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View Structure Prediction Details

Protein: FRE2
Organism: Saccharomyces cerevisiae
Length: 711 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE2.

Description E-value Query
Range
Subject
Range
FRE2_YEAST - Ferric/cupric reductase transmembrane component 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
FRE2 - Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u...
0.0 [1..711] [1..711]
gi|8131846, gi|8... - gi|8131890|gb|AAF73124.1|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi|8131846...
0.0 [72..709] [199..938]
RBOHD_ARATH - Respiratory burst oxidase homolog protein D OS=Arabidopsis thaliana GN=RBOHD PE=1 SV=1
0.0 [72..709] [207..921]
gi|17384016 - gi|17384016|emb|CAC87256.1| NADPH oxidase [Nicotiana tabacum]
0.0 [71..709] [229..962]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [72..709] [207..921]

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Predicted Domain #1
Region A:
Residues: [1-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHWTSILSAI LLFCLSGARA SPAKTVIRNK VPLLVTNACT RIFQKVTWEY TSKSKRSSPV  60
   61 CSYEPAFQSM LYCIYETLDE KGYSNKTLEK TFSTIKKNCA SYSDALQNMT NSEFYDVLNN 120
  121 GTRHMTPYVK GSANLTYPVE MDTQLRKAYY HALHGFYANL DVGNIYGGII CAYFVAIMAF 180
  181 AGVLHCMNYT PFKTVLLKQK LVGYVRGYLT LPTIGSKH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [219-344]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASDFSYFRIF TGYLPTRLEG IIILGYLVLH TVFLAYGYEY DPENIIFKSR RVQVARYVAD  60
   61 RSGVLAFAHF PLIVLFAGRN NFLEYISGVK YTSFIMFHKW LGRMMFLDAM IHGSAYTSYT 120
  121 VANKTW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [345-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATSKNRLYWQ FGVAALCLAG TMVFFSFAVF RKYFYEAFLF LHIVLGAMFF YACWEHVVSL  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.916 a.24.9 alpha-catenin/vinculin

Predicted Domain #4
Region A:
Residues: [406-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIEWIYTAIA IWIVDRIIRI IKASYFGFPK ASLQLIGDDL IRLTVKKPAR PWRAKPGQYV  60
   61 FVSFLHPLYF WQSHPFTVLD SVSKNGELVI ILKEKKGVTR LVKKYVCRNG GKTSMRLAIE 120
  121 GPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.45374095556065 bayes_pls_golite062009
transferase activity 1.15480450573972 bayes_pls_golite062009
binding 1.13408475648113 bayes_pls_golite062009
oxidoreductase activity 0.27336340260908 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
cofactor binding 0.0731141170494622 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [529-711]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSPVNNYN NVLLLTGGTG LPGPIAHAIK LGKTSAAAGK QSVKLVIAVR GFDVLEAYKP  60
   61 ELMCLENLNV QLHIYNTMEV PSLTPSDSLD ISQQDEKADE KGTVVATTLE KSANPLGFDG 120
  121 VVFHCGRPNV KELLHEAAEL SGSLSVVCCG PPIFVDKVRN ETAKIVLDKS AKAIEYFEEY 180
  181 QCW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle