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View Structure Prediction Details

Protein: PRP16
Organism: Saccharomyces cerevisiae
Length: 1071 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP16.

Description E-value Query
Range
Subject
Range
PRP16 - RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-...
gi|151941625 - gi|151941625|gb|EDN59988.1| Pre-mRNA Processing [Saccharomyces cerevisiae YJM789]
PRP16_YEAST - Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Saccharomyces cerevisiae (strain ATCC 2...
0.0 [1..1071] [1..1071]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..1049] [79..1127]
gi|3024898, gi|3... - gi|3123906|gb|AAC39729.1| pre-mRNA splicing factor [Homo sapiens], sp|Q92620|PR16_HUMAN Pre-mRNA spl...
gi|168274495 - gi|168274495|dbj|BAG09667.1| pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [synthetic co...
0.0 [4..1050] [147..1225]
gi|11358630, gi|... - gi|7630057|emb|CAB88265.1| pre-mRNA splicing factor ATP-dependent RNA helicase-like protein [Arabido...
0.0 [6..1056] [187..1209]
gi|12044832 - gi|12044832|gb|AAG33228.2|AF305070_1 DEAH-box RNA helicase [Chlamydomonas reinhardtii]
0.0 [134..1053] [464..1430]

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Predicted Domain #1
Region A:
Residues: [1-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHSGREERI KDIFKELTSK ELTPGLLLTL QKLAQKPNTN LEQFIASCKA LTKLSSNNPI  60
   61 IFNELLELLK NKSEEDSTGP KKIAPSINKR KKFKIQLDLD DNEDELDSPV QKKPAPTRTL 120
  121 FKRIDKLKAK QLRQYSPTVK DPSPNSEQQT QNGHAETKDY EPTRSEVVEE DREWYDNDDD 180
  181 YGNLVPEPLS ELPEEAKLLP VIRNIDNDDA LRNTVQLYPI PLKQRMEWIP PFLSKFALEN 240
  241 KVPTSIIIGS ISETSSQVSA LSMVNPFRNP DSEFSANAKR GSKLVALRRI NMEHIQQSRD 300
  301 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [301-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTTVLNTAMG EVLGLENNNK AKDKSNQKIC DDTALFTPSK DDIKHTKEQL PVFRCRSQLL  60
   61 SLIRENQVVV IIGETGSGKT TQLAQYLYEE GYANDRGKSI VVTQPRRVAA ISVAKRVAME 120
  121 MQVPLGKEVG YSIRFEDVTD SECTKLKFVT DGILLRETLL DDTLDKYSCV IIDEAHERSL 180
  181 NTDILLGFFK ILLARRRDLK LIITSATMNA KKFSAFFGNA PQFTIPGRTF PVQTIYTSNP 240
  241 VQDYVEAAVS QAVKIHLAND CSSGDILIFM TGQEDIETTF DTLQEKFLQV YSKKFGTANF 300
  301 EEINDIEILP IYSALPADLQ FKIFQDLHGT KRKIIIATNI AETSLTIKGI RYVIDCGYSK 360
  361 LKVYNPKIGL DSLVITPISK ANADQRSGRA GRTAPGTAYR LYTEDTFKED MYLQTIPEIQ 420
  421 RTNLSNTLLL LKSLDVTDEL SKFPFID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1fuuA_
Description: Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [748-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPPLQTFLSS LYELWFIGAI DTSGQLTPLG LQMAKFPLQP SLSKILLIAV RNGCSDEMLT  60
   61 IVSMLSVPQV FYR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.797 a.39.1 EF-hand
View Download 0.761 a.74.1 Cyclin-like
View Download 0.868 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.649 a.28.2 Colicin E immunity proteins
View Download 0.619 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.587 a.4.5 "Winged helix" DNA-binding domain
View Download 0.530 a.4.1 Homeodomain-like
View Download 0.505 d.216.1 Rotavirus NSP2 fragment, N-terminal domain
View Download 0.503 a.4.5 "Winged helix" DNA-binding domain
View Download 0.492 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.477 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.477 a.144.1 PABC (PABP) domain
View Download 0.474 a.4.1 Homeodomain-like
View Download 0.451 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.447 a.5.6 Hypothetical protein MTH1615
View Download 0.441 a.39.1 EF-hand
View Download 0.434 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.423 a.4.5 "Winged helix" DNA-binding domain
View Download 0.387 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.381 a.65.1 Annexin
View Download 0.374 a.39.1 EF-hand
View Download 0.365 a.4.1 Homeodomain-like
View Download 0.348 a.77.1 DEATH domain
View Download 0.348 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.345 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.345 a.64.2 Bacteriocin AS-48
View Download 0.335 a.39.1 EF-hand
View Download 0.320 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.314 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.313 a.21.1 HMG-box
View Download 0.312 a.24.17 Group V grass pollen allergen
View Download 0.302 a.64.1 Saposin
View Download 0.290 a.21.1 HMG-box
View Download 0.280 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.261 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.249 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.249 a.159.2 FF domain
View Download 0.249 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.239 a.24.15 FAD-dependent thiol oxidase
View Download 0.229 d.66.1 Alpha-L RNA-binding motif
View Download 0.222 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.218 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.206 a.59.1 PAH2 domain
View Download 0.206 a.60.8 HRDC-like
View Download 0.201 d.52.5 Probable GTPase Der, C-terminal domain

Predicted Domain #4
Region A:
Residues: [821-1071]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKERQKEADI ARNKFFIAKS DHLTLLNVFE QWRANNFSSH WCNKHFVQYK SLVRARDIRD  60
   61 QLLTILKSQK IPVISSGKDW DIIKKCICSG FAHQAAKITG LRNYVHLKTG VSVQLHPTSA 120
  121 LHGLGDLPPY VVYHELLMTS KEYICCVTSV DPFWLMEYGG LLYDIKRIKN DQEATTTGLF 180
  181 GEHYEHTLDK VEDDIDINIR RCKDMRDSVI QELKMTDNSN KEDKKQKTKK QNILNGKENS 240
  241 MKPFKRRKPF F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [899-1071]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWDIIKKCIC SGFAHQAAKI TGLRNYVHLK TGVSVQLHPT SALHGLGDLP PYVVYHELLM  60
   61 TSKEYICCVT SVDPFWLMEY GGLLYDIKRI KNDQEATTTG LFGEHYEHTL DKVEDDIDIN 120
  121 IRRCKDMRDS VIQELKMTDN SNKEDKKQKT KKQNILNGKE NSMKPFKRRK PFF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle