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View Structure Prediction Details

Protein: YJR129C
Organism: Saccharomyces cerevisiae
Length: 339 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YJR129C.

Description E-value Query
Range
Subject
Range
YJR129C - Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of ...
6.0E-77 [1..339] [1..339]
gi|14603247, gi|... - gi|14603247|gb|AAH10084.1| Family with sequence similarity 86, member A [Homo sapiens], gi|119605642...
3.0E-56 [15..310] [30..312]
gi|7228478 - gb|AAF42473.1| actinomycin synthetase III [Streptomyces chrysomallus]
gi|7228478 - gi|7228478|gb|AAF42473.1|AF204401_1 actinomycin synthetase III [Streptomyces chrysomallus]
1.0E-31 [55..298] [1935..2165]
gi|15029321 - gi|15029321|gb|AAK81826.1| peptide synthetase [Streptomyces lavendulae]
9.0E-31 [47..298] [3864..4112]
gi|18920646 - gi|18920646|gb|AAL82382.1| McyA [Microcystis aeruginosa]
2.0E-30 [63..313] [682..936]
gi|6007553 - gi|6007553|gb|AAF00960.1| McyA [Microcystis aeruginosa PCC 7806]
gi|6007553 - gi|6007553|gb|AAF00960.1|AF183408_8 McyA [Microcystis aeruginosa PCC 7806]
5.0E-29 [63..313] [674..928]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEDLFYDRL HQRCPGKYLL EELETSKSND VLHASRFVCE MELVQKTNAY YCKTIVKMLL  60
   61 DHEWIFAKAF TIVNDGEDEI EIYDYLYEKY IKLLSTGKPD PMMKDVVRYR FDEDVKITIE 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.456 0.018 cytoplasm a.77.1 DEATH domain
View Download 0.487 0.007 S-adenosylmethionine-dependent methyltransferase activity c.23.10 SGHN hydrolase
View Download 0.494 0.003 cytoplasm d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.562 0.001 S-adenosylmethionine-dependent methyltransferase activity a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.574 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.453 N/A N/A c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.433 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.425 N/A N/A a.25.1 Ferritin-like
View Download 0.369 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.361 N/A N/A c.95.1 Thiolase-like
View Download 0.351 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.348 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.323 N/A N/A d.58.1 4Fe-4S ferredoxins
View Download 0.303 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.300 N/A N/A f.1.1 Colicin
View Download 0.293 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.287 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.286 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.277 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.261 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.241 N/A N/A a.118.8 TPR-like
View Download 0.233 N/A N/A c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.232 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.230 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.219 N/A N/A a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.218 N/A N/A d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.218 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.214 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 N/A N/A d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.200 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted functions:

Term Confidence Notes
methyltransferase activity 3.57681394097837 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 3.49392219433935 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
rRNA methyltransferase activity 2.5924681776558 bayes_pls_golite062009
transferase activity 2.22303238506686 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
tRNA methyltransferase activity 1.12859857407629 bayes_pls_golite062009
N-methyltransferase activity 0.891400969900644 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.794703281700029 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.716476158062361 bayes_pls_golite062009
protein methyltransferase activity 0.348134584790547 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 0.0854264678700428 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [122-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPNLISAAST TGFRTWEAAL YMGDFLIHKP LQELAPVQGQ DDGKKKLNVL EVGAGTGIVS  60
   61 LVILQKYHEF VNKMYVTDGD SNLVETQLKR NFELNNEVRE NEPDIKLQRL WWGSDRVPED 120
  121 IDLVVGADVT YDPTILPDLC ECLAECLALD RCKLCLLSAT IRSESTVQLF SQECNKLGLK 180
  181 CTIVTSTEYD ANNEIRAMKA LQFKPLIAPI RIYKITKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle