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View Structure Prediction Details

Protein: GGA2
Organism: Saccharomyces cerevisiae
Length: 585 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GGA2.

Description E-value Query
Range
Subject
Range
GGA2 - Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p...
GGA2_YEAST - ADP-ribosylation factor-binding protein GGA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
gi|207344617 - gi|207344617|gb|EDZ71705.1| YHR108Wp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..585] [1..585]
GGA2 - golgi-associated, gamma adaptin ear containing, ARF binding protein 2
0.0 [5..585] [6..607]
gi|12835938 - gi|12835938|dbj|BAB23426.1| unnamed protein product [Mus musculus]
0.0 [14..585] [17..597]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [49..583] [3..601]
YB0G_SCHPO - Probable ADP-ribosylation factor-binding protein C25H2.16c OS=Schizosaccharomyces pombe (strain 972 ...
SPBC25H2.16c - adaptin
0.0 [29..582] [11..530]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHPHSHSIY LSELPVRKPQ ALGNPLLRKI QRACRMSLAE PDLALNLDIA DYINEKQGAA  60
   61 PRDAAIALAK LINNRESHVA IFALSLLDVL VKNCGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 177.626727
Match: 1elkA_
Description: Tom1 protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [97-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFHLQISRKE FLNELVKRFP GHPPLRYSKI QRLILTAIEE WYQTICKHSS YKNDMGYIRD  60
   61 MHRLLKYKGY AFPKISESDL AVLKPSNQLK TASEIQKEQE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 177.626727
Match: 1elkA_
Description: Tom1 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 5.9355718186759 bayes_pls_golite062009
binding 2.36215929275587 bayes_pls_golite062009
phosphoinositide binding 1.69886980741044 bayes_pls_golite062009
protein binding 1.55859524125292 bayes_pls_golite062009
phospholipid binding 1.35873451348399 bayes_pls_golite062009
lipid binding 0.681936854618139 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 0.2359206178887 bayes_pls_golite062009
phosphatidylinositol binding 0.10007172207713 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [197-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAQAAKLEEL IRRGKPEDLR EANKLMKIMA GFKEDNAVQA KQAISSELNK LKRKADLLNE  60
   61 MLESPDSQNW DNETTQELHS ALKVAQPKFQ KIIEEEQEDD ALVQDLLKFN DTVNQLLEKF 120
  121 NLLKNGDSNA ASQIHPSHVS A

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 3.0
Match: PF03127
Description: GAT domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [338-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLQQSSGALT NEINLIDFND LDEAPSQGNN NTNGTGTPAA AETSVNDLLG DLTDLSISNP  60
   61 STANQASFGL GGDIVLGSSQ PAPPVTTTNN SNNTLDLLGL STPQSPTN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.93554535044651 bayes_pls_golite062009
protein binding 1.17960228368657 bayes_pls_golite062009
transporter activity 0.169557557237959 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [446-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQAVNSSGFD LLMGFNPTTG TTTAPARTLV NQSPNLKIEF EISRESNSVI RIKSFFTNLS  60
   61 SSPISNLVFL LAVPKSMSLK LQPQSSNFMI GNAKDGISQE GTIENAPANP SKALKVKWKV 120
  121 NYSVNSTQAE ETAVFTLPNV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1iu1A_
Description: Gamma1-adaptin domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle