YRC Public Data Repository - Protein Structure Prediction

Protein:	TFG2
Organism:	Saccharomyces cerevisiae
Length:	400 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFG2.

Description	E-value	Query Range	Subject Range
gi\|639703 - gi\|639703\|gb\|AAA61642.1\| transcription initiation factor TFIIF middle subunit	0.0	[1..400]	[1..400]
T2FB_XENLA - General transcription factor IIF subunit 2 OS=Xenopus laevis GN=gtf2f2 PE=2 SV=1	1.0E-81	[56..363]	[7..262]
T2FB_SCHPO - Transcription initiation factor IIF subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 248... tfg2 - transcription factor TFIIF complex beta subunit Tfg2	3.0E-55	[163..356]	[59..253]
gi\|15231173 - gi\|15231173\|ref\|NP_190795.1\| ATP binding / RNA polymerase II transcription factor [Arabidopsis thali...	4.0E-50	[208..361]	[212..364]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	6.0E-48	[208..361]	[212..376]
gi\|19073998, gi\|... - gi\|19073998\|ref\|NP_584604.1\| TRANSCRIPTION INITIATION FACTOR TFIIF BETA SUBUNIT [Encephalitozoon cun... gi\|19073998 - ref\|NP_584604.1\| TRANSCRIPTION INITIATION FACTOR TFIIF BETA SUBUNIT [Encephalitozoon cuniculi]	9.0E-46	[198..357]	[74..228]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGSAGAPA LSNNSTNSVA KEKSGNISGD EYLSQEEEVF DGNDIENNET KVYEESLDLD  60
   61 LERSNRQVWL VRLPMFLAEK WRDRNNLHGQ ELGKIRINKD GSKITLLLNE NDNDSIPHEY 120
  121 DLELTKKVVE NEYVFTEQNL KKYQQRKKEL EADPEKQRQA YLKKQEREEE LKKKQQQQKR 180
  181 RNNRKKFNHR VMTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.502279
Match:	1f3uA_
Description:	TFIIF beta subunit, Rap30
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA polymerase II transcription factor activity	4.06672086326535	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [195-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDGRDRYIPY VKTIPKKTAI VGTVCHECQV MPSMNDPNYH KIVEQRRNIV KLNNKERITT  60
   61 LDETVGVTMS HTGMS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [270-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSDNSNFLK VGREKAKSNI KSIRMPKKEI LDYLFKLFDE YDYWSLKGLK ERTRQPEAHL  60
   61 KECLDKVATL VKKGPYAFKY TLRPEYKKLK EEERKATLGE LADEQTGSAG DNAQGDAEAD 120
  121 LEDEIEMEDV V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.9794
Match:	1bby__
Description:	DNA-binding domain from rap30
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: