YRC Public Data Repository - Protein Structure Prediction

Protein:	CPS1
Organism:	Saccharomyces cerevisiae
Length:	576 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPS1.

Description	E-value	Query Range	Subject Range
CBPS_YEAST - Carboxypeptidase S OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CPS1 PE=1 SV=2 CPS1 - Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	0.0	[1..576]	[1..576]
gi\|15620780 - gi\|15620780\|emb\|CAC69883.1\| glutamate carboxypeptidase [Homo sapiens]	2.0E-67	[79..575]	[7..473]
CNDP2_MOUSE - Cytosolic non-specific dipeptidase OS=Mus musculus GN=Cndp2 PE=1 SV=1	6.0E-66	[79..575]	[7..473]
YE48_SCHPO - Uncharacterized carboxypeptidase C24C9.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=... SPAC24C9.08 - vacuolar carboxypeptidase	9.0E-66	[60..569]	[84..587]
pes-9 - Yeast hypothetical 52.9 KD protein like status:Confirmed UniProt:O18000 protein_id:CAB07646.1	2.0E-63	[75..574]	[4..472]
gi\|25520910 - pir\|\|G97371 argE/dapE/acy1 family protein [imported] - Agrobacterium tumefaciens (strain C58, Cereon... gi\|15154979, gi\|... - gi\|15887462\|ref\|NP_353143.1\| hypothetical protein AGR_C_165 [Agrobacterium tumefaciens str. C58], gi...	2.0E-61	[45..573]	[7..505]
gi\|15827662 - gi\|15827662\|ref\|NP_301925.1\| hypothetical protein ML1288 [Mycobacterium leprae TN] gi\|13093213, gi\|... - pir\|\|B87070 probable peptidase [imported] - Mycobacterium leprae, gi\|13093213\|emb\|CAC31669.1\| possib... gi\|221230139, gi... - gi\|221230139\|ref\|YP_002503555.1\| putative peptidase [Mycobacterium leprae Br4923], gi\|219933246\|emb\|...	4.0E-58	[87..569]	[31..464]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIALPVEKAP RKSLWQRHRA FISGIVALII IGTFFLTSGL HPAPPHEAKR PHHGKGPMHS  60
   61 PKCEKIEP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.222	d.15.1	Ubiquitin-like
View	Download	0.221	a.156.1	S13-like H2TH domain
View	Download	0.430	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.579	d.74.5	Hypothetical protein Yml108w
View	Download	0.579	d.74.5	Hypothetical protein Yml108w
View	Download	0.430	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.222	d.15.1	Ubiquitin-like
View	Download	0.221	a.156.1	S13-like H2TH domain

Predicted Domain #2

Region A:
Residues: [69-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSPSFKHSVD TILHDPAFRN SSIEKLSNAV RIPTVVQDKN PNPADDPDFY KHFYELHDYF  60
   61 EKTFPNIHKH LKLEKVNELG LLYTWEGSDP DLKPLLLMAH QDVVPVNNET LSSWKFPPFS 120
  121 GHYDPETDFV WGRGSNDCKN LLIAEFEAIE QLLIDGFKPN RTIVMSLGFD EEASGTLGAA 180
  181 SLASFLHERY GDDGIYSIID EGEGIMEVDK DVFVATPINA EKG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [401-479]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVKANALPET TRFLINHRIN LHSSVAEVFE RNIEYAKKIA EKYGYGLSKN GDDYIIPETE  60
   61 LGHIDITLLR ELEPAPLSP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1cg2A_
Description:	Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	4.61719816036179	bayes_pls_golite062009
peptidase activity	4.41512153958838	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.59809762149163	bayes_pls_golite062009
catalytic activity	2.00064748759729	bayes_pls_golite062009
exopeptidase activity	0.906571162336786	bayes_pls_golite062009
binding	0.767655217795721	bayes_pls_golite062009
endopeptidase activity	0.529831416345723	bayes_pls_golite062009
carboxypeptidase activity	0.389857234977383	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [292-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVDFEVSILG HGGHSSVPPD HTTIGIASEL ITEFEANPFD YEFEFDNPIY GLLTCAAEHS  60
   61 KSLSKDVKKT ILGAPFCPRR KDKLVEYISN QSHLRSLIRT TQAVDIING

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1cg2A_
Description:	Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [480-576]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGPVWDILA GTIQDVFENG VLQNNEEFYV TTGLFSGNTD TKYYWNLSKN IYRFVGSIID  60
   61 IDLLKTLHSV NEHVDVPGHL SAIAFVYEYI VNVNEYA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.46
Match:	1lfwA
Description:	Aminopeptidase PepV
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: