YRC Public Data Repository - Protein Structure Prediction

Protein:	ALK1
Organism:	Saccharomyces cerevisiae
Length:	760 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALK1.

Description	E-value	Query Range	Subject Range
ALK1_YEAST - Serine/threonine-protein kinase Haspin homolog ALK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 ... ALK1 - Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated ...	0.0	[1..760]	[1..760]
gi\|16197787 - gi\|16197787\|gb\|AAL13494.1\| GH01890p [Drosophila melanogaster]	0.0	[241..754]	[228..671]
gi\|322596, gi\|11... - gi\|6714479\|gb\|AAF26165.1\|AC008261_22 putative SNF1-related protein kinase [Arabidopsis thaliana], pi...	5.0E-99	[486..750]	[18..272]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	7.0E-99	[484..750]	[16..272]
gi\|7672782 - gi\|7672782\|gb\|AAF66639.1\|AF143743_1 SNF1 [Lycopersicon esculentum]	1.0E-98	[484..750]	[16..272]
gi\|4567091 - gi\|4567091\|gb\|AAD23582.1\|AF128443_1 SNF-1-like serine/threonine protein kinase [Glycine max]	6.0E-98	[484..750]	[17..273]

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Predicted Domain #1

Region A:
Residues: [1-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLHFDIVIQ LLSSHTLKSH QVEPPMDFET SFEEFVEDKR FIALEVSDND DDCDTDLTAD  60
   61 TADELESSAI LKMRESDASL NVTTGNNTSR KTTSNSKKRW SLLSNHSAVS SSKSKKRWSV 120
  121 LSSSFTSESH KDRESRNVLQ QKRKSLQSYS SLDTVASNSS ISASSSLKRS STGLSLRQLF 180
  181 TKIGINDDIS QPGIGIPQGK ENLPPTMGKK NSSIASTSSE NRLRTPLKPL VNHSKRPTSQ 240
  241 PQQQQPLYNA SLSSRRSSIS STVSSSSSSK WRFWKRNKNQ TPALLQPDHH SLKTFPAVNR 300
  301 RDSMTPVEPR NMVKHKTSFS DFHKTIFSSN TYSESSDTIS SMEITLKNKA SSSSLSLNVL 360
  361 KKRNSQSSLK HKSSHASLQK FKRNKGKSSM IAPSTATNSS NDDSCSYSSK NSTLSHRISL 420
  421 PVPDQVSRDK IQNKLRYSTS LLSLNSKSSL PMNK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [455-532]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDHDETLLRQ ILLNCDIKRI LNPAKGDVLP LINDVNHLSS IQLTSNVWQI GEVICKKVSL  60
   61 GTIDDITWDR KFLSLQEL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [551-567]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFVVKEANGG LYLYLLF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.69897
Match:	1cdkA_
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [533-550]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKLKIMQQKF DGIPQLLK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [568-760]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDHGTPISLI SLKNWKQILK IFWSCAGIIH GLEKNLKFEH RNLTLDNILI DGNGNITIID  60
   61 FKCSRLQTPQ DDVLYLRLDH PLFFLNGKDK SKINEYQYQF EFEIYQSMRI LLNMDASAFE 120
  121 PMTNLYWLYY LSRVLLKFGD RKLGKNDANR DKMARVINHL EMNLAVHKRG GQLFKRLETE 180
  181 DIKNTGDLLK LYK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.69897
Match:	1cdkA_
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein kinase activity	5.08693983533348	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	4.80278598786839	bayes_pls_golite062009
kinase activity	4.59756610116144	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.25355168820731	bayes_pls_golite062009
protein serine/threonine kinase activity	4.23864440079487	bayes_pls_golite062009
transferase activity	3.26787750561728	bayes_pls_golite062009
ATP binding	1.87003701072722	bayes_pls_golite062009
adenyl ribonucleotide binding	1.82650528610717	bayes_pls_golite062009
adenyl nucleotide binding	1.79644024762454	bayes_pls_golite062009
binding	1.69939147712641	bayes_pls_golite062009
purine ribonucleotide binding	1.56978145564551	bayes_pls_golite062009
ribonucleotide binding	1.56956819263374	bayes_pls_golite062009
purine nucleotide binding	1.54471996792105	bayes_pls_golite062009
nucleotide binding	1.53595022832543	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
protein binding	1.17747188575743	bayes_pls_golite062009
protein tyrosine kinase activity	1.17063753242103	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.05410128646972	bayes_pls_golite062009
receptor signaling protein activity	0.98751004123886	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.439470338563384	bayes_pls_golite062009
magnesium ion binding	0.0936583701619971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: