YRC Public Data Repository - Protein Structure Prediction

Protein:	AIM22
Organism:	Saccharomyces cerevisiae
Length:	451 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AIM22.

Description	E-value	Query Range	Subject Range
gi\|25293701 - pir\|\|C83735 lipoate-protein ligase lplA [imported] - Bacillus halodurans (strain C-125) gi\|10173297, gi\|... - gi\|15613246\|ref\|NP_241549.1\| lipoate-protein ligase [Bacillus halodurans C-125], gi\|10173297\|dbj\|BAB...	4.0E-72	[159..438]	[3..284]
gi\|221313187 - gi\|221313187\|ref\|ZP_03594992.1\| hypothetical protein BsubsN3_05622 [Bacillus subtilis subsp. subtili... LPLJ_BACSU - Lipoate-protein ligase LplJ OS=Bacillus subtilis (strain 168) GN=lplJ PE=1 SV=1 gi\|221322385 - gi\|221322385\|ref\|ZP_03603679.1\| hypothetical protein BsubsS_05677 [Bacillus subtilis subsp. subtilis... gi\|221318110 - gi\|221318110\|ref\|ZP_03599404.1\| hypothetical protein BsubsJ_05571 [Bacillus subtilis subsp. subtilis... LPLJ_BACSU, LPLA... - Lipoate-protein ligase LplJ OS=Bacillus subtilis GN=lplJ PE=1 SV=1, Putative lipoate-protein ligase ...	5.0E-72	[159..438]	[3..285]
gi\|25497293, gi\|... - pir\|\|C86138 probable lipoate-protein ligase A Z5988 [imported] - Escherichia coli (strain O157:H7, s... gi\|15804958, gi\|... - gi\|15804958\|ref\|NP_291000.1\| lipoate-protein ligase A [Escherichia coli O157:H7 EDL933], gi\|12519413... gi\|15834599, gi\|... - gi\|15834599\|ref\|NP_313372.1\| lipoate-protein ligase A [Escherichia coli O157:H7], gi\|13364823\|dbj\|BA... gi\|209160717, gi... - gi\|209399317\|ref\|YP_002273907.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4115], gi\|20... gi\|254796382, gi... - gi\|254796382\|ref\|YP_003081219.1\| putative lipoate-protein ligase A [Escherichia coli O157:H7 str. TW... gi\|217320954, gi... - gi\|217324733\|ref\|ZP_03440817.1\| protein smp precursor [Escherichia coli O157:H7 str. TW14588], gi\|21... gi\|189405597, gi... - gi\|189405597\|ref\|ZP_02822967.2\| protein smp precursor [Escherichia coli O157:H7 str. EC508], gi\|1893... gi\|208807122, gi... - gi\|208807122\|ref\|ZP_03249459.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|208733311, gi... - gi\|208812034\|ref\|ZP_03253363.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4045], gi\|208... gi\|208739646, gi... - gi\|208819523\|ref\|ZP_03259843.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4042], gi\|208... gi\|189356110, gi... - gi\|189402353\|ref\|ZP_02781813.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4401], gi\|189... gi\|189363979, gi... - gi\|189402794\|ref\|ZP_02791676.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4486], gi\|189... gi\|189367001, gi... - gi\|189404204\|ref\|ZP_02787747.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4501], gi\|189... gi\|189374913, gi... - gi\|189404619\|ref\|ZP_02810038.2\| protein smp precursor [Escherichia coli O157:H7 str. EC869], gi\|1893... gi\|187767992, gi... - gi\|187776280\|ref\|ZP_02801641.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4196], gi\|187... gi\|188025097, gi... - gi\|188025097\|ref\|ZP_02775997.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4113], gi\|188... gi\|189010377, gi... - gi\|189010377\|ref\|ZP_02806684.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4076], gi\|189... gi\|15834599, gi\|... - gi\|15834599\|ref\|NP_313372.1\| unknown domain/lipoate-protein ligase A fusion protein [Escherichia col...	4.0E-71	[150..432]	[221..505]
EG11796 - lipoate-protein ligase A / Lipoate-protein ligase A; selenolipoate resistant LPLA_ECOLI - Lipoate-protein ligase A (EC 6.3.2.-) - Escherichia coli LPLA_ECOBW - Lipoate-protein ligase A OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=lplA PE=3 SV=1 EG11796 - lipoate-protein ligase A / Lipoate-protein ligase A; selenolipoate resistant LPLA_ECODH - Lipoate-protein ligase A OS=Escherichia coli (strain K12 / DH10B) GN=lplA PE=3 SV=1 gi\|89111094, gi\|... - gi\|89111094\|ref\|AP_004874.1\| lipoate-protein ligase A [Escherichia coli str. K-12 substr. W3110], gi...	3.0E-70	[154..432]	[1..281]
LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=lplA PE=... lcl\|NC_016856.1_... - [gene=lplA] [protein=lipoate-protein ligase A] [protein_id=YP_005240921.1] [location=complement(4844... gi\|197244278, gi... - gi\|197266023\|ref\|ZP_03166097.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium GN=lplA PE=3 SV=1 LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium GN=lplA PE=3 SV=1 gi\|167989818, gi... - gi\|205331409\|gb\|EDZ18173.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar 4,... gi\|205336596, gi... - gi\|205336596\|gb\|EDZ23360.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar He... LPLA_SALHS - Lipoate-protein ligase A OS=Salmonella heidelberg (strain SL476) GN=lplA PE=3 SV=1	3.0E-69	[154..431]	[1..280]
gi\|214000694 - gi\|214000694\|ref\|ZP_03411429.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213852198 - gi\|213852198\|ref\|ZP_03381730.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... LPLA_SALTI - Lipoate-protein ligase A OS=Salmonella typhi GN=lplA PE=3 SV=1 LPLA_SALTI - Lipoate-protein ligase A OS=Salmonella typhi GN=lplA PE=3 SV=1 gi\|16763367 - gi\|16763367\|ref\|NP_458984.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar T... gi\|213416956 - gi\|213416956\|ref\|ZP_03350100.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|29144845, gi\|... - gi\|29144845\|ref\|NP_808187.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar T... gi\|213051977 - gi\|213051977\|ref\|ZP_03344855.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213650710 - gi\|213650710\|ref\|ZP_03380763.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213612470 - gi\|213612470\|ref\|ZP_03370296.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213582043 - gi\|213582043\|ref\|ZP_03363869.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213427577 - gi\|213427577\|ref\|ZP_03360327.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova...	3.0E-69	[154..431]	[1..280]
gi\|269202641\|ref... - lipoate-protein ligase A family protein [Staphylococcus aureus subsp. aureus ED98] gi\|253316187 - gi\|253316187\|ref\|ZP_04839400.1\| lipoate-protein ligase-like protein [Staphylococcus aureus subsp. au... gi\|255005815 - gi\|255005815\|ref\|ZP_05144416.2\| lipoate-protein ligase-like protein [Staphylococcus aureus subsp. au... LPLA1_STAAM - Lipoate--protein ligase 1 OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=SAV1028 PE=1 SV=1 gi\|15926615, gi\|... - gi\|15926615\|ref\|NP_374148.1\| hypothetical protein SA0884 [Staphylococcus aureus subsp. aureus N315],... gi\|156721487, gi... - gi\|156979352\|ref\|YP_001441611.1\| lipoate-protein ligase-like protein [Staphylococcus aureus subsp. a... gi\|150393576, gi... - gi\|150393576\|ref\|YP_001316251.1\| lipoyltransferase and lipoate-protein ligase [Staphylococcus aureus... gi\|25293704 - pir\|\|C89871 hypothetical protein SA0884 [imported] - Staphylococcus aureus (strain N315) gi\|148267520, gi... - gi\|148267520\|ref\|YP_001246463.1\| lipoyltransferase and lipoate-protein ligase [Staphylococcus aureus...	1.0E-68	[159..438]	[3..282]
gi\|16800002 - gi\|16800002\|ref\|NP_470270.1\| hypothetical protein lin0931 [Listeria innocua Clip11262] gi\|16413379, gi\|... - pir\|\|AC1549 lipoate protein ligase A homolog lin0931 [imported] - Listeria innocua (strain Clip11262...	2.0E-68	[159..439]	[3..286]
gi\|225854635, gi... - gi\|225854635\|ref\|YP_002736147.1\| lipoate protein ligase A [Streptococcus pneumoniae JJA], gi\|2257232... gi\|25293702 - pir\|\|D95134 lipoate-protein ligase, probable [imported] - Streptococcus pneumoniae (strain TIGR4) gi\|66879185, gi\|... - gi\|66879185\|ref\|ZP_00404213.1\| COG0095: Lipoate-protein ligase A [Streptococcus pneumoniae TIGR4], g...	4.0E-68	[161..439]	[4..283]
gi\|168483222, gi... - gi\|172043498\|gb\|EDT51544.1\| lipoate protein ligase A [Streptococcus pneumoniae CDC1873-00], gi\|16848... gi\|25293705 - pir\|\|G98002 lipoate protein ligase A (EC 6.-.-.-) [imported] - Streptococcus pneumoniae (strain R6) gi\|15458668, gi\|... - gi\|15903091\|ref\|NP_358641.1\| lipoate-protein ligase, putative [Streptococcus pneumoniae R6], gi\|1545... gi\|116077327, gi... - gi\|116516751\|ref\|YP_816498.1\| lipoate-protein ligase, putative [Streptococcus pneumoniae D39], gi\|11... gi\|148985768, gi... - gi\|148985768\|ref\|ZP_01818896.1\| lipoate-protein ligase, putative [Streptococcus pneumoniae SP3-BS71]... gi\|225725441, gi... - gi\|225856837\|ref\|YP_002738348.1\| lipoate protein ligase A [Streptococcus pneumoniae P1031], gi\|22572...	6.0E-68	[161..439]	[4..283]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSASSYLIR NIEHPKISEL TYVEFLMNTK EENTRLFFDV YIMSMMLSNW ALSPRYVGQR  60
   61 NLIHCTTLFH TLTRWAKDAD DKYHDINSMY ENMFTPSNDN VSILQDEGKS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [111-228]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYDTTKASSM EEDISAFNKD LYNFYNIGYA KQIMSASQLE NIVKAKGRFV IQSLSTSPYY  60
   61 NLALENYVFK NTPRAKRGPD NCRLLFYIND RCAVIGKNQN LWQEVDLAKL KSKNFELL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
aminoacyl-tRNA ligase activity	4.11741584670871	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	4.11627822082383	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	4.11627822082383	bayes_pls_golite062009
ligase activity	2.91948094816945	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	0.729947203019949	bayes_pls_golite062009
threonine-tRNA ligase activity	0.240788175151445	bayes_pls_golite062009
serine-tRNA ligase activity	0.228481182681194	bayes_pls_golite062009
glycine-tRNA ligase activity	0.150020288395523	bayes_pls_golite062009
binding	0.0498327097792011	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [229-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRFSGGGTVL HDLGNVNYSY LTSREKFETK FFNKMIIKWL NSLNPELRLD LNERGDIIQD  60
   61 GFKISGSAYK IAGGKAYHHA TMLLNADLEQ FSGLLEPSLP NNMEWESSGV HSVKSKIKNV 120
  121 GIITPNQFIA VVSERFQKTF KVDGEIPIYY CDEFKSINDE IKDAMNTLQS EQWKYFSGPK 180
  181 FSVKIKDKGL TIKVEKGMIY DCDRNDLIGL EFKGFLENID SYT

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.24
Match:	1hxdA
Description:	Biotin repressor, N-terminal domain; Biotin repressor/biotin holoenzyme synthetase, C-terminal domain; Biotin repressor/biotin holoenzyme synthetase, catalytic (central) domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: