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View Structure Prediction Details

Protein: VPS33
Organism: Saccharomyces cerevisiae
Length: 691 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS33.

Description E-value Query
Range
Subject
Range
VPS33_YEAST - Vacuolar protein sorting-associated protein 33 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
VPS33 - ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essen...
gi|151940917 - gi|151940917|gb|EDN59299.1| vacuolar sorting protein [Saccharomyces cerevisiae YJM789]
0.0 [1..691] [1..691]
SLY1_DROVI - Protein sly1 homolog OS=Drosophila virilis GN=Slh PE=3 SV=1
0.0 [31..691] [2..644]
gi|1944130 - gi|1944130|dbj|BAA19547.1| hunc18b2 [Homo sapiens]
0.0 [52..578] [22..537]
STXB2_CANLF - Syntaxin-binding protein 2 OS=Canis lupus familiaris GN=STXBP2 PE=2 SV=1
0.0 [39..578] [12..537]
STXB2_MOUSE - Syntaxin-binding protein 2 OS=Mus musculus GN=Stxbp2 PE=1 SV=1
0.0 [52..578] [22..537]
gi|7321218, gi|1... - gi|7321218|emb|CAA73264.2| sec1-like protein [Loligo pealei], gi|13096246|pdb|1FVH|A Chain A, Crysta...
0.0 [42..577] [7..541]

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Predicted Domain #1
Region A:
Residues: [1-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRFWNTKKF SLTNADGLCA TLNEISQNDE VLVVQPSVLP VLNSLLTFQD LTQSTPVRKI  60
   61 TLLDDQLSDD LPSALGSVPQ MDLIFLIDVR TSLRLPPQLL DAAQKHNLSS LHIIYCRWKP 120
  121 SFQNTLEDTE QWQKDGFDLN SKKTHFPNVI ESQLKELSNE YTLYPWDLLP FPQIDENVLL 180
  181 THSLYNMENV NMYYPNLRSL QSATESILVD DMVNSLQSLI FETNSIITNV VSIGNLSKRC 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.9897
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SNARE binding 3.42828022195984 bayes_pls_golite062009
binding 2.63582271791607 bayes_pls_golite062009
syntaxin binding 2.11416428645287 bayes_pls_golite062009
protein binding 1.92978960054246 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [241-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHLLKKRIDE HQTENDLFIK GTLYGERTNC GLEMDLIILE RNTDPITPLL TQLTYAGILD  60
   61 DLYEFNSGIK IKEKDMNFNY KEDKIWNDLK FLNFGSIGPQ LNKLAKELQT QYDTRHKAES 120
  121 VHEIKEFVDS LGSLQQRQAF LKNHTTLSSD VLKVVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.9897
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [397-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEEYGSFNKI LELELEILMG NTLNNDIEDI ILELQYQYEV DQKKILRLIC LLSLCKNSLR  60
   61 EKDYEYLRTF MIDSWGIEKC FQLESLAELG FFTSKTGKTD LHITTSKSTR LQKEYRYISQ 120
  121 WFNTVPIEDE HAADKITNEN DDFSEATFAY SGVVPLTMRL VQMLYDRSIL FHNYSSQQPF 180
  181 ILSREPRVSQ TEDLIEQLYG DSHAIEESIW VPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.9897
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [610-691]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TITKKINASI KSNNRRSIDG SNGTFHAAED IALVVFLGGV TMGEIAIMKH LQKILGKKGI  60
   61 NKRFIIIADG LINGTRIMNS IS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.832 0.023 fungal-type vacuole membrane c.52.2 tRNA splicing endonuclease, C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle