| Protein: | MDR1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 950 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDR1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..950] | [1..950] |
|
|
0.0 | [23..918] | [15..834] |
|
|
0.0 | [23..911] | [15..827] |
|
|
0.0 | [7..720] | [24..755] |
|
|
0.0 | [9..650] | [266..897] |
|
Region A: Residues: [1-164] |
1 11 21 31 41 51
| | | | | |
1 MSFFDSLRQK APFLDKLADS FTPTLTRDEK FRLKYKLPAN ENILEDTNAE VSFATSIKDG 60
61 KGHSDRVNNK GRKTAYVYSG RLFLTPHFLV FRDAFDHSSC VLILNISTIK RVERSPSESY 120
121 EFALLVTLYT GAKVLIQFIG IRYRSEQFCD KLKLNLKENI PNAK
|
| Detection Method: |  |
| Confidence: | 21.420216 |
| Match: | PF02893 |
| Description: | GRAM domain |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [165-369] |
1 11 21 31 41 51
| | | | | |
1 TLPAFLETSY SEFLIAKNIL GKKDITVPRA GLGQHFKYPG NPTMVKEKAK LRLWFDYFRE 60
61 NGRNLAVVQT PMFRKLIRIG VPNRMRGEIW ELCSGAMYMR YANSGEYERI LNENAGKTSQ 120
121 AIDEIEKDLK RSLPEYSAYQ TEEGIQRLRN VLTAYSWKNP DVGYCQAMNI VVAGFLIFMS 180
181 EEQAFWCLCN LCDIYVPGYY SKTMY
|
|
Region B: Residues: [423-453] |
1 11 21 31 41 51
| | | | | |
1 RIMDIFFMNG SITLFQVALA VLKINADDIL Q
|
| Detection Method: | |
| Confidence: | 43.154902 |
| Match: | 1fkmA_ |
| Description: | Ypt/Rab-GAP domain of gyp1p |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [370-422] |
1 11 21 31 41 51
| | | | | |
1 GTLLDQRVFE SFVEDRMPVL WEYILQHDIQ LSVVSLPWFL SLFFTSMPLE YAV
|
| Detection Method: | |
| Confidence: | 43.154902 |
| Match: | 1fkmA_ |
| Description: | Ypt/Rab-GAP domain of gyp1p |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 2.08545912858984 | bayes_pls_golite062009 |
| protein binding | 1.56086942180613 | bayes_pls_golite062009 |
| calcium ion binding | 1.33959449723205 | bayes_pls_golite062009 |
| cation binding | 1.09340191610586 | bayes_pls_golite062009 |
| metal ion binding | 1.09340191610586 | bayes_pls_golite062009 |
| ion binding | 1.08592956217627 | bayes_pls_golite062009 |
|
Region A: Residues: [454-522] |
1 11 21 31 41 51
| | | | | |
1 ADDDGMFIAI IKHYFQTLGQ SAHPDSSDIK YRQITKFQEL LVTAFKEFSV ISEEMAMHAR 60
61 HKYEKGIFQ
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.649 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.592 | a.21.1 | HMG-box |
| View | Download | 0.658 | d.212.1 | TolA/TonB C-terminal domain |
| View | Download | 0.734 | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.740 | i.1.1 | Ribosome and ribosomal fragments |
| View | Download | 0.581 | d.68.6 | DNA-binding protein Sso10b (AlbA) |
| View | Download | 0.579 | a.4.7 | Ribosomal protein L11, C-terminal domain |
| View | Download | 0.562 | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.558 | c.25.1 | Ferredoxin reductase-like, C-terminal NADP-linked domain |
| View | Download | 0.552 | a.65.1 | Annexin |
| View | Download | 0.551 | d.52.7 | Ribosome-binding factor A, RbfA |
| View | Download | 0.522 | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.508 | f.30.1 | Photosystem I reaction center subunit X, PsaK |
| View | Download | 0.503 | a.64.1 | Saposin |
| View | Download | 0.458 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.444 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.430 | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.426 | d.68.7 | R3H domain |
| View | Download | 0.422 | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.406 | a.118.13 | Arp2/3 complex 16 kDa subunit ARPC5 |
| View | Download | 0.402 | a.8.3 | Families 57/38 glycoside transferase middle domain |
| View | Download | 0.382 | a.24.11 | Bacterial GAP domain |
| View | Download | 0.364 | a.126.1 | Serum albumin-like |
| View | Download | 0.355 | a.4.13 | Sigma3 and sigma4 domains of RNA polymerase sigma factors |
| View | Download | 0.354 | a.2.10 | Epsilon subunit of F1F0-ATP synthase C-terminal domain |
| View | Download | 0.352 | a.2.8 | Eukaryotic DNA topoisomerase I, dispensable insert domain |
| View | Download | 0.349 | a.179.1 | Replisome organizer (g39p helicase loader/inhibitor protein) |
| View | Download | 0.347 | a.151.1 | Glutamyl tRNA-reductase dimerization domain |
| View | Download | 0.333 | a.159.2 | FF domain |
| View | Download | 0.323 | a.66.1 | Transducin (alpha subunit), insertion domain |
| View | Download | 0.319 | a.72.1 | Functional domain of the splicing factor Prp18 |
| View | Download | 0.314 | a.2.3 | Chaperone J-domain |
| View | Download | 0.304 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.304 | a.2.7 | tRNA-binding arm |
| View | Download | 0.294 | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.290 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.286 | a.8.2 | Plasmid maintenance system epsilon/zeta, antidote epsilon subunit |
| View | Download | 0.286 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.285 | a.90.1 | Transcription factor STAT-4 N-domain |
| View | Download | 0.280 | a.2.3 | Chaperone J-domain |
| View | Download | 0.276 | d.68.1 | Translation initiation factor IF3, C-terminal domain |
| View | Download | 0.273 | a.161.1 | beta-catenin-interacting protein ICAT |
| View | Download | 0.271 | d.58.49 | YajQ-like |
| View | Download | 0.270 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.269 | f.15.1 | Small-conductance potassium channel |
| View | Download | 0.269 | d.122.1 | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase |
| View | Download | 0.267 | a.112.1 | Description not found. |
| View | Download | 0.264 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.263 | a.4.1 | Homeodomain-like |
| View | Download | 0.262 | d.52.5 | Probable GTPase Der, C-terminal domain |
| View | Download | 0.261 | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.261 | d.39.1 | Dynein light chain 8 (DLC8) |
| View | Download | 0.258 | g.63.1 | Mollusk pheromone |
| View | Download | 0.251 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.250 | a.60.1 | SAM/Pointed domain |
| View | Download | 0.250 | a.3.1 | Cytochrome c |
| View | Download | 0.249 | a.3.1 | Cytochrome c |
| View | Download | 0.246 | a.77.1 | DEATH domain |
| View | Download | 0.246 | a.3.1 | Cytochrome c |
| View | Download | 0.245 | a.28.1 | ACP-like |
| View | Download | 0.243 | a.60.2 | RuvA domain 2-like |
| View | Download | 0.239 | a.7.7 | BAG domain |
| View | Download | 0.238 | d.15.6 | Superantigen toxins, C-terminal domain |
| View | Download | 0.236 | a.17.1 | p8-MTCP1 |
| View | Download | 0.232 | a.4.1 | Homeodomain-like |
| View | Download | 0.230 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.228 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.227 | a.2.10 | Epsilon subunit of F1F0-ATP synthase C-terminal domain |
| View | Download | 0.227 | a.24.3 | Cytochromes |
| View | Download | 0.226 | a.42.1 | MDM2 |
| View | Download | 0.221 | a.4.12 | TrpR-like |
| View | Download | 0.220 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.218 | a.47.2 | t-snare proteins |
| View | Download | 0.217 | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.215 | a.21.1 | HMG-box |
| View | Download | 0.211 | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.209 | a.64.1 | Saposin |
| View | Download | 0.208 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.207 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.207 | a.4.1 | Homeodomain-like |
| View | Download | 0.206 | a.4.8 | Ribosomal protein S18 |
| View | Download | 0.203 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.200 | c.25.1 | Ferredoxin reductase-like, C-terminal NADP-linked domain |
|
Region A: Residues: [523-637] |
1 11 21 31 41 51
| | | | | |
1 NIETFMKRTQ LRHMPKTFNL SSDDLSNIYD MFYQSIETYK ISMGTGSSNM GFEVFIQFLS 60
61 KFCDSCRPCE KDKDPAFRKQ KRNFLQRLFD NWDSAHIGEL TLNDVVTGLD KLVTV
|
| Detection Method: | |
| Confidence: | 57.66807 |
| Match: | 1iku__ |
| Description: | Recoverin |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [638-766] |
1 11 21 31 41 51
| | | | | |
1 DLLQAINYFF SLYDTDGDGE LHREEVLQLS EGLLLLTEPW KSGRYVDLLT KKRIEDDIAE 60
61 NIIKESGGEI ATMNQIELPT GVTIDEEKYK VEQAERYLKA ASNFLQRSFE YAKAVDLAEE 120
121 VNLIDLSDD
|
| Detection Method: | |
| Confidence: | 57.66807 |
| Match: | 1iku__ |
| Description: | Recoverin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [767-950] |
1 11 21 31 41 51
| | | | | |
1 EGEEKRTVKQ KQLESIKANA ALDPTHPKVI DLPTFRMIIL ADETYELFFS NTLRSSVHVD 60
61 EHVNIDNKNK VLRSMFDGIL ADGKRVAEQV RRRVDSVATR SSIASVESTP TAAASSITTK 120
121 EEKYDDLDDF TSEHQPENEE LLQSSWFEID DANETSTKAI QERSFEPLSA NSSEEKSNLI 180
181 EFEA
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
