YRC Public Data Repository - Protein Structure Prediction

Protein:	AIM22
Organism:	Saccharomyces cerevisiae
Length:	451 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AIM22.

Description	E-value	Query Range	Subject Range
gi\|25293701 - pir\|\|C83735 lipoate-protein ligase lplA [imported] - Bacillus halodurans (strain C-125) gi\|10173297, gi\|... - gi\|15613246\|ref\|NP_241549.1\| lipoate-protein ligase [Bacillus halodurans C-125], gi\|10173297\|dbj\|BAB...	4.0E-72	[159..438]	[3..284]
gi\|221313187 - gi\|221313187\|ref\|ZP_03594992.1\| hypothetical protein BsubsN3_05622 [Bacillus subtilis subsp. subtili... LPLJ_BACSU - Lipoate-protein ligase LplJ OS=Bacillus subtilis (strain 168) GN=lplJ PE=1 SV=1 gi\|221322385 - gi\|221322385\|ref\|ZP_03603679.1\| hypothetical protein BsubsS_05677 [Bacillus subtilis subsp. subtilis... gi\|221318110 - gi\|221318110\|ref\|ZP_03599404.1\| hypothetical protein BsubsJ_05571 [Bacillus subtilis subsp. subtilis... LPLJ_BACSU, LPLA... - Lipoate-protein ligase LplJ OS=Bacillus subtilis GN=lplJ PE=1 SV=1, Putative lipoate-protein ligase ...	5.0E-72	[159..438]	[3..285]
gi\|25497293, gi\|... - pir\|\|C86138 probable lipoate-protein ligase A Z5988 [imported] - Escherichia coli (strain O157:H7, s... gi\|15804958, gi\|... - gi\|15804958\|ref\|NP_291000.1\| lipoate-protein ligase A [Escherichia coli O157:H7 EDL933], gi\|12519413... gi\|15834599, gi\|... - gi\|15834599\|ref\|NP_313372.1\| lipoate-protein ligase A [Escherichia coli O157:H7], gi\|13364823\|dbj\|BA... gi\|209160717, gi... - gi\|209399317\|ref\|YP_002273907.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4115], gi\|20... gi\|254796382, gi... - gi\|254796382\|ref\|YP_003081219.1\| putative lipoate-protein ligase A [Escherichia coli O157:H7 str. TW... gi\|217320954, gi... - gi\|217324733\|ref\|ZP_03440817.1\| protein smp precursor [Escherichia coli O157:H7 str. TW14588], gi\|21... gi\|189405597, gi... - gi\|189405597\|ref\|ZP_02822967.2\| protein smp precursor [Escherichia coli O157:H7 str. EC508], gi\|1893... gi\|208807122, gi... - gi\|208807122\|ref\|ZP_03249459.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|208733311, gi... - gi\|208812034\|ref\|ZP_03253363.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4045], gi\|208... gi\|208739646, gi... - gi\|208819523\|ref\|ZP_03259843.1\| protein smp precursor [Escherichia coli O157:H7 str. EC4042], gi\|208... gi\|189356110, gi... - gi\|189402353\|ref\|ZP_02781813.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4401], gi\|189... gi\|189363979, gi... - gi\|189402794\|ref\|ZP_02791676.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4486], gi\|189... gi\|189367001, gi... - gi\|189404204\|ref\|ZP_02787747.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4501], gi\|189... gi\|189374913, gi... - gi\|189404619\|ref\|ZP_02810038.2\| protein smp precursor [Escherichia coli O157:H7 str. EC869], gi\|1893... gi\|187767992, gi... - gi\|187776280\|ref\|ZP_02801641.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4196], gi\|187... gi\|188025097, gi... - gi\|188025097\|ref\|ZP_02775997.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4113], gi\|188... gi\|189010377, gi... - gi\|189010377\|ref\|ZP_02806684.2\| protein smp precursor [Escherichia coli O157:H7 str. EC4076], gi\|189... gi\|15834599, gi\|... - gi\|15834599\|ref\|NP_313372.1\| unknown domain/lipoate-protein ligase A fusion protein [Escherichia col...	4.0E-71	[150..432]	[221..505]
EG11796 - lipoate-protein ligase A / Lipoate-protein ligase A; selenolipoate resistant LPLA_ECOLI - Lipoate-protein ligase A (EC 6.3.2.-) - Escherichia coli LPLA_ECOBW - Lipoate-protein ligase A OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=lplA PE=3 SV=1 EG11796 - lipoate-protein ligase A / Lipoate-protein ligase A; selenolipoate resistant LPLA_ECODH - Lipoate-protein ligase A OS=Escherichia coli (strain K12 / DH10B) GN=lplA PE=3 SV=1 gi\|89111094, gi\|... - gi\|89111094\|ref\|AP_004874.1\| lipoate-protein ligase A [Escherichia coli str. K-12 substr. W3110], gi...	3.0E-70	[154..432]	[1..281]
LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=lplA PE=... lcl\|NC_016856.1_... - [gene=lplA] [protein=lipoate-protein ligase A] [protein_id=YP_005240921.1] [location=complement(4844... gi\|197244278, gi... - gi\|197266023\|ref\|ZP_03166097.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium GN=lplA PE=3 SV=1 LPLA_SALTY - Lipoate-protein ligase A OS=Salmonella typhimurium GN=lplA PE=3 SV=1 gi\|167989818, gi... - gi\|205331409\|gb\|EDZ18173.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar 4,... gi\|205336596, gi... - gi\|205336596\|gb\|EDZ23360.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar He... LPLA_SALHS - Lipoate-protein ligase A OS=Salmonella heidelberg (strain SL476) GN=lplA PE=3 SV=1	3.0E-69	[154..431]	[1..280]
gi\|214000694 - gi\|214000694\|ref\|ZP_03411429.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213852198 - gi\|213852198\|ref\|ZP_03381730.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... LPLA_SALTI - Lipoate-protein ligase A OS=Salmonella typhi GN=lplA PE=3 SV=1 LPLA_SALTI - Lipoate-protein ligase A OS=Salmonella typhi GN=lplA PE=3 SV=1 gi\|16763367 - gi\|16763367\|ref\|NP_458984.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar T... gi\|213416956 - gi\|213416956\|ref\|ZP_03350100.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|29144845, gi\|... - gi\|29144845\|ref\|NP_808187.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serovar T... gi\|213051977 - gi\|213051977\|ref\|ZP_03344855.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213650710 - gi\|213650710\|ref\|ZP_03380763.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213612470 - gi\|213612470\|ref\|ZP_03370296.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213582043 - gi\|213582043\|ref\|ZP_03363869.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova... gi\|213427577 - gi\|213427577\|ref\|ZP_03360327.1\| lipoate-protein ligase A [Salmonella enterica subsp. enterica serova...	3.0E-69	[154..431]	[1..280]
gi\|269202641\|ref... - lipoate-protein ligase A family protein [Staphylococcus aureus subsp. aureus ED98] gi\|253316187 - gi\|253316187\|ref\|ZP_04839400.1\| lipoate-protein ligase-like protein [Staphylococcus aureus subsp. au... gi\|255005815 - gi\|255005815\|ref\|ZP_05144416.2\| lipoate-protein ligase-like protein [Staphylococcus aureus subsp. au... LPLA1_STAAM - Lipoate--protein ligase 1 OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=SAV1028 PE=1 SV=1 gi\|15926615, gi\|... - gi\|15926615\|ref\|NP_374148.1\| hypothetical protein SA0884 [Staphylococcus aureus subsp. aureus N315],... gi\|156721487, gi... - gi\|156979352\|ref\|YP_001441611.1\| lipoate-protein ligase-like protein [Staphylococcus aureus subsp. a... gi\|150393576, gi... - gi\|150393576\|ref\|YP_001316251.1\| lipoyltransferase and lipoate-protein ligase [Staphylococcus aureus... gi\|25293704 - pir\|\|C89871 hypothetical protein SA0884 [imported] - Staphylococcus aureus (strain N315) gi\|148267520, gi... - gi\|148267520\|ref\|YP_001246463.1\| lipoyltransferase and lipoate-protein ligase [Staphylococcus aureus...	1.0E-68	[159..438]	[3..282]
gi\|16800002 - gi\|16800002\|ref\|NP_470270.1\| hypothetical protein lin0931 [Listeria innocua Clip11262] gi\|16413379, gi\|... - pir\|\|AC1549 lipoate protein ligase A homolog lin0931 [imported] - Listeria innocua (strain Clip11262...	2.0E-68	[159..439]	[3..286]
gi\|225854635, gi... - gi\|225854635\|ref\|YP_002736147.1\| lipoate protein ligase A [Streptococcus pneumoniae JJA], gi\|2257232... gi\|25293702 - pir\|\|D95134 lipoate-protein ligase, probable [imported] - Streptococcus pneumoniae (strain TIGR4) gi\|66879185, gi\|... - gi\|66879185\|ref\|ZP_00404213.1\| COG0095: Lipoate-protein ligase A [Streptococcus pneumoniae TIGR4], g...	4.0E-68	[161..439]	[4..283]
gi\|168483222, gi... - gi\|172043498\|gb\|EDT51544.1\| lipoate protein ligase A [Streptococcus pneumoniae CDC1873-00], gi\|16848... gi\|25293705 - pir\|\|G98002 lipoate protein ligase A (EC 6.-.-.-) [imported] - Streptococcus pneumoniae (strain R6) gi\|15458668, gi\|... - gi\|15903091\|ref\|NP_358641.1\| lipoate-protein ligase, putative [Streptococcus pneumoniae R6], gi\|1545... gi\|116077327, gi... - gi\|116516751\|ref\|YP_816498.1\| lipoate-protein ligase, putative [Streptococcus pneumoniae D39], gi\|11... gi\|148985768, gi... - gi\|148985768\|ref\|ZP_01818896.1\| lipoate-protein ligase, putative [Streptococcus pneumoniae SP3-BS71]... gi\|225725441, gi... - gi\|225856837\|ref\|YP_002738348.1\| lipoate protein ligase A [Streptococcus pneumoniae P1031], gi\|22572...	6.0E-68	[161..439]	[4..283]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSASSYLIR NIEHPKISEL TYVEFLMNTK EENTRLFFDV YIMSMMLSNW ALSPRYVGQR  60
   61 NLIHCTTLFH TLTRWAKDAD DKYHDINSMY ENMFTPSNDN VSILQDEGKS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.593	a.4.12	TrpR-like
View	Download	0.593	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.593	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.567	a.4.12	TrpR-like
View	Download	0.567	a.4.12	TrpR-like
View	Download	0.525	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.525	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.477	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.477	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.466	d.58.26	GHMP Kinase, C-terminal domain
View	Download	0.446	a.24.17	Group V grass pollen allergen
View	Download	0.389	a.74.1	Cyclin-like
View	Download	0.370	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.361	a.75.1	Ribosomal protein S7
View	Download	0.343	d.95.2	Homing endonucleases
View	Download	0.340	a.118.8	TPR-like
View	Download	0.337	a.24.16	Nucleotidyltransferase substrate binding subunit/domain
View	Download	0.336	a.77.1	DEATH domain
View	Download	0.322	a.7.7	BAG domain
View	Download	0.315	a.61.1	Retroviral matrix proteins
View	Download	0.315	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.308	a.85.1	Hemocyanin, N-terminal domain
View	Download	0.301	a.7.3	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View	Download	0.292	f.14.1	Voltage-gated potassium channels
View	Download	0.291	e.37.1	Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View	Download	0.291	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.284	a.1.1	Globin-like
View	Download	0.283	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.282	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.265	a.118.8	TPR-like
View	Download	0.264	a.24.9	alpha-catenin/vinculin
View	Download	0.261	a.28.1	ACP-like
View	Download	0.260	a.29.2	Bromodomain
View	Download	0.239	a.26.1	4-helical cytokines
View	Download	0.237	a.118.1	ARM repeat
View	Download	0.235	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.235	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.232	a.118.1	ARM repeat
View	Download	0.230	c.55.6	DNA repair protein MutS, domain II
View	Download	0.229	a.74.1	Cyclin-like
View	Download	0.226	a.46.1	Methionine synthase domain
View	Download	0.225	a.24.4	Hemerythrin
View	Download	0.224	a.7.8	GAT domain
View	Download	0.222	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.213	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.212	a.41.1	Domain of poly(ADP-ribose) polymerase
View	Download	0.209	a.2.3	Chaperone J-domain
View	Download	0.208	a.11.1	Acyl-CoA binding protein
View	Download	0.204	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.203	a.57.1	Protein HNS-dependent expression A; HdeA

Predicted Domain #2

Region A:
Residues: [111-228]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYDTTKASSM EEDISAFNKD LYNFYNIGYA KQIMSASQLE NIVKAKGRFV IQSLSTSPYY  60
   61 NLALENYVFK NTPRAKRGPD NCRLLFYIND RCAVIGKNQN LWQEVDLAKL KSKNFELL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.445	N/A	N/A	d.109.1	Actin depolymerizing proteins
View	Download	0.404	N/A	N/A	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.378	N/A	N/A	d.58.43	Mechanosensitive channel protein MscS (YggB), C-terminal domain
View	Download	0.311	N/A	N/A	d.109.1	Actin depolymerizing proteins
View	Download	0.251	N/A	N/A	d.129.4	Cell-division protein ZipA, C-terminal domain
View	Download	0.239	N/A	N/A	d.206.1	YggU-like
View	Download	0.232	N/A	N/A	d.21.1	Diaminopimelate epimerase-like
View	Download	0.228	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.208	N/A	N/A	d.82.2	Frataxin-like

Predicted functions:

Term	Confidence	Notes
aminoacyl-tRNA ligase activity	4.11741584670871	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	4.11627822082383	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	4.11627822082383	bayes_pls_golite062009
ligase activity	2.91948094816945	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	0.729947203019949	bayes_pls_golite062009
threonine-tRNA ligase activity	0.240788175151445	bayes_pls_golite062009
serine-tRNA ligase activity	0.228481182681194	bayes_pls_golite062009
glycine-tRNA ligase activity	0.150020288395523	bayes_pls_golite062009
binding	0.0498327097792011	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [229-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRFSGGGTVL HDLGNVNYSY LTSREKFETK FFNKMIIKWL NSLNPELRLD LNERGDIIQD  60
   61 GFKISGSAYK IAGGKAYHHA TMLLNADLEQ FSGLLEPSLP NNMEWESSGV HSVKSKIKNV 120
  121 GIITPNQFIA VVSERFQKTF KVDGEIPIYY CDEFKSINDE IKDAMNTLQS EQWKYFSGPK 180
  181 FSVKIKDKGL TIKVEKGMIY DCDRNDLIGL EFKGFLENID SYT

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.24
Match:	1hxdA
Description:	Biotin repressor, N-terminal domain; Biotin repressor/biotin holoenzyme synthetase, C-terminal domain; Biotin repressor/biotin holoenzyme synthetase, catalytic (central) domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: