YRC Public Data Repository - Protein Structure Prediction

Protein:	DCD1
Organism:	Saccharomyces cerevisiae
Length:	312 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCD1.

Description	E-value	Query Range	Subject Range
DCD1 - Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT... gi\|151944091 - gi\|151944091\|gb\|EDN62384.1\| dCMP deaminase [Saccharomyces cerevisiae YJM789] DCTD_YEAST - Deoxycytidylate deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCD1 PE=1 SV=2	0.0	[1..312]	[1..312]
SPBC2G2.13c - deoxycytidylate deaminase DCTD_SCHPO - Deoxycytidylate deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC2G2.13c PE=2...	2.0E-75	[32..305]	[51..344]
gi\|15643170, gi\|... - gi\|4980909\|gb\|AAD35489.1\|AE001720_3 deoxycytidylate deaminase, putative [Thermotoga maritima MSB8], ... gi\|7448897 - pir\|\|B72380 hypothetical protein TM0404 - Thermotoga maritima (strain MSB8)	2.0E-45	[112..305]	[6..200]
gi\|25290264 - pir\|\|F83816 late competence operon required for DNA binding and uptake comEB [imported] - Bacillus h... gi\|15613897, gi\|... - gi\|15613897\|ref\|NP_242200.1\| late competence operon required for DNA binding and uptake [Bacillus ha...	4.0E-41	[158..305]	[1..143]
gi\|14325550, gi\|... - gi\|14325550\|dbj\|BAB60453.1\| dCMP deaminase [Thermoplasma volcanium GSS1], gi\|13542119\|ref\|NP_111807....	2.0E-39	[155..312]	[1..160]
gi\|52786486, gi\|... - gi\|52786486\|ref\|YP_092315.1\| hypothetical protein BLi02751 [Bacillus licheniformis ATCC 14580], gi\|5... gi\|18266365 - gi\|18266365\|gb\|AAL67525.1\|AF459916_2 late competence protein ComEB [Bacillus licheniformis]	3.0E-39	[158..305]	[1..143]
gi\|13701387, gi\|... - gi\|15927169\|ref\|NP_374702.1\| late competence operon required for DNA binding and uptake comEB [Staph... gi\|49486423, gi\|... - gi\|49486423\|ref\|YP_043644.1\| putative deaminase [Staphylococcus aureus subsp. aureus MSSA476], gi\|49... gi\|15924579, gi\|... - gi\|15924579\|ref\|NP_372113.1\| late competence operon required for DNA binding and uptake [Staphylococ... gi\|255006374 - gi\|255006374\|ref\|ZP_05144975.2\| competence protein ComEB [Staphylococcus aureus subsp. aureus Mu50-o... gi\|25320356 - pir\|\|D89940 hypothetical protein comEB [imported] - Staphylococcus aureus (strain N315) gi\|21283269, gi\|... - gi\|21283269\|ref\|NP_646357.1\| late competence operon required for DNA binding and uptake comEB [Staph... gi\|82751191, gi\|... - gi\|82751191\|ref\|YP_416932.1\| late competence deaminase protein [Staphylococcus aureus RF122], gi\|826... gi\|156979907, gi... - gi\|156979907\|ref\|YP_001442166.1\| late competence operon required for DNA binding and uptake [Staphyl... gi\|151221703, gi... - gi\|151221703\|ref\|YP_001332525.1\| competence protein ComEB required for DNA binding and uptake [Staph...	7.0E-39	[158..306]	[1..144]
gi\|7448896 - pir\|\|C69470 dCMP deaminase homolog - Archaeoglobus fulgidus gi\|2648787, gi\|1... - gi\|2648787\|gb\|AAB89487.1\| dCMP deaminase, putative [Archaeoglobus fulgidus DSM 4304], gi\|11499353\|re...	8.0E-39	[158..310]	[1..155]
gi\|16081448 - gi\|16081448\|ref\|NP_393792.1\| dCMP deaminase [Thermoplasma acidophilum DSM 1728] gi\|10639455 - gi\|10639455\|emb\|CAC11457.1\| probable dCMP deaminase [Thermoplasma acidophilum]	1.0E-38	[155..312]	[1..160]

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Predicted Domain #1

Region A:
Residues: [1-111]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIGVSGTKF CGCEDVINML VDHFHFELLN HLDNPEEILD YATKNYTKNS VIFLEKLSLL  60
   61 EKLEKRPFFV HLSIDAPVTT RVALYRKTTQ AESLSLEQII QAIDQHDFQP E

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.71761116975383	bayes_pls_golite062009
catalytic activity	0.942640875796745	bayes_pls_golite062009
hydrolase activity	0.799258945993812	bayes_pls_golite062009
protein binding	0.262528335081572	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.205823354338506	bayes_pls_golite062009
nucleic acid binding	0.18803512517078	bayes_pls_golite062009
purine nucleotide binding	0.144773327806905	bayes_pls_golite062009
nucleotide binding	0.140809536790465	bayes_pls_golite062009
purine ribonucleotide binding	0.134373265505829	bayes_pls_golite062009
ribonucleotide binding	0.134362467171752	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [112-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIKLREKSHL RFKIVNEDRR GRRQSLINNI TTQLKILDDK EKQMAPLMRP SWDSYFMKLA  60
   61 TLAASRSNCM KRRVGCVIVR ECRVIATGYN GTPRHLTNCF NGGCPRCNDG DSRNLHTCLC 120
  121 LHAEENALLE AGRDRVGQNA TLYCDTCPCL TCSVKIVQTG ISEVVYSQSY RMDEESFKVL 180
  181 KNAGITVRQF SFTEEPRIVM I

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.99
Match:	1jtkA
Description:	mono-domain cytidine deaminase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: