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View Structure Prediction Details

Protein: FRE2
Organism: Saccharomyces cerevisiae
Length: 711 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE2.

Description E-value Query
Range
Subject
Range
FRE2_YEAST - Ferric/cupric reductase transmembrane component 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
FRE2 - Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u...
0.0 [1..711] [1..711]
gi|8131846, gi|8... - gi|8131890|gb|AAF73124.1|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi|8131846...
0.0 [72..709] [199..938]
RBOHD_ARATH - Respiratory burst oxidase homolog protein D OS=Arabidopsis thaliana GN=RBOHD PE=1 SV=1
0.0 [72..709] [207..921]
gi|17384016 - gi|17384016|emb|CAC87256.1| NADPH oxidase [Nicotiana tabacum]
0.0 [71..709] [229..962]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [72..709] [207..921]

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Predicted Domain #1
Region A:
Residues: [1-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHWTSILSAI LLFCLSGARA SPAKTVIRNK VPLLVTNACT RIFQKVTWEY TSKSKRSSPV  60
   61 CSYEPAFQSM LYCIYETLDE KGYSNKTLEK TFSTIKKNCA SYSDALQNMT NSEFYDVLNN 120
  121 GTRHMTPYVK GSANLTYPVE MDTQLRKAYY HALHGFYANL DVGNIYGGII CAYFVAIMAF 180
  181 AGVLHCMNYT PFKTVLLKQK LVGYVRGYLT LPTIGSKH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [219-344]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASDFSYFRIF TGYLPTRLEG IIILGYLVLH TVFLAYGYEY DPENIIFKSR RVQVARYVAD  60
   61 RSGVLAFAHF PLIVLFAGRN NFLEYISGVK YTSFIMFHKW LGRMMFLDAM IHGSAYTSYT 120
  121 VANKTW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [345-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATSKNRLYWQ FGVAALCLAG TMVFFSFAVF RKYFYEAFLF LHIVLGAMFF YACWEHVVSL  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.465 a.4.1 Homeodomain-like
View Download 0.727 a.65.1 Annexin
View Download 0.480 a.16.1 S15/NS1 RNA-binding domain
View Download 0.469 f.13.1 Family A G protein-coupled receptor-like
View Download 0.523 a.118.11 Cytochrome c oxidase subunit E
View Download 0.916 a.24.9 alpha-catenin/vinculin
View Download 0.869 a.7.1 Spectrin repeat
View Download 0.853 a.19.1 Fertilization protein
View Download 0.833 a.47.2 t-snare proteins
View Download 0.832 a.24.14 FAT domain of focal adhesion kinase
View Download 0.402 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.401 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.400 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.379 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.360 a.64.2 Bacteriocin AS-48
View Download 0.349 a.118.8 TPR-like
View Download 0.331 a.4.5 "Winged helix" DNA-binding domain
View Download 0.328 a.4.1 Homeodomain-like
View Download 0.313 a.7.6 Ribosomal protein S20
View Download 0.313 a.4.5 "Winged helix" DNA-binding domain
View Download 0.295 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.293 a.112.1 Description not found.
View Download 0.290 a.4.1 Homeodomain-like
View Download 0.282 a.2.7 tRNA-binding arm
View Download 0.279 b.84.2 Rudiment single hybrid motif
View Download 0.277 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.271 a.17.1 p8-MTCP1
View Download 0.270 a.4.1 Homeodomain-like
View Download 0.266 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.264 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.264 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.263 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.252 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.249 a.64.1 Saposin
View Download 0.249 a.101.1 Uteroglobin-like
View Download 0.246 a.4.1 Homeodomain-like
View Download 0.246 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.245 g.59.1 Zinc-binding domain of translation initiation factor 2 beta
View Download 0.244 a.112.1 Description not found.
View Download 0.242 a.157.1 Skp1 dimerisation domain-like
View Download 0.233 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.232 f.15.1 Small-conductance potassium channel
View Download 0.230 a.4.5 "Winged helix" DNA-binding domain
View Download 0.225 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.219 a.126.1 Serum albumin-like
View Download 0.214 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.214 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.213 a.4.1 Homeodomain-like
View Download 0.213 a.4.1 Homeodomain-like
View Download 0.211 a.4.1 Homeodomain-like
View Download 0.209 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.204 a.85.1 Hemocyanin, N-terminal domain
View Download 0.203 a.16.1 S15/NS1 RNA-binding domain
View Download 0.203 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.201 a.60.2 RuvA domain 2-like

Predicted Domain #4
Region A:
Residues: [406-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIEWIYTAIA IWIVDRIIRI IKASYFGFPK ASLQLIGDDL IRLTVKKPAR PWRAKPGQYV  60
   61 FVSFLHPLYF WQSHPFTVLD SVSKNGELVI ILKEKKGVTR LVKKYVCRNG GKTSMRLAIE 120
  121 GPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.45374095556065 bayes_pls_golite062009
transferase activity 1.15480450573972 bayes_pls_golite062009
binding 1.13408475648113 bayes_pls_golite062009
oxidoreductase activity 0.27336340260908 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
cofactor binding 0.0731141170494622 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [529-711]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSPVNNYN NVLLLTGGTG LPGPIAHAIK LGKTSAAAGK QSVKLVIAVR GFDVLEAYKP  60
   61 ELMCLENLNV QLHIYNTMEV PSLTPSDSLD ISQQDEKADE KGTVVATTLE KSANPLGFDG 120
  121 VVFHCGRPNV KELLHEAAEL SGSLSVVCCG PPIFVDKVRN ETAKIVLDKS AKAIEYFEEY 180
  181 QCW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle