YRC Public Data Repository - Protein Structure Prediction

Protein:	CNA1
Organism:	Saccharomyces cerevisiae
Length:	553 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNA1.

Description	E-value	Query Range	Subject Range
CNA1 - Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmo... PP2B1_YEAST - Serine/threonine-protein phosphatase 2B catalytic subunit A1 OS=Saccharomyces cerevisiae (strain ATC...	0.0	[1..553]	[1..553]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[36..550]	[73..565]
gi\|55730042 - gi\|55730042\|emb\|CAH91746.1\| hypothetical protein [Pongo abelii] gi\|109075136, gi... - gi\|109075136\|ref\|XP_001108711.1\| PREDICTED: protein phosphatase 3 (formerly 2B), catalytic subunit, ... gi\|19343933, gi\|... - gi\|194688147\|ref\|NP_001124163.1\| protein phosphatase 3, catalytic subunit, alpha isoform isoform 2 [... HGNC:9314\|MIM:11... - phosphatase 3, catalytic subunit, alpha isozyme gi\|168279127, gi... - gi\|168279127\|dbj\|BAG11443.1\| serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform... gi\|197099817 - gi\|197099817\|ref\|NP_001127457.1\| protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isofo...	0.0	[37..535]	[9..483]
gi\|227952, gi\|45... - gi\|4584820\|emb\|CAA40398.2\| serine/threonine specific protein phosphatase [Rattus norvegicus], gi\|227... gi\|74138620, gi\|... - gi\|74219496\|dbj\|BAE29521.1\| unnamed protein product [Mus musculus], gi\|74138620\|dbj\|BAE27131.1\| unna...	0.0	[37..535]	[9..483]
gi\|47523060, gi\|... - gi\|47523060\|ref\|NP_999293.1\| protein phosphatase 3, catalytic subunit, alpha isoform [Sus scrofa], g...	0.0	[37..535]	[9..483]
gi\|17978561 - gi\|17978561\|gb\|AAL47191.1\| calcineurin [Exophiala dermatitidis]	0.0	[19..550]	[11..521]

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Predicted Domain #1

Region A:
Residues: [1-553]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKDLNSSRI KIIKPNDSYI KVDRKKDLTK YELENGKVIS TKDRPIASVP AITGKIPSDE  60
   61 EVFDSKTGLP NHSFLREHFF HEGRLSKEQA IKILNMSTVA LSKEPNLLKL KAPITICGDI 120
  121 HGQYYDLLKL FEVGGDPAEI DYLFLGDYVD RGAFSFECLI YLYSLKLNNL GRFWMLRGNH 180
  181 ECKHLTSYFT FKNEMLHKYD MEVYDACCRS FNVLPLAALM NGQYFCVHGG ISPELKSVED 240
  241 VNKINRFREI PSRGLMCDLL WADPVENYDD ARDGSEFDQS EDEFVPNSLR GCSFAFTFKA 300
  301 SCKFLKANGL LSIIRAHEAQ DAGYRMYKNN KVTGFPSLIT MFSAPNYLDT YHNKAAVLKY 360
  361 EENVMNIRQF HMSPHPYWLP DFMDVFTWSL PFVGEKVTSM LVSILNICSE QELDPESEPK 420
  421 AAEETVKARA NATKETGTPS DEKASSAILE DETRRKALRN KILAIAKVSR MFSVLREESE 480
  481 KVEYLKTMNA GVLPRGALAR GTEGLNETLS TFEKARKEDL INEKLPPSLS EVEQEKIKYY 540
  541 EKILKGAEKK PQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2490.0
Match:	1auiA_
Description:	Protein phosphatase-2B (PP-2B, calcineurin A subunit)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	7.59009048424811	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
structural constituent of muscle	2.91086263632625	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
signal transducer activity	1.08090214431427	bayes_pls_golite062009
molecular transducer activity	1.08090214431427	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
substrate-specific transporter activity	0.528189469950839	bayes_pls_golite062009
calmodulin binding	0.37151341856392	bayes_pls_golite062009
protein transporter activity	0.10469955758282	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: