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View Structure Prediction Details

Protein: TRP3
Organism: Saccharomyces cerevisiae
Length: 484 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRP3.

Description E-value Query
Range
Subject
Range
gi|207343703 - gi|207343703|gb|EDZ71087.1| YKL211Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409636 - gi|190409636|gb|EDV12901.1| anthranilate synthase component II [Saccharomyces cerevisiae RM11-1a]
gi|151941453 - gi|151941453|gb|EDN59817.1| anthranilate synthase component II [Saccharomyces cerevisiae YJM789]
TRP3 - Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase a...
TRPG_YEAST - Multifunctional tryptophan biosynthesis protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...
0.0 [1..484] [1..484]
gi|169014 - gi|169014|gb|AAA33633.1| trifunctional protein with glutamine amidotransferase (TrpG), phosphoribosy...
0.0 [15..483] [4..494]
TRPG_PENCH - Multifunctional tryptophan biosynthesis protein OS=Penicillium chrysogenum GN=trpC PE=3 SV=1
gi|211584265 - gi|211584265|emb|CAP92298.1| anthranilate synthase multifunctional protein trpC-Penicillium chrysoge...
0.0 [2..483] [8..503]
TRPG_NEUCR - Anthranilate synthase component 2 OS=Neurospora crassa GN=trp-1 PE=4 SV=2
TRPG_NEUCR - Multifunctional tryptophan biosynthesis protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A...
0.0 [2..483] [14..515]
TRPG_ASPNG - Multifunctional tryptophan biosynthesis protein OS=Aspergillus niger GN=trpC PE=3 SV=1
0.0 [2..483] [10..519]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..483] [10..519]
TRPG_EMENI - Anthranilate synthase component 2 OS=Emericella nidulans GN=trpC PE=2 SV=2
0.0 [2..483] [10..516]
TRPG_ASPAW - Multifunctional tryptophan biosynthesis protein OS=Aspergillus awamori GN=trpC PE=3 SV=1
gi|1069996 - gi|1069996|emb|CAA37640.1| unnamed protein product [Aspergillus niger]
0.0 [2..483] [10..517]

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Predicted Domain #1
Region A:
Residues: [1-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVHAATNPI NKHVVLIDNY DSFTWNVYEY LCQEGAKVSV YRNDAITVPE IAALNPDTLL  60
   61 ISPGPGHPKT DSGISRDCIR YFTGKIPVFG ICMGQQCMFD VFGGEVAYAG EIVHGKTSPI 120
  121 SHDNCGIFKN VPQGIAVTRY HSLAGTESSL PSCLKVTAST ENGIIMGVRH KKYTVEGVQF 180
  181 HPESILTEEG HLMIRNILNV SGGTWEENKS SPSNSILDRI YARRKIDVNE QSKIPGFTFQ 240
  241 DLQSNYDLGL AP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
anthranilate synthase activity 9.07528926783927 bayes_pls_golite062009
oxo-acid-lyase activity 7.16633518631507 bayes_pls_golite062009
4-amino-4-deoxychorismate synthase activity 4.48164623771604 bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity 4.14261580175621 bayes_pls_golite062009
ligase activity 1.70348758031146 bayes_pls_golite062009
catalytic activity 1.30391542469987 bayes_pls_golite062009
nucleic acid binding 0.86323855032533 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.628648036096965 bayes_pls_golite062009
binding 0.588714599255874 bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity 0.270391651600004 bayes_pls_golite062009
carbon-carbon lyase activity 0.0769356405014503 bayes_pls_golite062009
protein binding 0.0152024556625711 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [253-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLQDFYTVLS SSHKRAVVLA EVKRASPSKG PICLKAVAAE QALKYAEAGA SAISVLTEPH  60
   61 WFHGSLQDLV NVRKILDLKF PPKERPCVLR KEFIFSKYQI LEARLAGADT VLLIVKMLSQ 120
  121 PLLKELYSYS KDLNMEPLVE VNSKEELQRA LEIGAKVVGV NNRDLHSFNV DLNTTSNLVE 180
  181 SIPKDVLLIA LSGITTRDDA EKYKKEGVHG FLVGEALMKS TDVKKFIHEL CE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 387.201249
Match: 1igs__
Description: Indole-3-glycerophosphate synthase, IPGS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
indole-3-glycerol-phosphate synthase activity 8.59736519932798 bayes_pls_golite062009
anthranilate synthase activity 5.47492192345361 bayes_pls_golite062009
oxo-acid-lyase activity 4.09809510052304 bayes_pls_golite062009
tryptophan synthase activity 2.99898167480072 bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity 2.57188946638955 bayes_pls_golite062009
catalytic activity 2.44231061702877 bayes_pls_golite062009
carbon-carbon lyase activity 1.80077901589281 bayes_pls_golite062009
carboxy-lyase activity 1.32677036501434 bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity 0.966175242934785 bayes_pls_golite062009
binding 0.626392473915547 bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity 0.567370625225674 bayes_pls_golite062009
lyase activity 0.258652421339738 bayes_pls_golite062009
protein binding 0.014429239696785 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle