YRC Public Data Repository - Protein Structure Prediction

Protein:	PUT1
Organism:	Saccharomyces cerevisiae
Length:	476 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUT1.

Description	E-value	Query Range	Subject Range
gi\|172301 - gi\|172301\|gb\|AAA16631.1\| proline oxidase	0.0	[1..476]	[1..476]
gi\|149366203, gi... - gi\|149366203\|ref\|ZP_01888238.1\| multifunctional proline dehydrogenase/delta-1-pyrroline-5-carboxylat... gi\|229897964, gi... - gi\|229897964\|ref\|ZP_04513115.1\| Transcriptional repressor of PutA and PutP /Proline dehydrogenase (P... gi\|108807225, gi... - gi\|108807225\|ref\|YP_651141.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrrolin... gi\|89105425, gi\|... - gi\|89105425\|ref\|ZP_01177944.1\| COG4230: Delta 1-pyrroline-5-carboxylate dehydrogenase [Yersinia pest... gi\|25284839 - pir\|\|AH0225 1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) [imported] - Yersinia pestis (stra... gi\|165926003, gi... - gi\|165926003\|ref\|ZP_02221835.1\| bifunctional PutA protein [Yersinia pestis biovar Orientalis str. F1... gi\|167049507, gi... - gi\|167401118\|ref\|ZP_02306621.1\| bifunctional PutA protein [Yersinia pestis biovar Antiqua str. UG05-... gi\|15979873, gi\|... - gi\|218928970\|ref\|YP_002346845.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrro... gi\|165990138, gi... - gi\|166010794\|ref\|ZP_02231692.1\| bifunctional PutA protein [Yersinia pestis biovar Antiqua str. E1979... gi\|166961838, gi... - gi\|167420143\|ref\|ZP_02311896.1\| bifunctional PutA protein [Yersinia pestis biovar Orientalis str. MG...	0.0	[73..470]	[214..586]
gi\|6693829, gi\|8... - gi\|8132052\|gb\|AAF73193.1\|AF151965_1 proline dehydrogenase [Pseudomonas putida], gi\|6693829\|gb\|AAF250...	0.0	[73..474]	[210..586]
gi\|15026861 - gi\|15026861\|gb\|AAK81670.1\| proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase bifunctional ...	0.0	[73..470]	[158..531]
PUTA_ENTAE - Bifunctional protein PutA OS=Enterobacter aerogenes GN=putA PE=3 SV=1 PUTA_KLEAE - Bifunctional protein putA OS=Klebsiella aerogenes GN=putA PE=3 SV=1	0.0	[49..470]	[189..585]
gi\|25284837 - pir\|\|B85646 proline dehydrogenase, P5C dehydrogenase [imported] - Escherichia coli (strain O157:H7, ... gi\|12514374, gi\|... - gi\|15801003\|ref\|NP_287019.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	0.0	[49..472]	[189..587]
gi\|15830514, gi\|... - gi\|15830514\|ref\|NP_309287.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline... gi\|25284836 - pir\|\|D90786 proline dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509... gi\|15830514, gi\|... - gi\|15830514\|ref\|NP_309287.1\| proline dehydrogenase [Escherichia coli O157:H7], gi\|13360720\|dbj\|BAB34...	0.0	[49..472]	[189..587]
gi\|17430324 - gi\|17430324\|emb\|CAD17089.1\| probable bifunctional: proline dehydrogenase and proline oxidase delta-1... gi\|17548018 - gi\|17548018\|ref\|NP_521420.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	0.0	[73..470]	[219..590]
EG10801 - fused DNA-binding transcriptional regulator /proline dehydrogenase /pyrroline-5-carboxylate dehydrogen... gi\|238861187, gi... - gi\|238900274\|ref\|YP_002926070.1\| fused DNA-binding transcriptional regulator/proline dehydrogenase/p... EG10801 - fused DNA-binding transcriptional regulator /proline dehydrogenase /pyrroline-5-carboxylate dehydrogen... gi\|170080673, gi... - gi\|170080673\|ref\|YP_001729993.1\| multifunctional proline dehydrogenase, delta-1-pyrroline-5-carboxyl... gi\|89107865, gi\|... - gi\|89107865\|ref\|AP_001645.1\| fused DNA-binding transcriptional regulator, proline dehydrogenase, and... PUTA_ECOLI - Bifunctional protein putA [Includes: Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase); Delta-1-...	0.0	[49..472]	[189..587]

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Predicted Domain #1

Region A:
Residues: [1-106]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIASKSSLLV TKSRIPSLCF PLIKRSYVSK TPTHSNTAAN LMVETPAANA NGNSVMAPPN  60
   61 SINFLQTLPK KELFQLGFIG IATLNSFFLN TIIKLFPYIP IPVIKF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-NH group of donors	6.88732579226533	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	5.85999181868044	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	5.85251457886657	bayes_pls_golite062009
oxidoreductase activity	3.26500423104107	bayes_pls_golite062009
catalytic activity	2.15527229494088	bayes_pls_golite062009
methylenetetrahydrofolate reductase (NADPH) activity	1.53575450131902	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [107-476]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVSSLYCGGE NFKEVIECGK RLQKRGISNM MLSLTIENSE GTKSLSSTPV DQIVKETISS  60
   61 VHNILLPNII GQLESKPIND IAPGYIALKP SALVDNPHEV LYNFSNPAYK AQRDQLIENC 120
  121 SKITKEIFEL NQSLLKKYPE RKAPFMVSTI DAEKYDLQEN GVYELQRILF QKFNPTSSKL 180
  181 ISCVGTWQLY LRDSGDHILH ELKLAQENGY KLGLKLVRGA YIHSEKNRNQ IIFGDKTGTD 240
  241 ENYDRIITQV VNDLIINGED SYFGHLVVAS HNYQSQMLVT NLLKSTQDNS YAKSNIVLGQ 300
  301 LLGMADNVTY DLITNHGAKN IIKYVPWGPP LETKDYLLRR LQENGDAVRS DNGWPLIKAI 360
  361 AKSIPKRVGL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	138.79588
Match:	PF01619
Description:	Proline dehydrogenase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: