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View Structure Prediction Details

Protein: TOS8
Organism: Saccharomyces cerevisiae
Length: 276 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOS8.

Description E-value Query
Range
Subject
Range
TOS8 - Homeodomain-containing protein and putative transcription factor found associated with chromatin; ta...
gi|190407052 - gi|190407052|gb|EDV10319.1| homeobox protein TOS8 [Saccharomyces cerevisiae RM11-1a]
TOS8_YEAST - Homeobox protein TOS8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOS8 PE=3 SV=1
gi|151943712 - gi|151943712|gb|EDN62022.1| target of Sbf [Saccharomyces cerevisiae YJM789]
2.0E-51 [1..276] [1..276]
gi|13877513 - gi|13877513|gb|AAK43834.1|AF353092_1 BEL1-like homeobox 4 [Arabidopsis thaliana]
1.0E-38 [9..261] [240..491]
gi|13752407 - gi|13752407|gb|AAK38645.1|AF334758_1 homeodomain protein JUBEL1 [Hordeum vulgare subsp. vulgare]
2.0E-37 [2..269] [341..608]
gi|7239157 - gi|7239157|gb|AAF43095.1|AF053769_1 homeodomain protein [Malus x domestica]
4.0E-37 [2..264] [359..626]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-37 [46..271] [137..369]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTSIVNLNQ KIELPPIQVL FESLNRENET KPHFEERRLY QPNPSFVPRT NIAVGSPVNP  60
   61 VPVSSPVFFI GPSPQRSIQN HNAIMTQNIR QYPVIYNNNR EVISTGERNY IITVGGPPVT 120
  121 SSQPEYEHIS TPNFYQEQRL AQPHPVNESM MIGGYTNP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPISISRGKM LSGNISTNSV RGSNNGYSAK EKKHKAHGKR SNLPKATVSI LNKWLHEHVN  60
   61 NPYPTVQEKR ELLAKTGLTK LQISNWFINA RRRKIFSGQN DANNFRRKFS SSTNLAKF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.0
Match: 1b72B_
Description: pbx1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.77493186452261 bayes_pls_golite062009
DNA binding 1.66680362591419 bayes_pls_golite062009
binding 1.64929536290445 bayes_pls_golite062009
nucleic acid binding 1.62223670236121 bayes_pls_golite062009
transcription factor activity 1.03968483100366 bayes_pls_golite062009
sequence-specific DNA binding 0.10556378449224 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle