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View Structure Prediction Details

Protein: TGL1
Organism: Saccharomyces cerevisiae
Length: 548 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TGL1.

Description E-value Query
Range
Subject
Range
gi|151941667 - gi|151941667|gb|EDN60029.1| cholesterol esterase [Saccharomyces cerevisiae YJM789]
TGL1 - Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl este...
TGL1_YEAST - Sterol esterase TGL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TGL1 PE=1 SV=1
0.0 [1..548] [1..548]
gi|12844223 - gi|12844223|dbj|BAB26283.1| unnamed protein product [Mus musculus]
3.0E-89 [59..417] [27..392]
LIPG_RAT - Gastric triacylglycerol lipase OS=Rattus norvegicus GN=Lipf PE=1 SV=1
5.0E-89 [59..417] [27..392]

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Predicted Domain #1
Region A:
Residues: [1-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYFPFLGRLS ITDYIIVVLV YIESIISSVL KLIPQPMINL FEWLINFSTS SDDNTIEEKL  60
   61 RSAPTIHEMC AIFDISVEDH LVRTEDNYIL TLHRIPPISK NRFNNKVVYL HHGLLMCSDV 120
  121 WCCNIERHKN LPFVLHDLGY DVWMGNNRGN KYSTAHLNKP PKSNKFWDFS IDEFAFFDIP 180
  181 NSIEFILDIT KVDKVICIGF SQGSAQMFAA FSLSEKLNRK VSHFIAIAPA MTPKGLHNRI 240
  241 VDTLAKSSPG FMYLFFGRKI VLPSAVIWQR TLHPTLFNLC IDIANKILFN WKSFNILPRQ 300
  301 KIASYAKLYS TTSVKSIVHW FQILRSQKFQ MFEESDNMLN SLTRPYQIAN FPTRTNIKIP 360
  361 ILLIYGGIDS LVDIDVMKKN LPFNSVFDVK VDNYEHLDLI WGKDADTLVI AKVLRFIEFF 420
  421 NPGNVSVKTN QLLPSASLVE ELPSTTWKTT HPTHGLSYRT HSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 526.554485
Match: 1k8qA_
Description: Gastric lipase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.20549979663539 bayes_pls_golite062009
malate dehydrogenase activity 2.28093794718528 bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity 2.14423515928317 bayes_pls_golite062009
catalytic activity 1.39629727416851 bayes_pls_golite062009
triglyceride lipase activity 1.2959733599348 bayes_pls_golite062009
sterol esterase activity 1.21262745914703 bayes_pls_golite062009
thiolester hydrolase activity 1.18565704009692 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.985235528680562 bayes_pls_golite062009
palmitoyl-CoA hydrolase activity 0.92549140936125 bayes_pls_golite062009
peptidase activity 0.858311047004898 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.590445773074315 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
binding 0.351031277062254 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [464-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRSPLSVQAD EADEVHNADN SRFLRRVFST SAIDEDNENE HQDDTEDQIH KEQQRRLSAY  60
   61 LESSKDLRQL DANSSTTALD ALNKE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.355 a.64.1 Saposin
View Download 0.546 a.24.17 Group V grass pollen allergen
View Download 0.384 a.11.1 Acyl-CoA binding protein
View Download 0.486 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.377 a.51.1 Cytochrome c oxidase subunit h
View Download 0.546 a.24.17 Group V grass pollen allergen
View Download 0.486 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.384 a.11.1 Acyl-CoA binding protein
View Download 0.377 a.51.1 Cytochrome c oxidase subunit h
View Download 0.355 a.64.1 Saposin
View Download 0.351 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.342 i.1.1 Ribosome and ribosomal fragments
View Download 0.310 a.2.3 Chaperone J-domain
View Download 0.287 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.286 a.24.3 Cytochromes
View Download 0.280 a.24.17 Group V grass pollen allergen
View Download 0.269 a.40.1 Calponin-homology domain, CH-domain
View Download 0.268 a.50.1 Anaphylotoxins (complement system)
View Download 0.248 a.24.4 Hemerythrin
View Download 0.245 a.24.17 Group V grass pollen allergen
View Download 0.240 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.238 a.77.1 DEATH domain
View Download 0.223 a.2.3 Chaperone J-domain
View Download 0.223 a.64.1 Saposin
View Download 0.222 i.1.1 Ribosome and ribosomal fragments
View Download 0.221 a.26.1 4-helical cytokines
View Download 0.219 a.4.5 "Winged helix" DNA-binding domain
View Download 0.209 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.200 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle