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View Structure Prediction Details

Protein: SPE4
Organism: Saccharomyces cerevisiae
Length: 300 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPE4.

Description E-value Query
Range		 Subject
Range
gi|190406174 - gi|190406174|gb|EDV09441.1| spermine synthase [Saccharomyces cerevisiae RM11-1a]
SPSY_YEAST - Spermine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPE4 PE=1 SV=1
SPE4 - Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pa...
 4.0E-82 [1..300] [1..300]
SPD2_ARATH - Spermidine synthase 2 OS=Arabidopsis thaliana GN=SPDSYN2 PE=1 SV=2
 5.0E-81 [5..299] [42..336]
SPD1_HYONI - Spermidine synthase 1 OS=Hyoscyamus niger PE=2 SV=1
 8.0E-80 [3..299] [13..311]
SPD1_ORYSJ - Spermidine synthase 1 OS=Oryza sativa subsp. japonica GN=SPDSYN1 PE=2 SV=1
SPD1_ORYSA - Spermidine synthase 1 (EC 2.5.1.16) (Putrescine aminopropyltransferase 1) (SPDSY 1) - Oryza sativa (...
 3.0E-79 [8..299] [28..319]
SPD2_DATST - Spermidine synthase 2 OS=Datura stramonium PE=2 SV=1
 7.0E-79 [3..299] [15..313]
SPD2_PEA - Spermidine synthase 2 OS=Pisum sativum GN=SPDSYN2 PE=2 SV=1
 7.0E-79 [8..299] [48..338]
SPDE_COFAR - Spermidine synthase OS=Coffea arabica PE=2 SV=1
 7.0E-79 [8..299] [21..312]

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Predicted Domain #1
Region A:
Residues: [1-65] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNNSQHPYI KDGWFREIND KSFPGQAFTM TVDSILYEAR SEFQDILIFR NKVYGTVLVL  60
   61 DGIVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 504.325697
Match: 1inlA_
Description: Spermidine synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
spermidine synthase activity 2.31131562815571 bayes_pls_golite062009
transferase activity 1.77671966857605 bayes_pls_golite062009
transcription regulator activity 1.61435611638306 bayes_pls_golite062009
DNA binding 1.53375495589674 bayes_pls_golite062009
nucleic acid binding 1.31440474302645 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
binding 0.976078016260105 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 0.837368219068434 bayes_pls_golite062009
N-methyltransferase activity 0.69697643153076 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.644010137949015 bayes_pls_golite062009
methyltransferase activity 0.635463629299812 bayes_pls_golite062009
protein methyltransferase activity 0.57386401278889 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [66-300] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CTEFDEFAYQ EMITHIAMFA HSNPKRVLII GGGDGGVLRE VAKHSCVEDI TMVEIDSSVI  60
   61 ELSRKFLPTL SNGAFDDERL DLKLCDGFKF LQDIGASDVH KKFDVIITDS SDPEGPAEAF 120
  121 FQERYFELLK DALNPNGVVI MQSSENFWLN LKYLHDLKNT AKKVFPNTEY CYTMVPTYTS 180
  181 GQLGLIVCSN NANIPLNIPQ RKISEQEQGK LKYYNPQIHS SAFVLPTWAD KVINE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 504.325697
Match: 1inlA_
Description: Spermidine synthase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle