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View Structure Prediction Details

Protein: FRE6
Organism: Saccharomyces cerevisiae
Length: 712 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE6.

Description E-value Query
Range		 Subject
Range
gi|151941122 - gi|151941122|gb|EDN59500.1| ferric reductase [Saccharomyces cerevisiae YJM789]
FRE6_YEAST - Ferric reductase transmembrane component 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
FRE6 - Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
 0.0 [1..712] [1..712]
gi|68489271, gi|... - gi|68489271|ref|XP_711522.1| likely ferric reductase [Candida albicans SC5314], gi|68489228|ref|XP_7...
gi|238881428 - gi|238881428|gb|EEQ45066.1| conserved hypothetical protein [Candida albicans WO-1]
gi|9963984 - gi|9963984|gb|AAG09788.1|AF254143_1 repressed by TUP1 protein 2; Rbt2p [Candida albicans]
 0.0 [4..712] [6..706]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [172..710] [315..921]
RBOHD_ARATH - Respiratory burst oxidase homolog protein D OS=Arabidopsis thaliana GN=RBOHD PE=1 SV=1
 0.0 [172..710] [315..921]
RBOHB_SOLTU - Respiratory burst oxidase homolog protein B OS=Solanum tuberosum GN=RBOHB PE=1 SV=1
 0.0 [172..710] [260..867]
gi|8131846, gi|8... - gi|8131890|gb|AAF73124.1|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi|8131846...
 0.0 [172..710] [307..938]

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Predicted Domain #1
Region A:
Residues: [1-272] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHRTLLFLTW LISLTKAFNI KLPHTEKKDH LESNAVLACA SYINTLKWSF DSSVVPGFYS  60
   61 TICSYSPAFD TWSLCIFNSL TDQIIPMDNT SFEESLGNVR KTCSFVDKKF SNISLEQYYS 120
  121 SLNNASSHAL EDYGSIESLS TSIRVDRETR SRWIRAFHAH AYNLDISSVY GAYLTYYFVI 180
  181 VGIIAVFFHM SHYNGLNRAL FASRFVNYIR GHFVLPTFLV DKHANHFKFL NVEVFTGLMP 240
  241 NSLEAWIIFG YTLANIIFLS ISYIIDPYNL IF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [273-422] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSHLSQFTRL LADRSGILAF TQFPLIIIFT ARNSFLEFLT GVKFNSFISF HKWIGRIMVL  60
   61 NATIHSLSYS LFAIINHAFK ISNKQLYWKF GIASITVLCV LLVLSLGIVR KRHYEFFLYT 120
  121 HIILALLFFY CCWQHVKIFN GWKEWIVVSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.923 N/A N/A a.24.9 alpha-catenin/vinculin

Predicted Domain #3
Region A:
Residues: [423-540] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIWGLEKLFR IWNILQFRFP KATLINLNTS NNPHDEMFKV IIPKYNRRWH SKPGQYCFIY  60
   61 FLHPLVFWQC HPFTIIDEGE KCVLVIKPKS GLTRFIYNHI LQSLNGKLQL RVAIEGPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.69897
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13408475648113 bayes_pls_golite062009
oxidoreductase activity 0.58197349520772 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
cofactor binding 0.0731141170494622 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [541-712] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPSNLHLDKF DHLLLLSGGT GLPGPLDHAI KLSRNPDKPK SIDLIMAIKN PSFLNGYKSE  60
   61 ILELKNSRSH VNVQVYLTQK TAVTKAANAR DQLIHFDDIM TELTSFAHIG NARPNFSNVI 120
  121 ENAIKSTPPG DSLAVVCCGP PVLVDDVRNT VSQKLLGYPE RIIEYFEEYQ CW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.69897
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle