YRC Public Data Repository - Protein Structure Prediction

Protein:	GUF1
Organism:	Saccharomyces cerevisiae
Length:	645 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUF1.

Description	E-value	Query Range	Subject Range
LEPA_GEOKA - Elongation factor 4 OS=Geobacillus kaustophilus GN=lepA PE=3 SV=1 LEPA_GEOKA - Elongation factor 4 OS=Geobacillus kaustophilus (strain HTA426) GN=lepA PE=3 SV=1	805.0	[0..34]	[644..1]
LEPA_BACHD - Elongation factor 4 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 /... LEPA_BACHD - Elongation factor 4 OS=Bacillus halodurans GN=lepA PE=3 SV=1	793.0	[0..34]	[644..1]
LEPA_BACSK - Elongation factor 4 OS=Bacillus clausii (strain KSM-K16) GN=lepA PE=3 SV=1	791.0	[0..34]	[644..1]
LEPA_BACC1 - Elongation factor 4 OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=lepA PE=3 SV=1 gi\|229198447, gi... - gi\|229198447\|ref\|ZP_04325151.1\| GTP-binding protein lepA [Bacillus cereus m1293], gi\|228584950\|gb\|EE...	789.0	[0..34]	[644..1]
gi\|229157933, gi... - gi\|229157933\|ref\|ZP_04286006.1\| GTP-binding protein lepA [Bacillus cereus ATCC 4342], gi\|228625541\|g... gi\|228987570, gi... - gi\|228987570\|ref\|ZP_04147688.1\| GTP-binding protein lepA [Bacillus thuringiensis serovar tochigiensi... gi\|47553986, gi\|... - gi\|47569315\|ref\|ZP_00239999.1\| GTP-binding protein LepA [Bacillus cereus G9241], gi\|47553986\|gb\|EAL1...	788.0	[0..34]	[644..1]
gi\|221319721 - gi\|221319721\|ref\|ZP_03601015.1\| GTP-binding protein LepA [Bacillus subtilis subsp. subtilis str. JH6... gi\|221314799 - gi\|221314799\|ref\|ZP_03596604.1\| GTP-binding protein LepA [Bacillus subtilis subsp. subtilis str. NCI... LEPA_BACSU - Elongation factor 4 OS=Bacillus subtilis (strain 168) GN=lepA PE=3 SV=2 LEPA_BACSU - Elongation factor 4 OS=Bacillus subtilis GN=lepA PE=3 SV=2 gi\|221323999 - gi\|221323999\|ref\|ZP_03605293.1\| GTP-binding protein LepA [Bacillus subtilis subsp. subtilis str. SMY...	788.0	[0..37]	[644..5]
gi\|153196258, gi... - gi\|254829762\|ref\|ZP_05234417.1\| GTP-binding protein LepA [Listeria monocytogenes 10403S], gi\|1531962... gi\|126943486, gi... - gi\|254898355\|ref\|ZP_05258279.1\| GTP-binding protein LepA [Listeria monocytogenes J0161], gi\|15318383... gi\|153179529, gi... - gi\|254936481\|ref\|ZP_05268178.1\| GTP-binding protein LepA [Listeria monocytogenes F6900], gi\|15317952... gi\|153190922, gi... - gi\|254912153\|ref\|ZP_05262165.1\| GTP-binding protein LepA [Listeria monocytogenes J2818], gi\|15319092... gi\|47095432, gi\|... - gi\|47095432\|ref\|ZP_00233042.1\| GTP-binding protein LepA [Listeria monocytogenes str. 1/2a F6854], gi...	787.0	[0..34]	[644..1]
gi\|254757772 - gi\|254757772\|ref\|ZP_05209799.1\| GTP-binding protein LepA [Bacillus anthracis str. Australia 94] gi\|190562059, gi... - gi\|190567068\|ref\|ZP_03019984.1\| GTP-binding protein LepA [Bacillus anthracis Tsiankovskii-I], gi\|190... gi\|254750900 - gi\|254750900\|ref\|ZP_05202939.1\| GTP-binding protein LepA [Bacillus anthracis str. Vollum] gi\|172081533, gi... - gi\|177653251\|ref\|ZP_02935503.1\| GTP-binding protein LepA [Bacillus anthracis str. A0174], gi\|1720815... gi\|254741462 - gi\|254741462\|ref\|ZP_05199149.1\| GTP-binding protein LepA [Bacillus anthracis str. Kruger B] gi\|170707378, gi... - gi\|170707378\|ref\|ZP_02897832.1\| GTP-binding protein LepA [Bacillus anthracis str. A0389], gi\|1701276... gi\|170668645, gi... - gi\|170687450\|ref\|ZP_02878667.1\| GTP-binding protein LepA [Bacillus anthracis str. A0465], gi\|1706686... gi\|167513441, gi... - gi\|167638593\|ref\|ZP_02396869.1\| GTP-binding protein LepA [Bacillus anthracis str. A0193], gi\|1675134... gi\|167634498, gi... - gi\|167634498\|ref\|ZP_02392818.1\| GTP-binding protein LepA [Bacillus anthracis str. A0442], gi\|1675299... gi\|49181141, gi\|... - gi\|49187214\|ref\|YP_030466.1\| GTP-binding protein LepA [Bacillus anthracis str. Sterne], gi\|49181141\|... gi\|165872104, gi... - gi\|165872104\|ref\|ZP_02216744.1\| GTP-binding protein LepA [Bacillus anthracis str. A0488], gi\|1647122... gi\|254736424 - gi\|254736424\|ref\|ZP_05194130.1\| GTP-binding protein LepA [Bacillus anthracis str. Western North Amer... gi\|254721910 - gi\|254721910\|ref\|ZP_05183699.1\| GTP-binding protein LepA [Bacillus anthracis str. A1055] gi\|254684076 - gi\|254684076\|ref\|ZP_05147936.1\| GTP-binding protein LepA [Bacillus anthracis str. CNEVA-9066] LEPA_BACAC - Elongation factor 4 OS=Bacillus anthracis (strain CDC 684 / NRRL 3495) GN=lepA PE=3 SV=1	786.0	[0..34]	[644..1]
gi\|30264390, gi\|... - gi\|30264390\|ref\|NP_846767.1\| GTP-binding protein LepA [Bacillus anthracis str. Ames], gi\|30259048\|gb... gi\|65321692, gi\|... - gi\|65321692\|ref\|ZP_00394651.1\| COG0481: Membrane GTPase LepA [Bacillus anthracis str. A2012], ref\|NP... gi\|47504989, gi\|... - gi\|47529841\|ref\|YP_021190.1\| GTP-binding protein LepA [Bacillus anthracis str. 'Ames Ancestor'], gi\|... LEPA_BACAN - Elongation factor 4 OS=Bacillus anthracis GN=lepA PE=3 SV=1 LEPA_BACAA - Elongation factor 4 OS=Bacillus anthracis (strain A0248) GN=lepA PE=3 SV=1	786.0	[0..34]	[644..1]
LEPA_LISMO - Elongation factor 4 OS=Listeria monocytogenes GN=lepA PE=3 SV=1 LEPA_LISMC - GTP-binding protein lepA OS=Listeria monocytogenes serotype 4b (strain Clip81459) GN=lepA PE=3 SV=1 gi\|254824462 - gi\|254824462\|ref\|ZP_05229463.1\| GTP-binding protein LepA [Listeria monocytogenes FSL J1-194] LEPA_LISMH - Elongation factor 4 OS=Listeria monocytogenes serotype 4a (strain HCC23) GN=lepA PE=3 SV=1 gi\|254852103 - gi\|254852103\|ref\|ZP_05241451.1\| GTP-binding protein LepA [Listeria monocytogenes FSL R2-503] gi\|254873346 - gi\|254873346\|ref\|ZP_05246056.1\| GTP-binding protein LepA [Listeria monocytogenes FSL N1-017] gi\|224501581 - gi\|224501581\|ref\|ZP_03669888.1\| GTP-binding protein LepA [Listeria monocytogenes FSL R2-561] gi\|254879032 - gi\|254879032\|ref\|ZP_05251742.1\| GTP-binding protein LepA [Listeria monocytogenes FSL J2-071] gi\|224500502 - gi\|224500502\|ref\|ZP_03668851.1\| GTP-binding protein LepA [Listeria monocytogenes Finland 1988] LEPA_LISMC - Elongation factor 4 OS=Listeria monocytogenes serotype 4b (strain CLIP80459) GN=lepA PE=3 SV=1 LEPA_LISMF - Elongation factor 4 OS=Listeria monocytogenes serotype 4b (strain F2365) GN=lepA PE=3 SV=1 gi\|254827767, gi... - gi\|254827767\|ref\|ZP_05232454.1\| GTP-binding protein LepA [Listeria monocytogenes FSL N3-165], gi\|153... LEPA_LISMO - Elongation factor 4 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=lepA PE=... gi\|153202407, gi... - gi\|254931414\|ref\|ZP_05264773.1\| GTP-binding protein LepA [Listeria monocytogenes HPB2262], gi\|153202... gi\|47017523, gi\|... - gi\|47094093\|ref\|ZP_00231818.1\| GTP-binding protein LepA [Listeria monocytogenes str. 4b H7858], gi\|4...	785.0	[0..34]	[644..1]

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Predicted Domain #1

Region A:
Residues: [1-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKFRIRPVR HIRCYKRHAY FLRYNHTTTP AQKLQAQIEQ IPLENYRNFS IVAHVDHGKS  60
   61 TLSDRLLEIT HVIDPNARNK QVLDKLEVER ERGITIKAQT CSMFYKDKRT GKNYLLHLID 120
  121 TPGHVDFRGE VSRSYASCGG AILLVDASQG IQAQTVANFY LAFSLGLKLI PVINKIDLNF 180
  181 TDVKQVKDQI VNNFELPEED IIGVSAKTGL NVEELLLPAI IDRIPPPTGR PDKPFRALLV 240
  241 DSWYDAYLGA VLLVNIVDGS VRKNDKVICA QTKEKYEVKD IGIMYPDRTS TGTLKTGQVG 300
  301 YLVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	303.0
Match:	1darA
Description:	ELONGATION FACTOR G IN COMPLEX WITH GDP
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [305-569]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMKDSKEAKI GDTIMHLSKV NETEVLPGFE EQKPMVFVGA FPADGIEFKA MDDDMSRLVL  60
   61 NDRSVTLERE TSNALGQGWR LGFLGSLHAS VFRERLEKEY GSKLIITQPT VPYLVEFTDG 120
  121 KKKLITNPDE FPDGATKRVN VAAFHEPFIE AVMTLPQEYL GSVIRLCDSN RGEQIDITYL 180
  181 NTNGQVMLKY YLPLSHLVDD FFGKLKSVSR GFASLDYEDA GYRISDVVKL QLLVNGNAID 240
  241 ALSRVLHKSE VERVGREWVK KFKEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	303.0
Match:	1darA
Description:	ELONGATION FACTOR G IN COMPLEX WITH GDP
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [570-645]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKSQLYEVVI QARANNKIIA RETIKARRKD VLQKLHASDV SRRKKLLAKQ KEGKKHMKTV  60
   61 GNIQINQEAY QAFLRR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.708	a.25.5	Description not found.
View	Download	0.698	a.8.11	Description not found.
View	Download	0.663	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.662	a.7.6	Ribosomal protein S20
View	Download	0.655	a.64.1	Saposin
View	Download	0.655	a.64.1	Saposin
View	Download	0.640	a.2.8	Eukaryotic DNA topoisomerase I, dispensable insert domain
View	Download	0.558	a.2.8	Eukaryotic DNA topoisomerase I, dispensable insert domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits