YRC Public Data Repository - Protein Structure Prediction

Protein:	ARN2
Organism:	Saccharomyces cerevisiae
Length:	637 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARN2.

Description	E-value	Query Range	Subject Range
ARN2 - Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron c...	0.0	[1..637]	[1..637]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	3.0E-90	[50..588]	[12..524]
gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini] gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]	2.0E-89	[11..602]	[2..588]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-85	[36..586]	[14..533]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	3.0E-83	[5..596]	[78..639]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	1.0E-81	[58..581]	[1..501]
gi\|16944692 - gi\|16944692\|emb\|CAC28808.2\| related to tetracycline efflux protein (otrb) [Neurospora crassa]	2.0E-81	[35..599]	[14..580]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	3.0E-81	[58..581]	[1..501]

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Predicted Domain #1

Region A:
Residues: [1-53]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS LII

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.302	a.4.1	Homeodomain-like
View	Download	0.283	a.60.1	SAM/Pointed domain
View	Download	0.299	a.60.12	DNA polymerase beta-like, second domain
View	Download	0.285	a.164.1	C-terminal domain of DFF45/ICAD (DFF-C domain)
View	Download	0.270	a.4.11	RNA polymerase subunit RPB10

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
anion transmembrane transporter activity	1.24023641504332	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [54-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKSELMAKKY DTWQLKAIFL FSAFICTFAY GLDSSIRGTY MTYAMNSYSA HSLISTVSVI  60
   61 VLMISAVSQV IFGGLSDIFG RLTLFLVSIV LYIVGTIIQS QAYDVQRYAA GAVFYYVGLV 120
  121 GVMLQVVLML SDNSSLKWRL FYTLIPSWPS IITTWVSGSV VEAANPLENW SWNIAMWAFI 180
  181 FPLCCIPLIL CMLHMRWKVR NDVEWKELQD EKSYYQT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.30103
Match:	1lviA_
Description:	No description for 1lviA_ was found.

Predicted Domain #3

Region A:
Residues: [271-329]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL VPLTLAGGVS TNWRNSKIIG PFVLGFVLV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.359	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.404	a.60.1	SAM/Pointed domain
View	Download	0.386	a.144.1	PABC (PABP) domain
View	Download	0.606	d.48.1	RecA protein, C-terminal domain
View	Download	0.376	a.60.1	SAM/Pointed domain
View	Download	0.314	d.88.1	SRF-like
View	Download	0.297	a.5.7	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View	Download	0.281	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.280	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.276	d.58.5	GlnB-like
View	Download	0.262	d.58.40	D-ribose-5-phosphate isomerase (RpiA), lid domain
View	Download	0.229	d.15.3	MoaD/ThiS
View	Download	0.228	d.51.1	Eukaryotic type KH-domain (KH-domain type I)
View	Download	0.200	g.58.1	Pheromone ER-23

Predicted Domain #4

Region A:
Residues: [330-637]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGFIYWESRL ALVPFAPFKL LKDRGVWAPL GIMFFICFVY QMAAGYLYTI LVVAVDESAS  60
   61 SATRIINLYS FVTAVVAPFL GLIVTRSSRL KSYIIFGGSL YFITMGLFYR YRSGQDADGG 120
  121 IIAGMVIWGL SSCLFDYPTI VSIQSVTSHE NMATVTALNY TVFRIGGAVA AAISGAIWTQ 180
  181 SLYPKLLHYM GDADLATAAY GSPLTFILSN PWGTPVRSAM VEAYRHVQKY EVIVALVFSA 240
  241 PMFLLTFCVR DPRLTEDFAQ KLPDREYVQT KEDDPINDWI AKRFAKALGG HKKDLQNPNR 300
  301 ICVRKNDL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: