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View Structure Prediction Details

Protein: ISY1
Organism: Saccharomyces cerevisiae
Length: 235 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISY1.

Description E-value Query
Range
Subject
Range
ISY1_YEAST - Pre-mRNA-splicing factor ISY1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISY1 PE=1 ...
ISY1 - Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of ...
gi|190409527 - gi|190409527|gb|EDV12792.1| pre-mRNA splicing factor ISY1 [Saccharomyces cerevisiae RM11-1a]
3.0E-86 [1..235] [1..235]
gi|6330157 - gi|6330157|dbj|BAA86474.1| KIAA1160 protein [Homo sapiens]
2.0E-79 [1..232] [21..286]
CG9667-PA - This gene is referred to in FlyBase by the symbol Dmel\CG9667 (CG9667, FBgn0037550). It is a protein...
9.0E-73 [1..232] [1..266]
ISY1_MOUSE - Pre-mRNA-splicing factor ISY1 homolog OS=Mus musculus GN=Isy1 PE=1 SV=2
4.0E-71 [1..232] [1..266]
CE05922 - status:Confirmed UniProt:Q20716 protein_id:CAA96652.1
2.0E-68 [1..232] [1..264]
cwf12 - complexed with Cdc5 protein Cwf12
ISY1_SCHPO - Pre-mRNA-splicing factor cwf12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cwf12 PE=1 ...
2.0E-64 [29..234] [11..217]
gi|9293904, gi|2... - gi|9293904|dbj|BAB01807.1| unnamed protein product [Arabidopsis thaliana], gi|26452139|dbj|BAC43158....
2.0E-57 [1..232] [1..279]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRNVDKANS VLVRFQEQQA ESAGGYKDYS RYQRPRNVSK VKSIKEANEW KRQVSKEIKQ  60
   61 KSTRIYDPSL NEMQIAELND ELNNLFKEWK RWQWHIDHTL MEKK

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.55
Match: 1cunA
Description: Spectrin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.7761451438984 bayes_pls_golite062009
cytoskeletal protein binding 2.28760768499625 bayes_pls_golite062009
structural molecule activity 2.18199613481266 bayes_pls_golite062009
actin binding 2.06460396235438 bayes_pls_golite062009
protein binding 2.03402581943916 bayes_pls_golite062009
actin filament binding 1.58451318432641 bayes_pls_golite062009
transcription regulator activity 1.33758861760616 bayes_pls_golite062009
protein complex binding 0.704042118621314 bayes_pls_golite062009
identical protein binding 0.123910502598633 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [105-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKRKRLEDSH VLMNSGKLIN GKRYFGRALE LPEVKEWLKQ SQRQNDGGSI NTKCIPKDRN  60
   61 DFYYHGKVTA ALTEFEANWT SILKAHYNVP VNEDEEEMSR QTQEIHVPTL ADMEHWLVQR 120
  121 RKKKLMDELN L

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.55
Match: 1cunA
Description: Spectrin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.7761451438984 bayes_pls_golite062009
cytoskeletal protein binding 2.28760768499625 bayes_pls_golite062009
structural molecule activity 2.18199613481266 bayes_pls_golite062009
actin binding 2.06460396235438 bayes_pls_golite062009
protein binding 2.03402581943916 bayes_pls_golite062009
actin filament binding 1.58451318432641 bayes_pls_golite062009
transcription regulator activity 1.33758861760616 bayes_pls_golite062009
protein complex binding 0.704042118621314 bayes_pls_golite062009
identical protein binding 0.123910502598633 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle