YRC Public Data Repository - Protein Structure Prediction

Protein:	ARI1
Organism:	Saccharomyces cerevisiae
Length:	347 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARI1.

Description	E-value	Query Range	Subject Range
gi\|209753446, gi... - pir\|\|A91219 dTDP-glucose 4,6-dehydratase [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|189362621, gi... - gi\|189362621\|gb\|EDU81040.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4486], gi\|... gi\|189365802, gi... - gi\|189365802\|gb\|EDU84218.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4501], gi\|... gi\|13364196, gi\|... - gi\|15833975\|ref\|NP_312748.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7], gi\|13364196\|db... gi\|189358938, gi... - gi\|189358938\|gb\|EDU77357.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|168751746, gi... - gi\|188014279\|gb\|EDU52401.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|217325882, gi... - gi\|217325882\|ref\|ZP_03441966.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. TW14588]... gi\|209399629, gi... - gi\|209399629\|ref\|YP_002273306.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4115]... gi\|13364196, gi\|... - gi\|15833975\|ref\|NP_312748.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|189376800, gi... - gi\|189376800\|gb\|EDU95216.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|189373224, gi... - gi\|189373224\|gb\|EDU91640.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC869], gi\|1... gi\|168780684, gi... - gi\|189001405\|gb\|EDU70391.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|168775664, gi... - gi\|187768885\|gb\|EDU32729.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|208818281, gi... - gi\|208818281\|ref\|ZP_03258601.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4042],... gi\|208813029, gi... - gi\|208813029\|ref\|ZP_03254358.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4045],... gi\|254595186, gi... - gi\|254795786\|ref\|YP_003080623.1\| dTDP-D-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. TW143... gi\|208725490, gi... - gi\|208805689\|ref\|ZP_03248026.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4206],... gi\|195938077 - gi\|195938077\|ref\|ZP_03083459.1\| dTDP-glucose 4,6-dehydratase [Escherichia coli O157:H7 str. EC4024]	0.0	[6..345]	[3..336]
RMLB_SHIFL - dTDP-glucose 4,6-dehydratase OS=Shigella flexneri GN=rfbB PE=3 SV=2 gi\|24052449, gi\|... - gi\|24113426\|ref\|NP_707936.1\| dTDP-glucose 4,6 dehydratase [Shigella flexneri 2a str. 301], gi\|240524... gi\|30063492, gi\|... - gi\|30063492\|ref\|NP_837663.1\| dTDP-glucose 4,6 dehydratase [Shigella flexneri 2a str. 2457T], gi\|3004...	0.0	[6..345]	[2..339]
gi\|29139332, gi\|... - gi\|29143697\|ref\|NP_807039.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica serov... gi\|16762208 - gi\|16762208\|ref\|NP_457825.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica serov... gi\|213648374 - gi\|213648374\|ref\|ZP_03378427.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica se... gi\|213855008 - gi\|213855008\|ref\|ZP_03383248.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica se... gi\|214001944 - gi\|214001944\|ref\|ZP_03412679.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica se... gi\|16504512, gi\|... - gi\|25292366\|pir\|\|AH0921 UDP-N-acetylglucosamine epimerase (UDP-GlcNAc-2-epimerase) [imported] - Salm... gi\|213051692 - gi\|213051692\|ref\|ZP_03344570.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica se... gi\|213426572 - gi\|213426572\|ref\|ZP_03359322.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica se...	0.0	[5..344]	[2..335]
gi\|16611766 - gi\|16611766\|gb\|AAL27347.1\|AF402315_2 dTDP-D-glucose 4,6-dehydratase [Shigella boydii]	0.0	[6..343]	[2..337]
gi\|9957845 - gi\|9957845\|gb\|AAG09522.1\|AF279621_1 dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]	0.0	[6..343]	[2..337]
gi\|197264413, gi... - gi\|197264413\|ref\|ZP_03164487.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica se... gi\|167994617, gi... - gi\|205327551\|gb\|EDZ14315.1\| dTDP-glucose 4,6-dehydratase [Salmonella enterica subsp. enterica serova... lcl\|NC_016856.1_... - [gene=rffG] [protein=dTDP-glucose 4,6-dehydratase] [protein_id=YP_005240184.1] [location=4145370..41... gi\|16422490, gi\|... - gi\|6960275\|gb\|AAF33465.1\| 89% identity with E. coli dTDP-D-glucose-4,6-dehydratase (RFFG) (SP:P27830...	0.0	[5..344]	[2..335]
gi\|170081671, gi... - gi\|170081671\|ref\|YP_001730991.1\| dTDP-glucose 4,6 dehydratase, NAD(P)-binding [Escherichia coli str.... EG12412 - dTDP-glucose 4,6 dehydratase, NAD(P)-binding / TDP-glucose oxidoreductase-4,6 dehydratase gi\|1736731, gi\|8... - gi\|89108861\|ref\|AP_002641.1\| dTDP-glucose 4,6 dehydratase, NAD(P)-binding [Escherichia coli str. K-1... EG12412 - dTDP-glucose 4,6 dehydratase, NAD(P)-binding / TDP-glucose oxidoreductase-4,6 dehydratase RBB1_ECOLI, RFBB... - dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) - Escherichia coli, (P37759) dTDP-glucose 4,6-dehydratase... gi\|238861014, gi... - gi\|238901231\|ref\|YP_002927027.1\| dTDP-glucose 4,6 dehydratase, NAD(P)-binding [Escherichia coli BW29...	0.0	[6..343]	[2..337]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..345]	[4..341]

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Predicted Domain #1

Region A: Residues: [1-88]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MTTDTTVFVS GATGFIALHI MNDLLKAGYT VIGSGRSQEK NDGLLKKFNN NPKLSMEIVE 60 61 DIAAPNAFDE VFKKHGKEIK IVLHTASP [Run NCBI BLAST on this sequence.]
Region B: Residues: [99-130]	1 11 21 31 41 51 \| \| \| \| \| \| 1 DLLTPAVNGT KSILEAIKKY AADTVEKVIV TS [Run NCBI BLAST on this sequence.]
Region C: Residues: [173-198]	1 11 21 31 41 51 \| \| \| \| \| \| 1 KKFAEKTAWE FLKENKSSVK FTLSTI [Run NCBI BLAST on this sequence.]
Region D: Residues: [249-265]	1 11 21 31 41 51 \| \| \| \| \| \| 1 VSKAHLVAIE KPECTGQ [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.0
Match:	1keuA_
Description:	dTDP-glucose 4,6-dehydratase (RmlB)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A: Residues: [89-98]	1 11 21 31 41 51 \| \| \| \| \| \| 1 FHFETTNFEK [Run NCBI BLAST on this sequence.]
Region B: Residues: [131-172]	1 11 21 31 41 51 \| \| \| \| \| \| 1 STAALVTPTD MNKGDLVITE ESWNKDTWDS CQANAVAAYC GS [Run NCBI BLAST on this sequence.]
Region C: Residues: [199-209]	1 11 21 31 41 51 \| \| \| \| \| \| 1 NPGFVFGPQM F [Run NCBI BLAST on this sequence.]
Region D: Residues: [238-248]	1 11 21 31 41 51 \| \| \| \| \| \| 1 NYCGPFIDVR D [Run NCBI BLAST on this sequence.]
Region E: Residues: [266-276]	1 11 21 31 41 51 \| \| \| \| \| \| 1 RLVLSEGLFC C [Run NCBI BLAST on this sequence.]
Region F: Residues: [304-334]	1 11 21 31 41 51 \| \| \| \| \| \| 1 SFLEKNSCKF DNSKTKKLLG FQFYNLKDCI V [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.0
Match:	1keuA_
Description:	dTDP-glucose 4,6-dehydratase (RmlB)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [210-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADSLKHGINT SSGIVSELIH SKVGGEFY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [277-303]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEIVDILNEE FPQLKGKIAT GEPATGP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [335-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTAAQMLEVQ NEA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.0
Match:	1keuA_
Description:	dTDP-glucose 4,6-dehydratase (RmlB)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits