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View Structure Prediction Details

Protein: PRP16
Organism: Saccharomyces cerevisiae
Length: 1071 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP16.

Description E-value Query
Range
Subject
Range
PRP16 - RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-...
gi|151941625 - gi|151941625|gb|EDN59988.1| Pre-mRNA Processing [Saccharomyces cerevisiae YJM789]
PRP16_YEAST - Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Saccharomyces cerevisiae (strain ATCC 2...
0.0 [1..1071] [1..1071]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..1049] [79..1127]
gi|3024898, gi|3... - gi|3123906|gb|AAC39729.1| pre-mRNA splicing factor [Homo sapiens], sp|Q92620|PR16_HUMAN Pre-mRNA spl...
gi|168274495 - gi|168274495|dbj|BAG09667.1| pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [synthetic co...
0.0 [4..1050] [147..1225]
gi|11358630, gi|... - gi|7630057|emb|CAB88265.1| pre-mRNA splicing factor ATP-dependent RNA helicase-like protein [Arabido...
0.0 [6..1056] [187..1209]
gi|12044832 - gi|12044832|gb|AAG33228.2|AF305070_1 DEAH-box RNA helicase [Chlamydomonas reinhardtii]
0.0 [134..1053] [464..1430]

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Predicted Domain #1
Region A:
Residues: [1-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHSGREERI KDIFKELTSK ELTPGLLLTL QKLAQKPNTN LEQFIASCKA LTKLSSNNPI  60
   61 IFNELLELLK NKSEEDSTGP KKIAPSINKR KKFKIQLDLD DNEDELDSPV QKKPAPTRTL 120
  121 FKRIDKLKAK QLRQYSPTVK DPSPNSEQQT QNGHAETKDY EPTRSEVVEE DREWYDNDDD 180
  181 YGNLVPEPLS ELPEEAKLLP VIRNIDNDDA LRNTVQLYPI PLKQRMEWIP PFLSKFALEN 240
  241 KVPTSIIIGS ISETSSQVSA LSMVNPFRNP DSEFSANAKR GSKLVALRRI NMEHIQQSRD 300
  301 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [301-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTTVLNTAMG EVLGLENNNK AKDKSNQKIC DDTALFTPSK DDIKHTKEQL PVFRCRSQLL  60
   61 SLIRENQVVV IIGETGSGKT TQLAQYLYEE GYANDRGKSI VVTQPRRVAA ISVAKRVAME 120
  121 MQVPLGKEVG YSIRFEDVTD SECTKLKFVT DGILLRETLL DDTLDKYSCV IIDEAHERSL 180
  181 NTDILLGFFK ILLARRRDLK LIITSATMNA KKFSAFFGNA PQFTIPGRTF PVQTIYTSNP 240
  241 VQDYVEAAVS QAVKIHLAND CSSGDILIFM TGQEDIETTF DTLQEKFLQV YSKKFGTANF 300
  301 EEINDIEILP IYSALPADLQ FKIFQDLHGT KRKIIIATNI AETSLTIKGI RYVIDCGYSK 360
  361 LKVYNPKIGL DSLVITPISK ANADQRSGRA GRTAPGTAYR LYTEDTFKED MYLQTIPEIQ 420
  421 RTNLSNTLLL LKSLDVTDEL SKFPFID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1fuuA_
Description: Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [748-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPPLQTFLSS LYELWFIGAI DTSGQLTPLG LQMAKFPLQP SLSKILLIAV RNGCSDEMLT  60
   61 IVSMLSVPQV FYR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.868 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain

Predicted Domain #4
Region A:
Residues: [821-1071]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKERQKEADI ARNKFFIAKS DHLTLLNVFE QWRANNFSSH WCNKHFVQYK SLVRARDIRD  60
   61 QLLTILKSQK IPVISSGKDW DIIKKCICSG FAHQAAKITG LRNYVHLKTG VSVQLHPTSA 120
  121 LHGLGDLPPY VVYHELLMTS KEYICCVTSV DPFWLMEYGG LLYDIKRIKN DQEATTTGLF 180
  181 GEHYEHTLDK VEDDIDINIR RCKDMRDSVI QELKMTDNSN KEDKKQKTKK QNILNGKENS 240
  241 MKPFKRRKPF F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [899-1071]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWDIIKKCIC SGFAHQAAKI TGLRNYVHLK TGVSVQLHPT SALHGLGDLP PYVVYHELLM  60
   61 TSKEYICCVT SVDPFWLMEY GGLLYDIKRI KNDQEATTTG LFGEHYEHTL DKVEDDIDIN 120
  121 IRRCKDMRDS VIQELKMTDN SNKEDKKQKT KKQNILNGKE NSMKPFKRRK PFF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle