YRC Public Data Repository - Protein Structure Prediction

Protein:	PDE1
Organism:	Saccharomyces cerevisiae
Length:	369 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDE1.

Description	E-value	Query Range	Subject Range
gi\|172229 - gi\|172229\|gb\|AAA34896.1\| low-affinity cyclic AMP phosphodiesterase	0.0	[1..369]	[1..369]
cgs2 - cAMP-specific phosphodiesterase Cgs2 PDE1_SCHPO - 3',5'-cyclic-nucleotide phosphodiesterase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...	1.0E-98	[4..343]	[25..321]
PDE1_CANAX - 3',5'-cyclic-nucleotide phosphodiesterase OS=Candida albicans GN=PDE1 PE=3 SV=2	1.0E-97	[4..369]	[3..426]
CPDP_YERPE - Probable 3',5'-cyclic-nucleotide phosphodiesterase OS=Yersinia pestis GN=cpdP PE=3 SV=1 gi\|149365411, gi... - gi\|149365411\|ref\|ZP_01887446.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis ... gi\|16122901, gi\|... - gi\|218929769\|ref\|YP_002347644.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis...	7.0E-94	[49..349]	[38..326]
CPDP_ALIFS - 3',5'-cyclic-nucleotide phosphodiesterase OS=Aliivibrio fischeri GN=cpdP PE=3 SV=1	1.0E-82	[51..367]	[28..328]
PDE1_DICDI - cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A OS=Dictyostelium discoideum GN=pdsA PE=1 SV=... gi\|60466382, gi\|... - gi\|66808451\|ref\|XP_637948.1\| cAMP phosphodiesterase [Dictyostelium discoideum AX4], gi\|60466382\|gb\|E...	9.0E-72	[53..367]	[91..450]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-71	[53..367]	[91..450]

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Predicted Domain #1

Region A:
Residues: [1-369]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVFEITILG ANGGPTEYGT QCFILKPART EDPELIAVDG GAGMYQLREM LVQGRNENEG  60
   61 DDELVPSFYE HDREPIEFFI DSKLNIQKGL SKSLLQSLKR QGEHFESANT MKKTYEVFQG 120
  121 ITDYYITHPH LDHISGLVVN SPSIYEQENS KKKTIWGLPH TIDVLQKHVF NDLIWPDLTA 180
  181 ERSRKLKLKC LNPKEVQKCT IFPWDVIPFK VHHGIGVKTG APVYSTFYIF RDRKSKDCII 240
  241 VCGDVEQDRR ESEESLLEEF WSYVAENIPL VHLKGILVEC SCPLSSKPEQ LYGHLSPIYL 300
  301 INELSNLNTL YNSSKGLSGL NVIVTHVKST PAKRDPRLTI LEELRFLAEE RNLGDLRISI 360
  361 ALEGHTLFL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	199.040959
Match:	PF02112
Description:	cAMP phosphodiesterases class-II

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	2.09756389235564	bayes_pls_golite062009
binding	1.51011379036442	bayes_pls_golite062009
protein binding	1.25434116276809	bayes_pls_golite062009
catalytic activity	0.888964130802536	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: