YRC Public Data Repository - Protein Structure Prediction

Protein:	OXP1
Organism:	Saccharomyces cerevisiae
Length:	1286 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OXP1.

Description	E-value	Query Range	Subject Range
gi\|16331930, gi\|... - gi\|16331930\|ref\|NP_442658.1\| hypothetical protein slr0697 [Synechocystis sp. PCC 6803], gi\|1006579\|d... gi\|7429908 - pir\|\|S77037 hypothetical protein slr0697 - Synechocystis sp. (strain PCC 6803)	0.0	[7..1282]	[3..1249]
YAOF_SCHPO - Uncharacterized protein C11D3.15 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC11D3.... SPAC11D3.15 - oxoprolinase	0.0	[4..1275]	[1..1276]
gi\|19572990 - gi\|19572990\|emb\|CAD28130.1\| putative 5-oxoprolinase [Anopheles gambiae] gi\|118794464, gi... - ref\|XP_321495.1\| ENSANGP00000025339 [Anopheles gambiae], gi\|118794464\|ref\|XP_321495.3\| AGAP001606-P...	0.0	[1..1286]	[1..1295]
gi\|25305514 - pir\|\|B95845 conserved hypothetical protein [imported] - Sinorhizobium meliloti (strain 1021) magapla... gi\|16263774, gi\|... - gi\|16263774\|ref\|NP_436566.1\| hypothetical protein SM_b20023 [Sinorhizobium meliloti 1021], gi\|151398...	0.0	[10..1283]	[11..1203]
gi\|14022305, gi\|... - gi\|14022305\|dbj\|BAB48915.1\| 5-oxoprolinase [Mesorhizobium loti MAFF303099], gi\|13471563\|ref\|NP_10312...	0.0	[2..1283]	[1..1209]
OPLA_ARATH - 5-oxoprolinase OS=Arabidopsis thaliana GN=OXP1 PE=2 SV=1	0.0	[3..1282]	[6..1263]
gi\|7429907 - pir\|\|E70627 hypothetical protein Rv0266c - Mycobacterium tuberculosis (strain H37RV) gi\|197738238, gi... - gi\|254366710\|ref\|ZP_04982754.1\| 5-oxoprolinase oplA [Mycobacterium tuberculosis str. Haarlem], gi\|19... gi\|148504183, gi... - gi\|148660031\|ref\|YP_001281554.1\| putative 5-oxoprolinase OplA [Mycobacterium tuberculosis H37Ra], gi... gi\|121491826, gi... - gi\|121636179\|ref\|YP_976402.1\| putative 5-oxoprolinase oplA [Mycobacterium bovis BCG str. Pasteur 117... gi\|215409755 - gi\|215409755\|ref\|ZP_03418563.1\| 5-oxoprolinase oplA [Mycobacterium tuberculosis 94_M4241A] gi\|215406264 - gi\|215406264\|ref\|ZP_03418445.1\| 5-oxoprolinase oplA [Mycobacterium tuberculosis 02_1987] gi\|31791444, gi\|... - gi\|31791444\|ref\|NP_853937.1\| 5-oxoprolinase [Mycobacterium bovis AF2122/97], gi\|31617029\|emb\|CAD9313... gi\|219556072 - gi\|219556072\|ref\|ZP_03535148.1\| 5-oxoprolinase oplA [Mycobacterium tuberculosis T17] gi\|1850111, gi\|1... - gi\|1850111\|emb\|CAB06678.1\| PROBABLE 5-OXOPROLINASE OPLA (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE... gi\|218756006 - gi\|218756006\|ref\|ZP_03534802.1\| 5-oxoprolinase oplA [Mycobacterium tuberculosis GM 1503] gi\|148719988, gi... - gi\|76785997\|ref\|ZP_00773159.1\| COG0145: N-methylhydantoinase A/acetone carboxylase, beta subunit [My... gi\|124603436, gi... - gi\|81252316\|ref\|ZP_00876910.1\| COG0145: N-methylhydantoinase A/acetone carboxylase, beta subunit [My... gi\|224771765, gi... - gi\|224988652\|ref\|YP_002643339.1\| putative 5-oxoprolinase [Mycobacterium bovis BCG str. Tokyo 172], g... gi\|253797191, gi... - gi\|253797191\|ref\|YP_003030192.1\| 5-oxoprolinase oplA [Mycobacterium tuberculosis KZN 1435], gi\|25331... gi\|254817568 - gi\|254817568\|ref\|ZP_05222569.1\| putative 5-oxoprolinase [Mycobacterium tuberculosis KZN 4207]	0.0	[1..1283]	[1..1200]
gi\|25305509 - pir\|\|H87542 hydantoinase/oxoprolinase [imported] - Caulobacter crescentus gi\|16126608, gi\|... - gi\|16126608\|ref\|NP_421172.1\| hydantoinase/oxoprolinase [Caulobacter crescentus CB15], gi\|13423900\|gb...	0.0	[1..1283]	[5..1195]
OXP1 - 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green... OPLA_YEAST - 5-oxoprolinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OXP1 PE=1 SV=2	0.0	[1..1286]	[1..1286]
OPLA_RAT - (P97608) 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5-OPase)	0.0	[3..1286]	[5..1258]

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Predicted Domain #1

Region A:
Residues: [1-664]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKGNIRIAI DKGGTFTDCV GNIGTGKQEH DTVIKLLSVD PKNYPDAPLE GIRRLLEVLE  60
   61 HKTIPRGIPL DISNVRSLRM GTTLATNCAL ERNGERCAFI TTKGFKDSLL IGDQTRPDIF 120
  121 NLNIKKVVPL YDTVVEIDER VTLEDFSEDP YFTKSSPNEQ EGILEGNSGE MVRVIKKPDE 180
  181 SSVRSILKVL YASGIKSIAI AFLHSYTFPD HERIVGNIAR EIGFSHVSLS SEVSPMIKFL 240
  241 PRAHSSVADA YLTPVIKKYL NSISAGLSHA EDTHIQFMQS DGGLVDGGKF SGLKSILSGP 300
  301 AGGVIGYSST CYDKNNNIPL IGFDMGGTST DVSRYGDGRL EHVFETVTAG IIIQSPQLDI 360
  361 HTVAAGGSSI LSWKNGLFRV GPDSAAADPG PAAYRKGGPL TITDANLFLG RLVPEFFPKI 420
  421 FGPNEDESLD LETTTLKFRE LTDVINKDLN SNLTMEEVAY GFIKVANECM ARPVRAITEA 480
  481 KGHVVSQHRL VSFGGAGGQH AIAVADSLGI DTVLIHRYSS ILSAYGIFLA DVIEENQEPC 540
  541 SFILGEPETI LKVKKRFLEL SKNSIKNLLS QSFSREDIVL ERYLNLRYEG TETSLMILQK 600
  601 YDDQWNFREW FSEAHKKEFG FSFDDKRIII DDIRIRAIGK SGVRKEKTVD EQLIEISHFK 660
  661 KADV

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	1000.0
Match:	PF01968
Description:	Hydantoinase/oxoprolinase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
carbohydrate kinase activity	1.59015355865021	bayes_pls_golite062009
kinase activity	0.936112985314189	bayes_pls_golite062009
binding	0.874703945174078	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.839311348589465	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.644753323874683	bayes_pls_golite062009
hexokinase activity	0.570508441475985	bayes_pls_golite062009
hydrolase activity	0.440062766964367	bayes_pls_golite062009
catalytic activity	0.308539563780047	bayes_pls_golite062009
transferase activity	0.0223144423385645	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [665-741]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDASFTQKA YFDNKWVDTA VFKIDDLPAG TIIEGPAILA DGTQTNIILP NSQATILNSH  60
   61 IFIKINQKAA KTLSKSG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.729	0.000	cytoplasm	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.894	0.000	cytoplasm	b.71.1	Glycosyl hydrolase domain
View	Download	0.671	0.000	cytoplasm	d.15.7	Immunoglobulin-binding domains
View	Download	0.918	0.000	cytoplasm	b.61.3	D-aminopeptidase, middle and C-terminal domains
View	Download	0.715	0.000	cytoplasm	b.61.3	D-aminopeptidase, middle and C-terminal domains
View	Download	0.636	0.000	cytoplasm	b.61.2	Metalloprotease inhibitor
View	Download	0.601	0.000	cytoplasm	b.122.1	PUA domain-like
View	Download	0.596	0.000	cytoplasm	b.43.4	Riboflavin synthase domain-like
View	Download	0.567	0.000	cytoplasm	d.74.2	C-terminal domain of arginine repressor
View	Download	0.541	0.000	cytoplasm	d.129.1	TATA-box binding protein-like
View	Download	0.528	0.000	cytoplasm	d.95.1	Glucose permease domain IIB
View	Download	0.496	0.000	cytoplasm	b.1.2	Fibronectin type III
View	Download	0.472	0.000	cytoplasm	b.43.4	Riboflavin synthase domain-like
View	Download	0.468	0.000	cytoplasm	b.71.1	Glycosyl hydrolase domain
View	Download	0.443	0.000	cytoplasm	d.66.1	Alpha-L RNA-binding motif
View	Download	0.443	0.000	cytoplasm	b.1.1	Immunoglobulin
View	Download	0.417	0.000	cytoplasm	b.43.4	Riboflavin synthase domain-like
View	Download	0.387	0.000	cytoplasm	b.1.1	Immunoglobulin
View	Download	0.379	0.000	cytoplasm	b.11.1	gamma-Crystallin-like
View	Download	0.375	0.000	cytoplasm	d.15.11	Doublecortin (DC)
View	Download	0.364	0.000	cytoplasm	b.61.2	Metalloprotease inhibitor
View	Download	0.363	0.000	cytoplasm	d.95.2	Homing endonucleases
View	Download	0.360	0.000	cytoplasm	g.28.1	Thyroglobulin type-1 domain
View	Download	0.356	0.000	cytoplasm	b.1.13	Superoxide reductase-like
View	Download	0.345	0.000	cytoplasm	b.43.4	Riboflavin synthase domain-like
View	Download	0.342	0.000	cytoplasm	d.197.1	Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
View	Download	0.329	0.000	cytoplasm	b.71.1	Glycosyl hydrolase domain
View	Download	0.318	0.000	cytoplasm	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.293	0.000	cytoplasm	b.1.4	beta-Galactosidase/glucuronidase domain
View	Download	0.289	0.000	cytoplasm	b.1.1	Immunoglobulin
View	Download	0.250	0.000	cytoplasm	d.17.3	Disulfide bond isomerase, DsbC, N-terminal domain
View	Download	0.235	0.000	cytoplasm	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.224	0.000	cytoplasm	d.102.1	Regulatory factor Nef
View	Download	0.221	0.000	cytoplasm	b.1.18	E set domains
View	Download	0.204	0.000	cytoplasm	b.1.2	Fibronectin type III

Predicted Domain #3

Region A:
Residues: [742-1286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YELDIDPILL SIFSHRFMDI ALQMGTQLRK TSVSTNVKER LDFSCALFDS KGNLVANAPH  60
   61 VPVHLGSMST CISAQAKLWE GKLKPGDVLI TNHPDIGGTH LPDITVITPS FSSTGELIFY 120
  121 VASRAHHADI GGILPGSVPP NSKELYEEGT AIYSELVVKE GIFQEELIYK LFVEDPGKYP 180
  181 GCSGSRRFSD NISDLKAQVA ANTKGIQLIG SLTKEYDLAT ILKYMAAIQT NASESIKKML 240
  241 AKMVEHFGTT KFSGEDRLDD GSLIKLQVII RPEKEEYIFN FDGTSPQVYG NLNAPEAITN 300
  301 SAILYCLRCL VGEDIPLNQG CLKPLTIKIP AGSLLSPRSG AAVVGGNVLT SQRVTDVILK 360
  361 TFNVMADSQG DCNNFTFGTG GNSGNKTDKQ IKGFGYYETI CGGSGAGADS WRGSGWNGSD 420
  421 AVHTNMTNTR MTDTEVFERR YPVLLKEFSI RRGSGGKGKY TGGNGVVRDV QFRKAVTASI 480
  481 LSERRVIGPH GIKGGQDGSR GENLWVRHST GALINVGGKN TIYAQPGDRF IIKTPGGGGF 540
  541 GQYKD

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	1000.0
Match:	PF02538
Description:	Hydantoinase B/oxoprolinase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [878-957]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVPPNSKELY EEGTAIYSEL VVKEGIFQEE LIYKLFVEDP GKYPGCSGSR RFSDNISDLK  60
   61 AQVAANTKGI QLIGSLTKEY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [958-1119]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLATILKYMA AIQTNASESI KKMLAKMVEH FGTTKFSGED RLDDGSLIKL QVIIRPEKEE  60
   61 YIFNFDGTSP QVYGNLNAPE AITNSAILYC LRCLVGEDIP LNQGCLKPLT IKIPAGSLLS 120
  121 PRSGAAVVGG NVLTSQRVTD VILKTFNVMA DSQGDCNNFT FG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1120-1181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGGNSGNKTD KQIKGFGYYE TICGGSGAGA DSWRGSGWNG SDAVHTNMTN TRMTDTEVFE  60
   61 RR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1182-1286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPVLLKEFSI RRGSGGKGKY TGGNGVVRDV QFRKAVTASI LSERRVIGPH GIKGGQDGSR  60
   61 GENLWVRHST GALINVGGKN TIYAQPGDRF IIKTPGGGGF GQYKD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: