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View Structure Prediction Details

Protein: DCD1
Organism: Saccharomyces cerevisiae
Length: 312 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCD1.

Description E-value Query
Range
Subject
Range
DCD1 - Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT...
gi|151944091 - gi|151944091|gb|EDN62384.1| dCMP deaminase [Saccharomyces cerevisiae YJM789]
DCTD_YEAST - Deoxycytidylate deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCD1 PE=1 SV=2
0.0 [1..312] [1..312]
SPBC2G2.13c - deoxycytidylate deaminase
DCTD_SCHPO - Deoxycytidylate deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC2G2.13c PE=2...
2.0E-75 [32..305] [51..344]
gi|15643170, gi|... - gi|4980909|gb|AAD35489.1|AE001720_3 deoxycytidylate deaminase, putative [Thermotoga maritima MSB8], ...
gi|7448897 - pir||B72380 hypothetical protein TM0404 - Thermotoga maritima (strain MSB8)
2.0E-45 [112..305] [6..200]
gi|25290264 - pir||F83816 late competence operon required for DNA binding and uptake comEB [imported] - Bacillus h...
gi|15613897, gi|... - gi|15613897|ref|NP_242200.1| late competence operon required for DNA binding and uptake [Bacillus ha...
4.0E-41 [158..305] [1..143]
gi|14325550, gi|... - gi|14325550|dbj|BAB60453.1| dCMP deaminase [Thermoplasma volcanium GSS1], gi|13542119|ref|NP_111807....
2.0E-39 [155..312] [1..160]
gi|52786486, gi|... - gi|52786486|ref|YP_092315.1| hypothetical protein BLi02751 [Bacillus licheniformis ATCC 14580], gi|5...
gi|18266365 - gi|18266365|gb|AAL67525.1|AF459916_2 late competence protein ComEB [Bacillus licheniformis]
3.0E-39 [158..305] [1..143]
gi|13701387, gi|... - gi|15927169|ref|NP_374702.1| late competence operon required for DNA binding and uptake comEB [Staph...
gi|49486423, gi|... - gi|49486423|ref|YP_043644.1| putative deaminase [Staphylococcus aureus subsp. aureus MSSA476], gi|49...
gi|15924579, gi|... - gi|15924579|ref|NP_372113.1| late competence operon required for DNA binding and uptake [Staphylococ...
gi|255006374 - gi|255006374|ref|ZP_05144975.2| competence protein ComEB [Staphylococcus aureus subsp. aureus Mu50-o...
gi|25320356 - pir||D89940 hypothetical protein comEB [imported] - Staphylococcus aureus (strain N315)
gi|21283269, gi|... - gi|21283269|ref|NP_646357.1| late competence operon required for DNA binding and uptake comEB [Staph...
gi|82751191, gi|... - gi|82751191|ref|YP_416932.1| late competence deaminase protein [Staphylococcus aureus RF122], gi|826...
gi|156979907, gi... - gi|156979907|ref|YP_001442166.1| late competence operon required for DNA binding and uptake [Staphyl...
gi|151221703, gi... - gi|151221703|ref|YP_001332525.1| competence protein ComEB required for DNA binding and uptake [Staph...
7.0E-39 [158..306] [1..144]
gi|7448896 - pir||C69470 dCMP deaminase homolog - Archaeoglobus fulgidus
gi|2648787, gi|1... - gi|2648787|gb|AAB89487.1| dCMP deaminase, putative [Archaeoglobus fulgidus DSM 4304], gi|11499353|re...
8.0E-39 [158..310] [1..155]
gi|16081448 - gi|16081448|ref|NP_393792.1| dCMP deaminase [Thermoplasma acidophilum DSM 1728]
gi|10639455 - gi|10639455|emb|CAC11457.1| probable dCMP deaminase [Thermoplasma acidophilum]
1.0E-38 [155..312] [1..160]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIGVSGTKF CGCEDVINML VDHFHFELLN HLDNPEEILD YATKNYTKNS VIFLEKLSLL  60
   61 EKLEKRPFFV HLSIDAPVTT RVALYRKTTQ AESLSLEQII QAIDQHDFQP E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.793 c.23.1 CheY-like
View Download 0.723 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.657 c.57.1 Molybdenum cofactor biosynthesis proteins
View Download 0.657 c.51.3 B12-dependend dehydatases associated subunit
View Download 0.663 c.23.1 CheY-like
View Download 0.626 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.617 c.53.1 Resolvase-like
View Download 0.602 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.577 c.23.1 CheY-like
View Download 0.555 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.544 c.78.2 Aspartate/glutamate racemase
View Download 0.535 c.23.16 Class I glutamine amidotransferase-like
View Download 0.535 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.526 c.44.2 Enzyme IIB-cellobiose
View Download 0.518 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.507 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.502 c.16.1 Lumazine synthase
View Download 0.501 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.497 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.471 c.26.1 Nucleotidylyl transferase
View Download 0.466 c.23.1 CheY-like
View Download 0.455 c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.443 c.47.1 Thioredoxin-like
View Download 0.430 c.23.1 CheY-like
View Download 0.429 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.425 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.422 d.74.4 Prokaryotic AspRS, insert domain
View Download 0.413 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.406 b.60.1 Lipocalins
View Download 0.399 c.47.1 Thioredoxin-like
View Download 0.397 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.393 c.23.1 CheY-like
View Download 0.367 c.121.1 Ribose/Galactose isomerase RpiB/AlsB
View Download 0.367 c.15.1 BRCT domain
View Download 0.357 c.20.1 Initiation factor IF2/eIF5b, domain 3
View Download 0.355 c.23.1 CheY-like
View Download 0.350 c.47.1 Thioredoxin-like
View Download 0.346 c.47.1 Thioredoxin-like
View Download 0.345 d.58.48 MTH1187-like
View Download 0.334 c.116.1 alpha/beta knot
View Download 0.333 c.8.6 Swiveling domain of the glycerol dehydratase reactivase alpha subunit
View Download 0.328 c.48.1 TK C-terminal domain-like
View Download 0.325 c.23.13 Type II 3-dehydroquinate dehydratase
View Download 0.306 c.47.1 Thioredoxin-like
View Download 0.299 c.50.1 Macro domain-like
View Download 0.290 c.47.1 Thioredoxin-like
View Download 0.287 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.283 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.282 d.58.5 GlnB-like
View Download 0.278 c.57.1 Molybdenum cofactor biosynthesis proteins
View Download 0.271 c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.263 c.24.1 Methylglyoxal synthase-like
View Download 0.259 c.23.4 Succinyl-CoA synthetase domains
View Download 0.258 c.54.1 IIA domain of mannose transporter, IIA-Man
View Download 0.252 c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.251 c.24.1 Methylglyoxal synthase-like
View Download 0.245 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.245 c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.242 d.58.7 RNA-binding domain, RBD
View Download 0.236 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.233 c.23.5 Flavoproteins
View Download 0.232 c.26.1 Nucleotidylyl transferase
View Download 0.226 c.48.1 TK C-terminal domain-like
View Download 0.226 a.61.1 Retroviral matrix proteins
View Download 0.226 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.224 c.48.1 TK C-terminal domain-like
View Download 0.221 c.78.2 Aspartate/glutamate racemase
View Download 0.213 c.26.1 Nucleotidylyl transferase
View Download 0.203 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.202 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.202 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain

Predicted functions:

Term Confidence Notes
binding 1.71761116975383 bayes_pls_golite062009
catalytic activity 0.942640875796745 bayes_pls_golite062009
hydrolase activity 0.799258945993812 bayes_pls_golite062009
protein binding 0.262528335081572 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.205823354338506 bayes_pls_golite062009
nucleic acid binding 0.18803512517078 bayes_pls_golite062009
purine nucleotide binding 0.144773327806905 bayes_pls_golite062009
nucleotide binding 0.140809536790465 bayes_pls_golite062009
purine ribonucleotide binding 0.134373265505829 bayes_pls_golite062009
ribonucleotide binding 0.134362467171752 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIKLREKSHL RFKIVNEDRR GRRQSLINNI TTQLKILDDK EKQMAPLMRP SWDSYFMKLA  60
   61 TLAASRSNCM KRRVGCVIVR ECRVIATGYN GTPRHLTNCF NGGCPRCNDG DSRNLHTCLC 120
  121 LHAEENALLE AGRDRVGQNA TLYCDTCPCL TCSVKIVQTG ISEVVYSQSY RMDEESFKVL 180
  181 KNAGITVRQF SFTEEPRIVM I

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.99
Match: 1jtkA
Description: mono-domain cytidine deaminase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle