YRC Public Data Repository - Protein Structure Prediction

Protein:	HXT5
Organism:	Saccharomyces cerevisiae
Length:	592 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HXT5.

Description	E-value	Query Range	Subject Range
HXT5_YEAST - Probable glucose transporter HXT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT5 P... HXT5 - Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable ca... gi\|190405875 - gi\|190405875\|gb\|EDV09142.1\| low-affinity glucose transporter [Saccharomyces cerevisiae RM11-1a] gi\|151944042 - gi\|151944042\|gb\|EDN62335.1\| hexose transporter [Saccharomyces cerevisiae YJM789]	0.0	[1..592]	[1..592]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1	0.0	[1..587]	[1..565]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[28..591]	[9..570]

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Predicted Domain #1

Region A:
Residues: [1-58]

      1          11         21         31         41         51         
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    1 MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV SSYISHEG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.322	d.58.17	Metal-binding domain
View	Download	0.498	a.60.12	DNA polymerase beta-like, second domain
View	Download	0.342	a.60.2	RuvA domain 2-like
View	Download	0.401	a.20.1	PGBD-like
View	Download	0.308	a.60.2	RuvA domain 2-like
View	Download	0.292	a.159.2	FF domain
View	Download	0.209	d.58.23	Probable ACP-binding domain of malonyl-CoA ACP transacylase

Predicted Domain #2

Region A:
Residues: [59-278]

      1          11         21         31         41         51         
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    1 PPKDELEELQ KEVDKQLEKK SKSDLLFVSV CCLMVAFGGF VFGWDTGTIS GFVRQTDFIR  60
   61 RFGSTRANGT TYLSDVRTGL MVSIFNIGCA IGGIVLSKLG DMYGRKIGLM TVVVIYSIGI 120
  121 IIQIASIDKW YQYFIGRIIS GLGVGGITVL APMLISEVSP KQLRGTLVSC YQLMITFGIF 180
  181 LGYCTNFGTK NYSNSVQWRV PLGLCFAWSI FMIVGMTFVP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [324-538]

      1          11         21         31         41         51         
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    1 ERLAGSASWG ELVTGKPQMF RRTLMGMMIQ SLQQLTGDNY FFYYGTTIFQ AVGLEDSFET  60
   61 AIVLGVVNFV STFFSLYTVD RFGRRNCLLW GCVGMICCYV VYASVGVTRL WPNGQDQPSS 120
  121 KGAGNCMIVF ACFYIFCFAT TWAPVAYVLI SESYPLRVRG KAMSIASACN WIWGFLISFF 180
  181 TPFITSAINF YYGYVFMGCM VFAYFYVFFF VPETK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	476.218487
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	5.74077413704789	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	2.63293544825311	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar binding	0.285073104957756	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [279-323]

      1          11         21         31         41         51         
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    1 ESPRYLVEVG KIEEAKRSLA RANKTTEDSP LVTLEMENYQ SSIEA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [539-592]

      1          11         21         31         41         51         
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    1 GLTLEEVNEM YEENVLPWKS TKWIPPSRRT TDYDLDATRN DPRPFYKRMF TKEK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	476.218487
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: