| Protein: | FOX2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 900 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOX2.
| Description | E-value | Query Range |
Subject Range |
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0.0 | [1..900] | [1..900] |
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0.0 | [1..900] | [1..901] |
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0.0 | [2..900] | [1..906] |
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0.0 | [1..893] | [1..893] |
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0.0 | [1..899] | [1..874] |
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0.0 | [314..897] | [1..609] |
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0.0 | [314..900] | [1..613] |
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0.0 | [314..897] | [1..608] |
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0.0 | [314..897] | [1..608] |
|
Region A: Residues: [1-258] |
1 11 21 31 41 51
| | | | | |
1 MPGNLSFKDR VVVITGAGGG LGKVYALAYA SRGAKVVVND LGGTLGGSGH NSKAADLVVD 60
61 EIKKAGGIAV ANYDSVNENG EKIIETAIKE FGRVDVLINN AGILRDVSFA KMTEREFASV 120
121 VDVHLTGGYK LSRAAWPYMR SQKFGRIINT ASPAGLFGNF GQANYSAAKM GLVGLAETLA 180
181 KEGAKYNINV NSIAPLARSR MTENVLPPHI LKQLGPEKIV PLVLYLTHES TKVSNSIFEL 240
241 AAGFFGQLRW ERSSGQIF
|
| Detection Method: |  |
| Confidence: | 17.221849 |
| Match: | 1cwuA_ |
| Description: | Enoyl-ACP reductase |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [259-314] |
1 11 21 31 41 51
| | | | | |
1 NPDPKTYTPE AILNKWKEIT DYRDKPFNKT QHPYQLSDYN DLITKAKKLP PNEQGS
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.564 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.639 | d.68.3 | SirA-like |
| View | Download | 0.641 | a.139.1 | Type I dockerin domain |
| View | Download | 0.418 | d.11.1 | Penicillin-binding protein 2x (pbp-2x), c-terminal domain |
| View | Download | 0.343 | a.4.10 | N-terminal Zn binding domain of HIV integrase |
| View | Download | 0.335 | a.157.1 | Skp1 dimerisation domain-like |
| View | Download | 0.326 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.311 | a.4.1 | Homeodomain-like |
| View | Download | 0.306 | a.4.1 | Homeodomain-like |
| View | Download | 0.305 | a.4.1 | Homeodomain-like |
| View | Download | 0.302 | a.4.1 | Homeodomain-like |
| View | Download | 0.298 | a.2.7 | tRNA-binding arm |
| View | Download | 0.295 | a.108.1 | Ribosomal protein L7/12, oligomerisation (N-terminal) domain |
| View | Download | 0.287 | a.17.1 | p8-MTCP1 |
| View | Download | 0.284 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.276 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.267 | d.68.3 | SirA-like |
| View | Download | 0.266 | a.4.1 | Homeodomain-like |
| View | Download | 0.261 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.257 | a.179.1 | Replisome organizer (g39p helicase loader/inhibitor protein) |
| View | Download | 0.254 | a.157.1 | Skp1 dimerisation domain-like |
| View | Download | 0.254 | a.4.1 | Homeodomain-like |
| View | Download | 0.243 | d.11.1 | Penicillin-binding protein 2x (pbp-2x), c-terminal domain |
| View | Download | 0.237 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.227 | a.4.1 | Homeodomain-like |
| View | Download | 0.226 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.223 | d.37.1 | CBS-domain |
| View | Download | 0.219 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.215 | a.4.1 | Homeodomain-like |
| View | Download | 0.208 | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.207 | c.78.2 | Aspartate/glutamate racemase |
| View | Download | 0.205 | d.68.3 | SirA-like |
| View | Download | 0.203 | a.4.1 | Homeodomain-like |
| View | Download | 0.203 | a.60.3 | C-terminal domain of RNA polymerase alpha subunit |
| View | Download | 0.201 | a.140.2 | SAP domain |
| Term | Confidence | Notes |
| CoA hydrolase activity | 2.8126606339235 | bayes_pls_golite062009 |
| acyl-CoA thioesterase activity | 2.60197973503923 | bayes_pls_golite062009 |
| thiolester hydrolase activity | 1.58440062118102 | bayes_pls_golite062009 |
| 3-hydroxyacyl-CoA dehydrogenase activity | 1.14159464719086 | bayes_pls_golite062009 |
| catalytic activity | 0.74605540351792 | bayes_pls_golite062009 |
| binding | 0.713964827833761 | bayes_pls_golite062009 |
| hydrolase activity | 0.679321026490004 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 0.616975153284172 | bayes_pls_golite062009 |
|
Region A: Residues: [315-596] |
1 11 21 31 41 51
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1 VKIKSLCNKV VVVTGAGGGL GKSHAIWFAR YGAKVVVNDI KDPFSVVEEI NKLYGEGTAI 60
61 PDSHDVVTEA PLIIQTAISK FQRVDILVNN AGILRDKSFL KMKDEEWFAV LKVHLFSTFS 120
121 LSKAVWPIFT KQKSGFIINT TSTSGIYGNF GQANYAAAKA AILGFSKTIA LEGAKRGIIV 180
181 NVIAPHAETA MTKTIFSEKE LSNHFDASQV SPLVVLLASE ELQKYSGRRV IGQLFEVGGG 240
241 WCGQTRWQRS SGYVSIKETI EPEEIKENWN HITDFSRNTI NP
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| Detection Method: | |
| Confidence: | 417.228787 |
| Match: | 1edoA_ |
| Description: | beta-keto acyl carrier protein reductase |
Matching Structure (courtesy of the PDB): |
|
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Region A: Residues: [597-699] |
1 11 21 31 41 51
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1 SSTEESSMAT LQAVQKAHSS KELDDGLFKY TTKDCILYNL GLGCTSKELK YTYENDPDFQ 60
61 VLPTFAVIPF MQATATLAMD NLVDNFNYAM LLHGEQYFKL CTP
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| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.221 | 0.024 | enoyl-CoA hydratase activity | d.95.2 | Homing endonucleases |
| View | Download | 0.210 | 0.017 | enoyl-CoA hydratase activity | b.34.9 | Tudor/PWWP/MBT |
|
Region A: Residues: [700-757] |
1 11 21 31 41 51
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1 TMPSNGTLKT LAKPLQVLDK NGKAALVVGG FETYDIKTKK LIAYNEGSFF IRGAHVPP
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.483 | d.58.17 | Metal-binding domain |
| View | Download | 0.415 | d.186.1 | Head-to-tail joining protein W, gpW |
| View | Download | 0.411 | d.76.1 | GYF domain |
| View | Download | 0.527 | d.58.23 | Probable ACP-binding domain of malonyl-CoA ACP transacylase |
| View | Download | 0.442 | d.58.23 | Probable ACP-binding domain of malonyl-CoA ACP transacylase |
| View | Download | 0.411 | d.186.1 | Head-to-tail joining protein W, gpW |
| View | Download | 0.411 | d.186.1 | Head-to-tail joining protein W, gpW |
| View | Download | 0.383 | d.58.17 | Metal-binding domain |
| View | Download | 0.381 | d.186.1 | Head-to-tail joining protein W, gpW |
| View | Download | 0.379 | d.186.1 | Head-to-tail joining protein W, gpW |
| View | Download | 0.359 | d.58.17 | Metal-binding domain |
| View | Download | 0.342 | d.93.1 | SH2 domain |
| View | Download | 0.321 | d.58.24 | CheY-binding domain of CheA |
| View | Download | 0.316 | d.93.1 | SH2 domain |
| View | Download | 0.282 | d.50.1 | dsRNA-binding domain-like |
| View | Download | 0.274 | d.58.3 | Protease propeptides/inhibitors |
| View | Download | 0.259 | d.93.1 | SH2 domain |
| View | Download | 0.253 | d.58.49 | YajQ-like |
| View | Download | 0.247 | d.37.1 | CBS-domain |
| View | Download | 0.247 | d.58.17 | Metal-binding domain |
| View | Download | 0.231 | b.61.3 | D-aminopeptidase, middle and C-terminal domains |
| View | Download | 0.230 | g.18.1 | Complement control module/SCR domain |
| View | Download | 0.217 | d.58.24 | CheY-binding domain of CheA |
| View | Download | 0.209 | d.50.1 | dsRNA-binding domain-like |
| View | Download | 0.204 | b.122.1 | PUA domain-like |
| View | Download | 0.202 | g.37.1 | C2H2 and C2HC zinc fingers |
| View | Download | 0.201 | b.71.1 | Glycosyl hydrolase domain |
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Region A: Residues: [758-900] |
1 11 21 31 41 51
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1 EKEVRDGKRA KFAVQNFEVP HGKVPDFEAE ISTNKDQAAL YRLSGDFNPL HIDPTLAKAV 60
61 KFPTPILHGL CTLGISAKAL FEHYGPYEEL KVRFTNVVFP GDTLKVKAWK QGSVVVFQTI 120
121 DTTRNVIVLD NAAVKLSQAK SKL
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.521 | 0.268 | enoyl-CoA hydratase activity | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.550 | 0.054 | enoyl-CoA hydratase activity | a.96.1 | DNA-glycosylase |
| View | Download | 0.509 | 0.035 | enoyl-CoA hydratase activity | d.227.1 | OsmC-like |
| View | Download | 0.519 | N/A | N/A | d.79.2 | Tubulin/Dihydroxyacetone kinase C-terminal domain |
| View | Download | 0.479 | N/A | N/A | c.37.1 | P-loop containing nucleoside triphosphate hydrolases |
| View | Download | 0.466 | N/A | N/A | b.18.1 | Galactose-binding domain-like |
| View | Download | 0.465 | N/A | N/A | d.38.1 | Thioesterase/thiol ester dehydrase-isomerase |
| View | Download | 0.445 | N/A | N/A | f.1.5 | Exotoxin A, middle domain |
| View | Download | 0.430 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.417 | N/A | N/A | d.131.1 | DNA clamp |
| View | Download | 0.407 | N/A | N/A | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.402 | N/A | N/A | d.17.4 | NTF2-like |
| View | Download | 0.381 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.379 | N/A | N/A | b.60.1 | Lipocalins |
| View | Download | 0.362 | N/A | N/A | d.131.1 | DNA clamp |
| View | Download | 0.357 | N/A | N/A | d.134.1 | Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 |
| View | Download | 0.356 | N/A | N/A | a.73.1 | Retrovirus capsid protein, N-terminal core domain |
| View | Download | 0.343 | N/A | N/A | d.41.5 | Molybdopterin synthase subunit MoaE |
| View | Download | 0.341 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.340 | N/A | N/A | d.123.1 | Sporulation responce regulatory protein Spo0B |
| View | Download | 0.333 | N/A | N/A | c.49.1 | Pyruvate kinase, C-terminal domain |
| View | Download | 0.328 | N/A | N/A | d.58.41 | SEA domain |
| View | Download | 0.309 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.287 | N/A | N/A | a.167.1 | Porin chaperone SurA, peptide-binding domain |
| View | Download | 0.286 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.281 | N/A | N/A | d.110.3 | PYP-like sensor domain (PAS domain) |
| View | Download | 0.280 | N/A | N/A | d.17.1 | Cystatin/monellin |
| View | Download | 0.275 | N/A | N/A | d.58.46 | eEF1-gamma domain |
| View | Download | 0.268 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.267 | N/A | N/A | d.110.1 | Profilin (actin-binding protein) |
| View | Download | 0.267 | N/A | N/A | d.13.1 | HIT-like |
| View | Download | 0.264 | N/A | N/A | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.262 | N/A | N/A | c.3.1 | FAD/NAD(P)-binding domain |
| View | Download | 0.257 | N/A | N/A | d.110.3 | PYP-like sensor domain (PAS domain) |
| View | Download | 0.252 | N/A | N/A | c.51.1 | Anticodon-binding domain of Class II aaRS |
| View | Download | 0.246 | N/A | N/A | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.238 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.238 | N/A | N/A | d.21.1 | Diaminopimelate epimerase-like |
| View | Download | 0.237 | N/A | N/A | c.47.2 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
| View | Download | 0.236 | N/A | N/A | d.143.1 | SAICAR synthase-like |
| View | Download | 0.231 | N/A | N/A | b.125.1 | Lipoprotein localization factors LolAB |
| View | Download | 0.231 | N/A | N/A | d.38.1 | Thioesterase/thiol ester dehydrase-isomerase |
| View | Download | 0.228 | N/A | N/A | d.38.1 | Thioesterase/thiol ester dehydrase-isomerase |
| View | Download | 0.228 | N/A | N/A | c.51.1 | Anticodon-binding domain of Class II aaRS |
| View | Download | 0.226 | N/A | N/A | d.52.3 | Prokaryotic type KH domain (KH-domain type II) |
| View | Download | 0.219 | N/A | N/A | d.2.1 | Lysozyme-like |
| View | Download | 0.213 | N/A | N/A | d.105.1 | Clathrin adaptor appendage, alpha and beta chain-specific domain |
| View | Download | 0.213 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.212 | N/A | N/A | d.107.1 | Ran-binding protein mog1p |
| View | Download | 0.209 | N/A | N/A | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.205 | N/A | N/A | c.57.1 | Molybdenum cofactor biosynthesis proteins |
| View | Download | 0.203 | N/A | N/A | d.95.2 | Homing endonucleases |
