121 TIYPPVVLFN NSTVRSFNHP IWQKAFQLKL FDPNEYYREL LCFLSPGKPS KGTSLHPNNR 180
  181 LLTHLAINNP ITEADVLRRP FNIQPLYGKL IDDSILDDND NTLWEN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [227-462] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQEQLNSSI WCKVIQNGVT QIWSPVFTMF SRGNIKEKKR VLTTFPDICN NDVVDLYAGI  60
   61 GYFTFSYLTK GARTLFAFEL NPWSVEGLKR GLKANGFNKS GNCHVFQESN EMCVQRLTEF 120
  121 LSQNPGFRLR IRHINLGLLP SSKQGWPLAI KLIYLQGASL EKVTMHIHEN VHIDAIEDGS 180
  181 FEKNVIVELD AINESIALIR NRGIKLQFVR SKLERIKTFA PDIWHVCVDV DVIVST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.221849
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
rRNA methyltransferase activity 2.29640050660273 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.533090627724779 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.455449410561251 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.364369105571521 bayes_pls_golite062009
hydrolase activity 0.33020971648583 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle