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View Structure Prediction Details

Protein: GVP36
Organism: Saccharomyces cerevisiae
Length: 326 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GVP36.

Description E-value Query
Range
Subject
Range
gi|151943118 - gi|151943118|gb|EDN61453.1| Golgi vesicle protein [Saccharomyces cerevisiae YJM789]
GVP36 - BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for ada...
gi|207344298 - gi|207344298|gb|EDZ71488.1| YIL041Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GVP36_YEAST - Protein GVP36 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GVP36 PE=1 SV=1
gi|190406261 - gi|190406261|gb|EDV09528.1| peripheral membrane protein [Saccharomyces cerevisiae RM11-1a]
3.0E-72 [1..326] [1..326]
gi|60822960, gi|... - gi|60822960|gb|AAX36627.1| SH3-domain GRB2-like 1 [synthetic construct], gi|123980710|gb|ABM82184.1|...
SH3GL1 - SH3-domain GRB2-like 1
1.0E-65 [32..317] [10..260]
SH3G1_MOUSE - Endophilin-A2 OS=Mus musculus GN=Sh3gl1 PE=1 SV=1
gi|55250502 - gb|AAH86079.1| Unknown (protein for MGC:98448) [Xenopus laevis]
5.0E-65 [32..317] [10..260]
SH3G1_RAT - Endophilin-A2 OS=Rattus norvegicus GN=Sh3gl1 PE=1 SV=1
2.0E-64 [32..317] [10..260]
gi|11761988 - gi|11761988|gb|AAG40277.1|AF304353_1 endophilin SH3p4 [Lampetra fluviatilis]
7.0E-61 [32..322] [10..267]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFNAFASSL SKKLQEISTS VSEKTQELPS LAQSTQRMVQ ERLGQVTDIS QLPREYTELE  60
   61 DKVDTIKLIY NHFLGVTAIY ENGSYDYPKY INESVNEFSR SVASKLTELT HAT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.757 a.24.9 alpha-catenin/vinculin
View Download 0.543 a.74.1 Cyclin-like
View Download 0.430 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.469 d.129.4 Cell-division protein ZipA, C-terminal domain
View Download 0.479 a.26.1 4-helical cytokines
View Download 0.375 a.24.11 Bacterial GAP domain
View Download 0.358 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.338 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.321 a.7.8 GAT domain
View Download 0.310 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.304 a.25.1 Ferritin-like
View Download 0.300 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.275 a.7.7 BAG domain
View Download 0.266 a.26.1 4-helical cytokines
View Download 0.263 a.71.2 Helical domain of Sec23/24
View Download 0.254 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.246 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.241 a.7.1 Spectrin repeat
View Download 0.237 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.234 a.71.2 Helical domain of Sec23/24
View Download 0.233 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.232 a.7.1 Spectrin repeat
View Download 0.227 c.55.1 Actin-like ATPase domain
View Download 0.222 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.222 d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.216 d.79.3 L30e-like
View Download 0.215 a.1.1 Globin-like
View Download 0.212 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.211 a.47.2 t-snare proteins
View Download 0.209 a.131.1 Peridinin-chlorophyll protein
View Download 0.209 d.198.2 Arp2/3 complex subunits
View Download 0.201 d.58.41 SEA domain
View Download 0.201 d.198.1 Type III secretory system chaperone
View Download 0.201 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.200 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.200 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.200 d.41.2 Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain

Predicted functions:

Term Confidence Notes
binding 2.2879693624429 bayes_pls_golite062009
protein binding 2.08046860800611 bayes_pls_golite062009
cytoskeletal protein binding 1.02414077739262 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.067852352497379 bayes_pls_golite062009
pyrophosphatase activity 0.0314833132263769 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0230779033512197 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0199119414909105 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASEAQNILV APGPIKEPKT LNYALSKVAL NSSECLNKMF PTEEQPLASA LLQFSDVQAK  60
   61 IAQARIQQDT LIQTKFNKNL RERLSFEIGK ADKCRKDVHS MRLRYDVART NLANNKKPEK 120
  121 EASLRVQMET LEDQFAQVTE DATVCLQEVI SHANFSEDLK ELAKAQAEYF ETSAGLMKEF 180
  181 LSNSFAEEPE AKPEVAEEEK PQTAISMNDE DDA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.91
Match: 1i49A
Description: Arfaptin, Rac-binding fragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle