YRC Public Data Repository - Protein Structure Prediction

Protein:	NNT1
Organism:	Saccharomyces cerevisiae
Length:	261 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NNT1.

Description	E-value	Query Range	Subject Range
NNT1 - Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determinatio... NNT1_YEAST - Protein N-methyltransferase NNT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NNT1 PE...	4.0E-54	[1..261]	[1..261]
nnt1 - nicotinamide N-methyltransferase Nnt1 NNT1_SCHPO - Protein N-methyltransferase nnt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nnt1 PE=3...	2.0E-39	[1..258]	[1..250]
UBIG_PASMU - 3-demethylubiquinone-9 3-methyltransferase OS=Pasteurella multocida GN=ubiG PE=3 SV=1 UBIG_PASMU - Ubiquinone biosynthesis O-methyltransferase OS=Pasteurella multocida (strain Pm70) GN=ubiG PE=3 SV=1	6.0E-33	[71..260]	[37..229]
gi\|17982052, gi\|... - gi\|17986455\|ref\|NP_539089.1\| ribosomal protein L11 methyltransferase [Brucella melitensis 16M], gi\|1... gi\|25526885 - pir\|\|AF3273 ribosomal protein L11 methyltransferase (EC 2.1.1.-) [imported] - Brucella melitensis (s...	4.0E-31	[10..220]	[9..197]
UBIG_PSEAE - 3-demethylubiquinone-9 3-methyltransferase OS=Pseudomonas aeruginosa GN=ubiG PE=3 SV=1 UBIG_PSEAE - Ubiquinone biosynthesis O-methyltransferase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C...	3.0E-30	[46..260]	[20..219]
gi\|14585877, gi\|... - gi\|42475946\|ref\|NP_963892.1\| hypothetical protein LOC196483 isoform 2 [Homo sapiens], gi\|14585877\|gb...	5.0E-30	[24..244]	[64..286]
gi\|25399411 - pir\|\|E87673 conserved hypothetical protein CC3423 [imported] - Caulobacter crescentus gi\|16127653, gi\|... - gi\|16127653\|ref\|NP_422217.1\| hypothetical protein CC_3423 [Caulobacter crescentus CB15], gi\|13425137... gi\|220965645, gi... - gi\|221236472\|ref\|YP_002518909.1\| ribosomal protein L11 methyltransferase [Caulobacter crescentus NA1...	1.0E-29	[4..220]	[3..198]
gi\|4731342 - gi\|4731342\|gb\|AAD28459.1\|AF127374_14 MitM [Streptomyces lavendulae]	5.0E-29	[15..223]	[5..198]
gi\|165991206, gi... - gi\|166009810\|ref\|ZP_02230708.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar A... gi\|165923694, gi... - gi\|165924634\|ref\|ZP_02220466.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar O... gi\|167400211, gi... - gi\|167400211\|ref\|ZP_02305724.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar A... gi\|166207058, gi... - gi\|166211287\|ref\|ZP_02237322.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar A... gi\|21959882, gi\|... - gi\|22126850\|ref\|NP_670273.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis KIM], gi\|21... gi\|167057080, gi... - gi\|167424231\|ref\|ZP_02315984.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar M... gi\|167419865, gi... - gi\|167419865\|ref\|ZP_02311618.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar O... gi\|229841159, gi... - gi\|229841159\|ref\|ZP_04461318.1\| bifunctional 3-demethylubiquinone-9 3-methyltransferase/2-octaprenyl... UBIG_YERPS - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pseudotuberculosis serotype I (strain IP3295... UBIG_YERPB - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+... gi\|229843264, gi... - gi\|229843264\|ref\|ZP_04463410.1\| bifunctional 3-demethylubiquinone-9 3-methyltransferase/2-octaprenyl... gi\|45440761, gi\|... - gi\|45440761\|ref\|NP_992300.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis biovar Micr... UBIG_YERPY - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPII... gi\|229704005, gi... - gi\|229894120\|ref\|ZP_04509306.1\| bifunctional 3-demethylubiquinone-9 3-methyltransferase/2-octaprenyl... gi\|15979274, gi\|... - gi\|218928374\|ref\|YP_002346249.1\| 3-demethylubiquinone-9 3-methyltransferase [Yersinia pestis CO92], ... UBIG_YERPS - 3-demethylubiquinone-9 3-methyltransferase OS=Yersinia pseudotuberculosis GN=ubiG PE=3 SV=1 UBIG_YERPE - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pestis GN=ubiG PE=3 SV=1 UBIG_YERPG - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=ubiG P... UBIG_YERP3 - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP ... gi\|165938368, gi... - gi\|89104020\|ref\|ZP_01176576.1\| COG2227: 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol met... gi\|149366794, gi... - gi\|149366794\|ref\|ZP_01888828.1\| bifunctional 3-demethylubiquinone-9 3-methyltransferase and 2-octapr... UBIG_YERPA - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=ubiG ... UBIG_YERPP - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pestis (strain Pestoides F) GN=ubiG PE=3 SV=... UBIG_YERPN - Ubiquinone biosynthesis O-methyltransferase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=ubiG...	2.0E-28	[46..257]	[28..225]
gi\|7227291, gi\|1... - gi\|7227291\|gb\|AAF42352.1\| 3-demethylubiquinone-9 3-methyltransferase [Neisseria meningitidis MC58], ... gi\|11256790 - gi\|11256790\|pir\|\|H81015 3-demethylubiquinone-9 3-methyltransferase NMB2030 [imported] - Neisseria me...	3.0E-28	[71..259]	[45..228]

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Predicted Domain #1

Region A:
Residues: [1-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDIESLGEA AGLFEEPEDF LPPPPKPHFA EYQRSHITKE SKSDVKDIKL RLVGTSPLWG  60
   61 HLLWNAGIYT ANHLDSHPEL IKGKTVLELG AAAALPSVIC ALNGAQMVVS TDYPDPDLMQ 120
  121 NIDYNIKSNV PEDFNNVSTE GYIWGNDYSP LLAHIEKIGN NNGKFDLIIL SDLVFNHTEH 180
  181 HKLLQTTKDL LAEKGQALVV FSPHRPKLLE KDLEFFELAK NEFHLVPQLI EMVNWKPMFD 240
  241 EDEETIEVRS RVYAYYLTHE K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.39794
Match:	1f3lA_
Description:	Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-methyltransferase activity	1.4114792557994	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	1.07629237539972	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
methyltransferase activity	1.06467956103007	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.04881630872808	bayes_pls_golite062009
transcription regulator activity	0.978540537169703	bayes_pls_golite062009
DNA binding	0.905031018963259	bayes_pls_golite062009
nucleic acid binding	0.848300230574943	bayes_pls_golite062009
histone methyltransferase activity	0.718593815666209	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.488694756043017	bayes_pls_golite062009
RNA methyltransferase activity	0.473668177706488	bayes_pls_golite062009
N-methyltransferase activity	0.344664739778274	bayes_pls_golite062009
binding	0.336188540273603	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: