YRC Public Data Repository - Protein Structure Prediction

Protein:	DJP1
Organism:	Saccharomyces cerevisiae
Length:	432 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DJP1.

Description	E-value	Query Range	Subject Range
DJP1_YEAST - DnaJ-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DJP1 PE=1 SV=1 DJP1 - Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in perox... gi\|190406219 - gi\|190406219\|gb\|EDV09486.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	5.0E-95	[1..432]	[1..432]
DNAJ_RHILO - Chaperone protein dnaJ OS=Rhizobium loti GN=dnaJ PE=3 SV=1 DNAJ_RHILO - Chaperone protein DnaJ OS=Rhizobium loti (strain MAFF303099) GN=dnaJ PE=3 SV=1	3.0E-87	[3..362]	[1..355]
DNAJ_AGRFC - Chaperone protein DnaJ OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=dnaJ PE=2 SV=2 gi\|25296037, gi\|... - pir\|\|AD2591 molecular chaperone, DnaJ family dnaJ [imported] - Agrobacterium tumefaciens (strain C58...	7.0E-87	[2..362]	[1..360]
DNAJ_BRUOV - Chaperone protein dnaJ - Brucella ovis	2.0E-85	[3..362]	[1..355]
DNAJ_RHIME - Chaperone protein DnaJ OS=Rhizobium meliloti (strain 1021) GN=dnaJ PE=3 SV=1 DNAJ_RHIME - Chaperone protein dnaJ OS=Rhizobium meliloti GN=dnaJ PE=3 SV=1	4.0E-83	[3..362]	[1..359]
gi\|107103857 - gi\|107103857\|ref\|ZP_01367775.1\| hypothetical protein PaerPA_01004928 [Pseudomonas aeruginosa PACS2] DNAJ_PSEA8 - Chaperone protein DnaJ OS=Pseudomonas aeruginosa (strain LESB58) GN=dnaJ PE=3 SV=1 DNAJ_PSEAE - Chaperone protein dnaJ OS=Pseudomonas aeruginosa GN=dnaJ PE=3 SV=1 DNAJ_PSEAB - Chaperone protein DnaJ OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=dnaJ PE=3 SV=1 DNAJ_PSEAE - Chaperone protein DnaJ OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 1222... gi\|194549490, gi... - gi\|84317360\|ref\|ZP_00965808.1\| COG0484: DnaJ-class molecular chaperone with C-terminal Zn finger dom... gi\|126197717, gi... - gi\|84323584\|ref\|ZP_00971653.1\| COG0484: DnaJ-class molecular chaperone with C-terminal Zn finger dom...	5.0E-82	[2..358]	[1..353]
gi\|89106899, gi\|... - gi\|89106899\|ref\|AP_000679.1\| chaperone Hsp40, co-chaperone with DnaK [Escherichia coli str. K-12 sub... DNAJ_ECODH - Chaperone protein DnaJ OS=Escherichia coli (strain K12 / DH10B) GN=dnaJ PE=3 SV=1 DNAJ_ECOLI - Chaperone protein dnaJ (Heat shock protein J) (HSP40) - Escherichia coli EG10240 - chaperone Hsp40, DnaK co-chaperone / DnaK co-chaperone HSP40; DNA-binding protein; stress-related DN... EG10240 - chaperone Hsp40, DnaK co-chaperone / DnaK co-chaperone HSP40; DNA-binding protein; stress-related DN...	2.0E-81	[2..357]	[1..347]
DNAJ_BRUSU - Chaperone protein DnaJ OS=Brucella suis biovar 1 (strain 1330) GN=dnaJ PE=3 SV=1 DNAJ_BRUME - Chaperone protein DnaJ OS=Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) GN=dn... DNAJ_BRUMB - Chaperone protein DnaJ OS=Brucella melitensis biotype 2 (strain ATCC 23457) GN=dnaJ PE=3 SV=1 gi\|225618155, gi... - gi\|225626498\|ref\|ZP_03784537.1\| chaperone protein DnaJ [Brucella ceti str. Cudo], gi\|225618155\|gb\|EE... gi\|254705131 - gi\|254705131\|ref\|ZP_05166959.1\| chaperone protein DnaJ [Brucella suis bv. 3 str. 686] DNAJ_BRUSU - Chaperone protein dnaJ OS=Brucella suis GN=dnaJ PE=3 SV=1 gi\|254700759 - gi\|254700759\|ref\|ZP_05162587.1\| chaperone protein DnaJ [Brucella suis bv. 5 str. 513] gi\|254709104 - gi\|254709104\|ref\|ZP_05170915.1\| chaperone protein DnaJ [Brucella pinnipedialis B2/94] DNAJ_BRUME - Chaperone protein dnaJ OS=Brucella melitensis GN=dnaJ PE=3 SV=1 gi\|254707354 - gi\|254707354\|ref\|ZP_05169182.1\| chaperone protein DnaJ [Brucella pinnipedialis M163/99/10] gi\|254718169 - gi\|254718169\|ref\|ZP_05179980.1\| chaperone protein DnaJ [Brucella sp. 83/13] DNAJ_BRUSI - Chaperone protein DnaJ OS=Brucella suis (strain ATCC 23445 / NCTC 10510) GN=dnaJ PE=3 SV=1 DNAJ_BRUC2 - Chaperone protein DnaJ OS=Brucella canis (strain ATCC 23365 / NCTC 10854) GN=dnaJ PE=3 SV=1	2.0E-81	[3..362]	[1..357]
DNAJ_RALSO - Chaperone protein dnaJ OS=Ralstonia solanacearum GN=dnaJ PE=3 SV=1 DNAJ_RALSO - Chaperone protein DnaJ OS=Ralstonia solanacearum (strain GMI1000) GN=dnaJ PE=3 SV=1	3.0E-81	[2..357]	[1..355]

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Predicted Domain #1

Region A:
Residues: [1-117]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVDTEYYDL LGVSTTASSI EIKKAYRKKS IQEHPDKNPN DPTATERFQA ISEAYQVLGD  60
   61 DDLRAKYDKY GRKEAIPQGG FEDAAEQFSV IFGGDAFASY IGELMLLKNL QKTEELN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	143.70927
Match:	1xbl__
Description:	DnaJ chaperone, N-terminal (J) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	3.04403163860617	bayes_pls_golite062009
binding	2.4835091517649	bayes_pls_golite062009
heat shock protein binding	2.17994194200939	bayes_pls_golite062009
protein binding	1.81676109739118	bayes_pls_golite062009
chaperone binding	1.61155546076854	bayes_pls_golite062009
Hsp70 protein binding	0.541755903922701	bayes_pls_golite062009
nucleic acid binding	0.423488346839872	bayes_pls_golite062009
transcription regulator activity	0.146399219759372	bayes_pls_golite062009
catalytic activity	0.106988907594358	bayes_pls_golite062009
DNA binding	0.10307408349439	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [118-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEDEAEKEKE NVETMEESPA DGKTNGTTNA VDAALGNTNE KDDKNKARTT SGNLTVHDGN  60
   61 KKNEQVGAEA KKKKTKLEQF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.69897
Match:	1exkA_
Description:	Cysteine-rich domain of the chaperone protein DnaJ.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.58201259799527	bayes_pls_golite062009
unfolded protein binding	2.04158808514315	bayes_pls_golite062009
protein binding	1.7866515791227	bayes_pls_golite062009
protein disulfide isomerase activity	0.290861970307477	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	0.290861970307477	bayes_pls_golite062009
catalytic activity	0.276917867171685	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	0.0964866497718595	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [198-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEQEVEKQK RVDQLSKTLI ERLSILTESV YDDACKDSFK KKFEEEANLL KMESFGLDIL  60
   61 HTIGDVYYEK AEIFLASQNL FGMGGIFHSM KAKGGVFMDT LRTVSAAIDA QNTMKELEKM 120
  121 KEASTNNE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.045757
Match:	1c3gA_
Description:	Heat shock protein 40 Sis1
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [326-432]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLFDKDGNEQ IKPTTEELAQ QEQLLMGKVL SAAWHGSKYE ITSTLRGVCK KVLEDDSVSK  60
   61 KTLIRRAEAM KLLGEVFKKT FRTKVEQEEA QIFEELVAEA TKKKRHT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.940	0.607	cytosol	a.118.9	ENTH/VHS domain
View	Download	0.936	0.001	cytosol	a.24.4	Hemerythrin
View	Download	0.978	0.001	cytosol	a.24.17	Group V grass pollen allergen
View	Download	0.940	0.000	cytosol	a.46.1	Methionine synthase domain
View	Download	0.927	N/A	N/A	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.879	N/A	N/A	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.848	N/A	N/A	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.846	N/A	N/A	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.833	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.814	N/A	N/A	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.806	N/A	N/A	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.799	N/A	N/A	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.779	N/A	N/A	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.772	N/A	N/A	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.766	N/A	N/A	a.118.8	TPR-like
View	Download	0.749	N/A	N/A	a.29.4	RecG, N-terminal domain
View	Download	0.747	N/A	N/A	a.118.1	ARM repeat
View	Download	0.669	N/A	N/A	a.7.7	BAG domain
View	Download	0.658	N/A	N/A	a.71.2	Helical domain of Sec23/24
View	Download	0.645	N/A	N/A	a.24.3	Cytochromes
View	Download	0.627	N/A	N/A	a.7.3	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View	Download	0.625	N/A	N/A	d.54.1	Enolase N-terminal domain-like
View	Download	0.621	N/A	N/A	a.24.15	FAD-dependent thiol oxidase
View	Download	0.614	N/A	N/A	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.583	N/A	N/A	a.24.15	FAD-dependent thiol oxidase
View	Download	0.577	N/A	N/A	a.7.6	Ribosomal protein S20
View	Download	0.566	N/A	N/A	d.95.2	Homing endonucleases
View	Download	0.553	N/A	N/A	e.20.1	Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View	Download	0.545	N/A	N/A	a.118.8	TPR-like
View	Download	0.543	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.532	N/A	N/A	a.26.1	4-helical cytokines
View	Download	0.528	N/A	N/A	a.2.3	Chaperone J-domain
View	Download	0.526	N/A	N/A	a.26.1	4-helical cytokines
View	Download	0.515	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.511	N/A	N/A	a.24.3	Cytochromes
View	Download	0.503	N/A	N/A	i.11.1	Computational models partly based on NMR data
View	Download	0.496	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.471	N/A	N/A	d.95.2	Homing endonucleases
View	Download	0.462	N/A	N/A	a.133.1	Phospholipase A2, PLA2
View	Download	0.456	N/A	N/A	a.7.3	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View	Download	0.456	N/A	N/A	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.443	N/A	N/A	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.439	N/A	N/A	d.54.1	Enolase N-terminal domain-like
View	Download	0.438	N/A	N/A	a.90.1	Transcription factor STAT-4 N-domain
View	Download	0.437	N/A	N/A	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.434	N/A	N/A	a.24.14	FAT domain of focal adhesion kinase
View	Download	0.429	N/A	N/A	a.24.16	Nucleotidyltransferase substrate binding subunit/domain
View	Download	0.424	N/A	N/A	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.423	N/A	N/A	a.64.1	Saposin
View	Download	0.423	N/A	N/A	a.24.3	Cytochromes
View	Download	0.422	N/A	N/A	a.7.8	GAT domain
View	Download	0.420	N/A	N/A	d.58.39	Glutamyl tRNA-reductase catalytic, N-terminal domain
View	Download	0.420	N/A	N/A	d.79.2	Tubulin/Dihydroxyacetone kinase C-terminal domain
View	Download	0.420	N/A	N/A	a.64.1	Saposin
View	Download	0.419	N/A	N/A	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.416	N/A	N/A	a.24.11	Bacterial GAP domain
View	Download	0.410	N/A	N/A	a.29.2	Bromodomain
View	Download	0.406	N/A	N/A	a.1.1	Globin-like
View	Download	0.402	N/A	N/A	a.29.2	Bromodomain
View	Download	0.400	N/A	N/A	d.58.26	GHMP Kinase, C-terminal domain
View	Download	0.400	N/A	N/A	a.24.3	Cytochromes
View	Download	0.396	N/A	N/A	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.386	N/A	N/A	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.383	N/A	N/A	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.382	N/A	N/A	a.60.10	Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View	Download	0.381	N/A	N/A	a.24.11	Bacterial GAP domain
View	Download	0.379	N/A	N/A	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.370	N/A	N/A	a.25.2	Thermoplasma ferritin-like 4-helical bundle
View	Download	0.367	N/A	N/A	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.362	N/A	N/A	a.24.3	Cytochromes
View	Download	0.356	N/A	N/A	a.61.1	Retroviral matrix proteins
View	Download	0.356	N/A	N/A	a.26.1	4-helical cytokines
View	Download	0.354	N/A	N/A	a.78.1	Fatty acid responsive transcription factor FadR, C-terminal domain
View	Download	0.353	N/A	N/A	a.64.1	Saposin
View	Download	0.352	N/A	N/A	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.348	N/A	N/A	d.58.26	GHMP Kinase, C-terminal domain
View	Download	0.342	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.339	N/A	N/A	a.118.9	ENTH/VHS domain
View	Download	0.338	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.334	N/A	N/A	a.151.1	Glutamyl tRNA-reductase dimerization domain
View	Download	0.334	N/A	N/A	a.64.1	Saposin
View	Download	0.329	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.328	N/A	N/A	a.23.5	Hemolysin expression modulating protein HHA
View	Download	0.324	N/A	N/A	a.11.1	Acyl-CoA binding protein
View	Download	0.321	N/A	N/A	a.61.1	Retroviral matrix proteins
View	Download	0.318	N/A	N/A	a.131.1	Peridinin-chlorophyll protein
View	Download	0.307	N/A	N/A	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.307	N/A	N/A	f.34.1	Mechanosensitive channel protein MscS (YggB), transmembrane region
View	Download	0.305	N/A	N/A	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.302	N/A	N/A	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.298	N/A	N/A	a.118.1	ARM repeat
View	Download	0.297	N/A	N/A	a.146.1	Telomeric repeat binding factor (TRF) dimerisation domain
View	Download	0.296	N/A	N/A	a.64.1	Saposin
View	Download	0.296	N/A	N/A	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.296	N/A	N/A	a.69.3	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View	Download	0.291	N/A	N/A	a.47.2	t-snare proteins
View	Download	0.290	N/A	N/A	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.288	N/A	N/A	a.4.1	Homeodomain-like
View	Download	0.283	N/A	N/A	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.279	N/A	N/A	a.1.1	Globin-like
View	Download	0.278	N/A	N/A	a.1.1	Globin-like
View	Download	0.278	N/A	N/A	a.8.2	Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View	Download	0.277	N/A	N/A	a.159.1	Protein serine/threonine phosphatase 2C, C-terminal domain
View	Download	0.276	N/A	N/A	a.7.3	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View	Download	0.275	N/A	N/A	d.8.1	Urease, gamma-subunit
View	Download	0.273	N/A	N/A	a.118.16	Testis/brain RNA-binding protein (TB-RBP)
View	Download	0.270	N/A	N/A	a.39.1	EF-hand
View	Download	0.267	N/A	N/A	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.266	N/A	N/A	a.126.1	Serum albumin-like
View	Download	0.265	N/A	N/A	a.2.3	Chaperone J-domain
View	Download	0.263	N/A	N/A	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.262	N/A	N/A	d.204.1	Ribosome binding protein Y (YfiA homologue)
View	Download	0.258	N/A	N/A	a.8.3	Families 57/38 glycoside transferase middle domain
View	Download	0.255	N/A	N/A	a.39.1	EF-hand
View	Download	0.254	N/A	N/A	f.1.3	delta-Endotoxin (insectocide), N-terminal domain
View	Download	0.254	N/A	N/A	d.163.1	DNA breaking-rejoining enzymes
View	Download	0.252	N/A	N/A	a.118.12	Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View	Download	0.249	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.244	N/A	N/A	a.65.1	Annexin
View	Download	0.238	N/A	N/A	c.45.1	(Phosphotyrosine protein) phosphatases II
View	Download	0.235	N/A	N/A	a.26.1	4-helical cytokines
View	Download	0.235	N/A	N/A	a.60.1	SAM/Pointed domain
View	Download	0.235	N/A	N/A	a.39.3	Cloroperoxidase
View	Download	0.231	N/A	N/A	a.7.1	Spectrin repeat
View	Download	0.229	N/A	N/A	c.8.5	GroEL apical domain-like
View	Download	0.228	N/A	N/A	d.41.2	Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain
View	Download	0.228	N/A	N/A	a.13.1	alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View	Download	0.226	N/A	N/A	a.7.1	Spectrin repeat
View	Download	0.223	N/A	N/A	a.1.1	Globin-like
View	Download	0.223	N/A	N/A	a.26.1	4-helical cytokines
View	Download	0.219	N/A	N/A	a.19.1	Fertilization protein
View	Download	0.213	N/A	N/A	a.101.1	Uteroglobin-like
View	Download	0.212	N/A	N/A	a.177.1	Sigma2 domain of RNA polymerase sigma factors
View	Download	0.212	N/A	N/A	d.192.1	YlxR-like
View	Download	0.208	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.204	N/A	N/A	a.112.1	Description not found.
View	Download	0.202	N/A	N/A	a.51.1	Cytochrome c oxidase subunit h
View	Download	0.201	N/A	N/A	a.2.3	Chaperone J-domain
View	Download	0.201	N/A	N/A	a.87.1	DBL homology domain (DH-domain)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: