YRC Public Data Repository - Protein Structure Prediction

Protein:	MGM101
Organism:	Saccharomyces cerevisiae
Length:	269 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MGM101.

Description	E-value	Query Range	Subject Range
MGM101 - Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, requi... gi\|190409612 - gi\|190409612\|gb\|EDV12877.1\| mitochondrial nucleoid protein [Saccharomyces cerevisiae RM11-1a] MG101_YEAST - Mitochondrial genome maintenance protein MGM101 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...	0.0	[1..269]	[1..269]
M101_KLULA, MG10... - Mitochondrial genome maintenance protein MGM101 OS=Kluyveromyces lactis GN=MGM101 PE=3 SV=2, (Q00970... MG101_KLULA - Mitochondrial genome maintenance protein MGM101 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359...	0.0	[21..269]	[24..262]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[21..269]	[24..262]
mgm101 - mitochondrial nucleoid protein MG101_SCHPO - Mitochondrial genome maintenance protein mgm101 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2484...	9.0E-93	[78..269]	[73..265]

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Predicted Domain #1

Region A:
Residues: [1-77]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSIFKVRGC VSHAAQFCQK RTVVSTGTSN TATAGAVRKS FNSTETKPVF ATKSEAGNGS  60
   61 HMKEYSSGIN SKLGGTP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.824	0.059	mitochondrial genome maintenance	d.68.3	SirA-like
View	Download	0.534	0.059	mitochondrial genome maintenance	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.523	0.059	mitochondrial genome maintenance	d.68.7	R3H domain
View	Download	0.824	0.059	mitochondrial genome maintenance	d.68.3	SirA-like
View	Download	0.782	0.059	mitochondrial genome maintenance	d.68.3	SirA-like
View	Download	0.669	0.059	mitochondrial genome maintenance	d.68.3	SirA-like
View	Download	0.625	0.059	mitochondrial genome maintenance	d.68.3	SirA-like
View	Download	0.611	0.059	mitochondrial genome maintenance	d.68.6	DNA-binding protein Sso10b (AlbA)
View	Download	0.611	0.059	mitochondrial genome maintenance	d.68.6	DNA-binding protein Sso10b (AlbA)
View	Download	0.513	0.059	mitochondrial genome maintenance	a.64.1	Saposin
View	Download	0.427	0.059	mitochondrial genome maintenance	a.39.1	EF-hand
View	Download	0.410	0.059	mitochondrial genome maintenance	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.408	0.059	mitochondrial genome maintenance	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.400	0.059	mitochondrial genome maintenance	c.84.1	Phosphoglucomutase, first 3 domains
View	Download	0.398	0.059	mitochondrial genome maintenance	a.64.1	Saposin
View	Download	0.395	0.059	mitochondrial genome maintenance	a.21.1	HMG-box
View	Download	0.390	0.059	mitochondrial genome maintenance	c.23.1	CheY-like
View	Download	0.388	0.059	mitochondrial genome maintenance	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.378	0.059	mitochondrial genome maintenance	c.25.1	Ferredoxin reductase-like, C-terminal NADP-linked domain
View	Download	0.374	0.059	mitochondrial genome maintenance	a.64.1	Saposin
View	Download	0.370	0.059	mitochondrial genome maintenance	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.359	0.059	mitochondrial genome maintenance	a.4.1	Homeodomain-like
View	Download	0.350	0.059	mitochondrial genome maintenance	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.347	0.059	mitochondrial genome maintenance	c.10.1	RNI-like
View	Download	0.346	0.059	mitochondrial genome maintenance	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.339	0.059	mitochondrial genome maintenance	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.337	0.059	mitochondrial genome maintenance	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.329	0.059	mitochondrial genome maintenance	d.39.1	Dynein light chain 8 (DLC8)
View	Download	0.324	0.059	mitochondrial genome maintenance	c.20.1	Initiation factor IF2/eIF5b, domain 3
View	Download	0.322	0.059	mitochondrial genome maintenance	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.306	0.059	mitochondrial genome maintenance	c.49.1	Pyruvate kinase, C-terminal domain
View	Download	0.305	0.059	mitochondrial genome maintenance	c.32.1	Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View	Download	0.296	0.059	mitochondrial genome maintenance	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.294	0.059	mitochondrial genome maintenance	a.64.2	Bacteriocin AS-48
View	Download	0.284	0.059	mitochondrial genome maintenance	c.102.1	Cell-division inhibitor MinC, N-terminal domain
View	Download	0.280	0.059	mitochondrial genome maintenance	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.276	0.059	mitochondrial genome maintenance	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.275	0.059	mitochondrial genome maintenance	a.60.2	RuvA domain 2-like
View	Download	0.267	0.059	mitochondrial genome maintenance	d.68.5	C-terminal domain of ProRS
View	Download	0.265	0.059	mitochondrial genome maintenance	a.181.1	Antibiotic binding domain of TipA-like multidrug resistance regulators
View	Download	0.260	0.059	mitochondrial genome maintenance	a.74.1	Cyclin-like
View	Download	0.256	0.059	mitochondrial genome maintenance	a.60.3	C-terminal domain of RNA polymerase alpha subunit
View	Download	0.256	0.059	mitochondrial genome maintenance	a.4.1	Homeodomain-like
View	Download	0.252	0.059	mitochondrial genome maintenance	a.17.1	p8-MTCP1
View	Download	0.252	0.059	mitochondrial genome maintenance	c.114.1	YchN-like
View	Download	0.246	0.059	mitochondrial genome maintenance	a.77.1	DEATH domain
View	Download	0.244	0.059	mitochondrial genome maintenance	a.4.1	Homeodomain-like
View	Download	0.239	0.059	mitochondrial genome maintenance	c.40.1	Methylesterase CheB, C-terminal domain
View	Download	0.237	0.059	mitochondrial genome maintenance	a.36.1	Signal peptide-binding domain
View	Download	0.235	0.059	mitochondrial genome maintenance	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.229	0.059	mitochondrial genome maintenance	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.229	0.059	mitochondrial genome maintenance	a.12.1	Kix domain of CBP (creb binding protein)
View	Download	0.226	0.059	mitochondrial genome maintenance	f.34.1	Mechanosensitive channel protein MscS (YggB), transmembrane region
View	Download	0.225	0.059	mitochondrial genome maintenance	a.42.1	MDM2
View	Download	0.219	0.059	mitochondrial genome maintenance	c.1.2	Ribulose-phoshate binding barrel
View	Download	0.215	0.059	mitochondrial genome maintenance	c.23.1	CheY-like
View	Download	0.214	0.059	mitochondrial genome maintenance	a.77.1	DEATH domain
View	Download	0.212	0.059	mitochondrial genome maintenance	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.209	0.059	mitochondrial genome maintenance	a.112.1	Description not found.
View	Download	0.206	0.059	mitochondrial genome maintenance	a.2.3	Chaperone J-domain
View	Download	0.204	0.059	mitochondrial genome maintenance	d.53.1	Ribosomal protein S3 C-terminal domain
View	Download	0.201	0.059	mitochondrial genome maintenance	c.37.1	P-loop containing nucleoside triphosphate hydrolases

Predicted Domain #2

Region A:
Residues: [78-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LETRSTADDS LNNSYKQVKG DIDWYTSWYG LGMKPFEAKV QKDLIEPLDP KDIEIKPDGL  60
   61 IYLPEIKYRR ILNKAFGAGG WGLVPRSQTI VTSKLVTREY GLICHGQLIS VARGEQDYFN 120
  121 EAGIPTATEG CKSNALMRCC KDLGVGSELW DPVFIKKFKV DHCTEKFVEH VTTKRKKKIW 180
  181 LRKDRQVEYP YK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.58949805002675	bayes_pls_golite062009
nucleic acid binding	1.86070042016282	bayes_pls_golite062009
protein binding	1.54537643602694	bayes_pls_golite062009
structure-specific DNA binding	1.24523960036293	bayes_pls_golite062009
DNA-dependent ATPase activity	0.872400487455321	bayes_pls_golite062009
RNA binding	0.686982923008616	bayes_pls_golite062009
structural constituent of ribosome	0.635289190073156	bayes_pls_golite062009
structural molecule activity	0.552042000067166	bayes_pls_golite062009
DNA binding	0.458518652485702	bayes_pls_golite062009
DNA helicase activity	0.404666699673269	bayes_pls_golite062009
cytoskeletal protein binding	0.395139311341453	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.143807478857287	bayes_pls_golite062009
catalytic activity	0.00430305721638241	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: