YRC Public Data Repository - Protein Structure Prediction

Protein:	CHC1
Organism:	Saccharomyces cerevisiae
Length:	1653 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CHC1.

Description	E-value	Query Range	Subject Range
CLH_DICDI - Clathrin heavy chain OS=Dictyostelium discoideum GN=chcA PE=1 SV=1 gi\|66818048, gi\|... - gi\|66818048\|ref\|XP_642717.1\| clathrin heavy chain [Dictyostelium discoideum AX4], gi\|60470824\|gb\|EAL...	0.0	[1..1637]	[1..1632]
gi\|9257202, gi\|1... - gi\|9257202\|ref\|NP_009029.1\| clathrin, heavy polypeptide-like 1 isoform b [Homo sapiens], gi\|1408232\|...	0.0	[4..1620]	[5..1614]
gi\|12322717 - gi\|12322717\|gb\|AAG51341.1\|AC012562_2 putative clathrin heavy chain, 3' partial; 6334-1 [Arabidopsis ...	0.0	[2..1272]	[4..1280]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[4..1632]	[5..1628]
FBpp0308531, Chc... - The gene Clathrin heavy chain is referred to in FlyBase by the symbol Dmel\Chc (CG9012, FBgn0000319)... gi\|220947606 - gi\|220947606\|gb\|ACL86346.1\| Chc-PA [synthetic construct]	0.0	[4..1650]	[5..1652]
CLH_YEAST - Clathrin heavy chain OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CHC1 PE=1 SV=1 CHC1 - Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport ...	0.0	[1..1653]	[1..1653]
gi\|18250637 - gi\|18250637\|emb\|CAD20886.1\| clathrin heavy-chain [Gallus gallus]	0.0	[4..1648]	[5..1647]

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Predicted Domain #1

Region A:
Residues: [1-12]

      1          11         21         31         41         51         
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    1 MSDLPIEFTE LV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [199-362]

      1          11         21         31         41         51         
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    1 GHVAIFTNIL LEGNGSTPVQ VFVTGNRNAT TGAGELRIIE IDHDASLPSQ YQKETTDIFF  60
   61 PPDATNDFPI AVQVSEKYGI IYLLTKYGFI HLYELETGTN LFVNRITAES VFTAAPYNHE 120
  121 NGIACINKKG QVLAVEISTS QIVPYILNKL SNVALALIVA TRGG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2230.0
Match:	1bpoA_
Description:	Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [13-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLMSLGISPQ FLDFRSTTFE SDHFVTVRET KDGTNSVAIV DLAKGNEVTR KNMGGDSAIM  60
   61 HPSQMVISVR ANGTIVQIFN LETKSKLKSF TLDEPVIFWR WLSETTLGFV TARSILTSNV 120
  121 FDGNVNAKPQ LL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [363-430]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPGADDLFQK QFESLLLQND YQNAAKVAAS STSLRNQNTI NRLKNIQAPP GAISPILLYF  60
   61 STLLDKGK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2230.0
Match:	1bpoA_
Description:	Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [145-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLRHANLNNT QIINFVANKN LDWFAVVGIL QENGRIAGRI QLFSKQRNIS QAID

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [431-498]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNKEETIELA RPVLQQDRKQ LFEKWLKEDK LECSEELGDI VKPFDTTLAL ACYLRAGAHA  60
   61 KVISCLAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2230.0
Match:	1bpoA_
Description:	Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [499-561]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQQFEKIIPY CQKVGYQPNF LVLISSLIRS SPDRASEFAV SLLQNPETAS QIDIEKIADL  60
   61 FFS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	12.01
Match:	1m9iA
Description:	Annexin VI
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [562-806]

      1          11         21         31         41         51         
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    1 QNHIQQGTSL LLDALKGDTP DQGHLQTRVL EVNLLHAPQV ADAILGNNIF SHYDKPTIAS  60
   61 LSEKAGLYQR ALENYTDIKD IKRCVVHTNA LPIDWLVGYF GKLNVEQSLA CLKALMDNNI 120
  121 QANIQTVVQV ATKFSDLIGP STLIKLFEDY NATEGLYYYL ASLVNLTEDK DVVYKYIEAA 180
  181 AKMKQYREIE RIVKDNNVYD PERVKNFLKD ANLEDQLPLV IVCDRFDFVH EMILYLYKSQ 240
  241 NLKFI

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	12.01
Match:	1m9iA
Description:	Annexin VI
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [807-822]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETYVQQVNPS KTAQVV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [894-1077]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSPEKFLKEN DQYDTLDVGH YCEKRDPYLA YIAYEKGQND DDLIRITNEN SMYKYQARYL  60
   61 LERSDLDLWN KVLNQENIHR RQLIDSVISV GIPELTDPEP VSLTVQAFMT NGLKLELIEL 120
  121 LEKIILEPSP FNENVALQGL LLLSAIKYEP TKVSSYIEKL DNYDADEIAP LCIEHDLKEE 180
  181 AFEI

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	12.01
Match:	1m9iA
Description:	Annexin VI
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [823-893]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GALLDMDCDE AFIQSLLQSV LGQVPINELT TEVEKRNRLK ILLPFLEQSL SQGIQDQAVY  60
   61 NALAKIYIDS N

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	12.01
Match:	1m9iA
Description:	Annexin VI
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [1078-1550]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDKHEMYGKA LKVLIEDIMS LDRAASYADK INTPELWSQI GTAQLDGLRI PDAIESYIKA  60
   61 EDPSNYENVI DIAEQAGKYE ELIPFLLMAR KTLKEPKIDG ALILAYAELN KIHEIENLLA 120
  121 GSNVANLDHV GDKLFENKEY KAARLCYSAV SNYSKLASTL VYLGDYQAAV DTARKASNIK 180
  181 VWKLVNDACI EKKEFKLAQI CGLNLIVHAE ELDELVERYE SNGYFEELIS LFEAGLGLER 240
  241 AHMGMFTELA ILYSKYEPDK TFEHLKLFWS RINIPKVIRA VEQAHLWSEL VFLYAHYDEW 300
  301 DNAALTLIEK STKDLDHAYF KEVVVKVSNL EIYYKAINFY VKFHPSLLVD LLTSLTPRLD 360
  361 IPRTVKIFSK SDNLPLIKPF LINVLPKNNS VVNQAYHDLM IEEEDYKALQ DAVDSYDKFD 420
  421 QLGLASRLES HKLIFFKKIG ALLYRRNKKW AKSLSILKEE KLWKDAIETA AIS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2330.0
Match:	1b89A_
Description:	Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1551-1653]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDPKVVEALL TYFVETGNRE GFVALLYAAY NLVRIEFVLE ISWMNSLEDY IKPFEISIKK  60
   61 EQNDSIKKIT EELAKKSGSN EEHKDGQPLM LMNSAMNVQP TGF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.447	0.197	structural molecule activity	a.73.1	Retrovirus capsid protein, N-terminal core domain
View	Download	0.448	0.189	vesicle-mediated transport	a.118.8	TPR-like
View	Download	0.843	0.106	structural molecule activity	d.55.1	Ribosomal protein L22
View	Download	0.499	0.002	clathrin vesicle coat	a.23.4	Mitochondrial import receptor subunit Tom20
View	Download	0.421	0.002	clathrin vesicle coat	a.92.1	Carbamoyl phosphate synthetase, large subunit connection domain
View	Download	0.402	N/A	N/A	a.118.14	FliG
View	Download	0.388	N/A	N/A	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.380	N/A	N/A	a.118.9	ENTH/VHS domain
View	Download	0.378	N/A	N/A	c.26.3	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
View	Download	0.370	N/A	N/A	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.342	N/A	N/A	d.68.7	R3H domain
View	Download	0.334	N/A	N/A	a.118.18	Cysteine rich protein B (HcpB)
View	Download	0.323	N/A	N/A	a.11.1	Acyl-CoA binding protein
View	Download	0.322	N/A	N/A	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.312	N/A	N/A	a.1.1	Globin-like
View	Download	0.302	N/A	N/A	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.295	N/A	N/A	c.59.1	MurD-like peptide ligases, peptide-binding domain
View	Download	0.277	N/A	N/A	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.277	N/A	N/A	a.118.8	TPR-like
View	Download	0.260	N/A	N/A	a.50.1	Anaphylotoxins (complement system)
View	Download	0.258	N/A	N/A	a.65.1	Annexin
View	Download	0.258	N/A	N/A	a.76.1	Iron-dependent represor protein, dimerization domain
View	Download	0.256	N/A	N/A	a.158.1	F-box domain
View	Download	0.256	N/A	N/A	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.254	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.246	N/A	N/A	a.77.1	DEATH domain
View	Download	0.245	N/A	N/A	a.37.1	A DNA-binding domain in eukaryotic transcription factors
View	Download	0.240	N/A	N/A	d.93.1	SH2 domain
View	Download	0.230	N/A	N/A	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.227	N/A	N/A	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.225	N/A	N/A	a.29.4	RecG, N-terminal domain
View	Download	0.221	N/A	N/A	d.110.2	GAF domain-like
View	Download	0.218	N/A	N/A	a.26.1	4-helical cytokines
View	Download	0.217	N/A	N/A	a.133.1	Phospholipase A2, PLA2
View	Download	0.209	N/A	N/A	a.101.1	Uteroglobin-like
View	Download	0.204	N/A	N/A	f.34.1	Mechanosensitive channel protein MscS (YggB), transmembrane region
View	Download	0.203	N/A	N/A	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.200	N/A	N/A	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits