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View Structure Prediction Details

Protein: ATG18
Organism: Saccharomyces cerevisiae
Length: 500 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG18.

Description E-value Query
Range
Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [2..499] [903..1413]
gi|17225210 - gi|17225210|gb|AAL37301.1|AF323585_1 beta transducin-like protein HET-D2Y [Podospora anserina]
0.0 [1..499] [827..1296]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSPTINF INFNQTGTCI SLGTSKGFKI FNCEPFGKFY SEDSGGYAIV EMLFSTSLLA  60
   61 LVGIGDQPAL SPRRLRIIN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.887 0.209 protein targeting to vacuole b.1.18 E set domains
View Download 0.913 0.006 protein targeting to vacuole b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.902 0.003 protein targeting to vacuole b.48.1 mu transposase, C-terminal domain
View Download 0.829 0.003 protein targeting to vacuole b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.842 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.825 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.785 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.781 N/A N/A b.1.2 Fibronectin type III
View Download 0.774 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.767 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.764 N/A N/A b.84.1 Single hybrid motif
View Download 0.761 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.747 N/A N/A b.1.18 E set domains
View Download 0.746 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.742 N/A N/A b.7.2 Periplasmic chaperone C-domain
View Download 0.724 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.716 N/A N/A d.17.1 Cystatin/monellin
View Download 0.713 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.702 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.694 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.681 N/A N/A b.7.2 Periplasmic chaperone C-domain
View Download 0.673 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.670 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.662 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.662 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.661 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.660 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.654 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.647 N/A N/A b.7.2 Periplasmic chaperone C-domain
View Download 0.642 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.632 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.631 N/A N/A b.1.1 Immunoglobulin
View Download 0.630 N/A N/A b.60.1 Lipocalins
View Download 0.628 N/A N/A b.1.1 Immunoglobulin
View Download 0.626 N/A N/A b.60.1 Lipocalins
View Download 0.623 N/A N/A d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.622 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.615 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.610 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.610 N/A N/A b.1.18 E set domains
View Download 0.604 N/A N/A d.15.1 Ubiquitin-like
View Download 0.603 N/A N/A d.170.2 A heparin-binding domain
View Download 0.601 N/A N/A b.55.1 PH domain-like
View Download 0.601 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.600 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.597 N/A N/A b.5.1 alpha-Amylase inhibitor tendamistat
View Download 0.583 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.580 N/A N/A b.7.2 Periplasmic chaperone C-domain
View Download 0.576 N/A N/A b.7.2 Periplasmic chaperone C-domain
View Download 0.569 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.567 N/A N/A g.41.3 Zinc beta-ribbon
View Download 0.558 N/A N/A b.1.18 E set domains
View Download 0.554 N/A N/A b.1.20 Tp47 lipoprotein, middle and C-terminal domains
View Download 0.553 N/A N/A b.1.2 Fibronectin type III
View Download 0.548 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.547 N/A N/A d.15.1 Ubiquitin-like
View Download 0.544 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.535 N/A N/A b.1.18 E set domains
View Download 0.528 N/A N/A b.1.2 Fibronectin type III
View Download 0.514 N/A N/A b.1.1 Immunoglobulin
View Download 0.510 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.507 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.495 N/A N/A b.60.1 Lipocalins
View Download 0.494 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.481 N/A N/A b.71.1 Glycosyl hydrolase domain
View Download 0.477 N/A N/A b.43.4 Riboflavin synthase domain-like
View Download 0.468 N/A N/A b.40.6 MOP-like
View Download 0.467 N/A N/A b.40.2 Bacterial enterotoxins
View Download 0.467 N/A N/A d.82.1 Copper amine oxidase, domain N
View Download 0.466 N/A N/A b.1.2 Fibronectin type III
View Download 0.465 N/A N/A b.24.1 Hyaluronate lyase-like, C-terminal domain
View Download 0.458 N/A N/A b.1.1 Immunoglobulin
View Download 0.453 N/A N/A b.1.1 Immunoglobulin
View Download 0.450 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.447 N/A N/A d.88.1 SRF-like
View Download 0.445 N/A N/A b.1.1 Immunoglobulin
View Download 0.441 N/A N/A b.1.18 E set domains
View Download 0.441 N/A N/A b.61.2 Metalloprotease inhibitor
View Download 0.440 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.438 N/A N/A d.93.1 SH2 domain
View Download 0.432 N/A N/A b.34.9 Tudor/PWWP/MBT
View Download 0.427 N/A N/A b.1.1 Immunoglobulin
View Download 0.427 N/A N/A b.122.1 PUA domain-like
View Download 0.425 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.421 N/A N/A d.93.1 SH2 domain
View Download 0.417 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.415 N/A N/A d.74.2 C-terminal domain of arginine repressor
View Download 0.401 N/A N/A d.93.1 SH2 domain
View Download 0.396 N/A N/A b.34.9 Tudor/PWWP/MBT
View Download 0.388 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.386 N/A N/A b.55.1 PH domain-like
View Download 0.385 N/A N/A b.84.2 Rudiment single hybrid motif
View Download 0.383 N/A N/A d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.379 N/A N/A d.141.1 Ribosomal protein L6
View Download 0.379 N/A N/A b.1.2 Fibronectin type III
View Download 0.374 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.371 N/A N/A b.7.3 PHL pollen allergen
View Download 0.370 N/A N/A d.93.1 SH2 domain
View Download 0.358 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.358 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.355 N/A N/A b.1.1 Immunoglobulin
View Download 0.349 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.346 N/A N/A b.1.1 Immunoglobulin
View Download 0.343 N/A N/A d.131.1 DNA clamp
View Download 0.343 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.340 N/A N/A d.9.2 Description not found.
View Download 0.336 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.335 N/A N/A b.1.2 Fibronectin type III
View Download 0.333 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.333 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.327 N/A N/A b.60.1 Lipocalins
View Download 0.326 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.325 N/A N/A a.43.1 Met repressor-like
View Download 0.325 N/A N/A b.1.2 Fibronectin type III
View Download 0.324 N/A N/A c.55.4 Translational machinery components
View Download 0.319 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.312 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.310 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.308 N/A N/A b.1.18 E set domains
View Download 0.303 N/A N/A d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.297 N/A N/A b.24.1 Hyaluronate lyase-like, C-terminal domain
View Download 0.292 N/A N/A d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.292 N/A N/A b.60.1 Lipocalins
View Download 0.285 N/A N/A d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.281 N/A N/A b.1.11 PapD-like
View Download 0.279 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.279 N/A N/A b.84.1 Single hybrid motif
View Download 0.278 N/A N/A b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.278 N/A N/A b.40.6 MOP-like
View Download 0.278 N/A N/A b.1.18 E set domains
View Download 0.276 N/A N/A g.41.3 Zinc beta-ribbon
View Download 0.272 N/A N/A b.1.1 Immunoglobulin
View Download 0.272 N/A N/A b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.268 N/A N/A d.131.1 DNA clamp
View Download 0.267 N/A N/A b.1.1 Immunoglobulin
View Download 0.266 N/A N/A b.61.2 Metalloprotease inhibitor
View Download 0.263 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.262 N/A N/A b.1.18 E set domains
View Download 0.261 N/A N/A b.38.1 Sm-like ribonucleoproteins
View Download 0.261 N/A N/A b.60.1 Lipocalins
View Download 0.259 N/A N/A b.1.18 E set domains
View Download 0.256 N/A N/A b.34.5 Translation proteins SH3-like domain
View Download 0.256 N/A N/A c.55.4 Translational machinery components
View Download 0.256 N/A N/A b.60.1 Lipocalins
View Download 0.253 N/A N/A b.40.2 Bacterial enterotoxins
View Download 0.250 N/A N/A b.60.1 Lipocalins
View Download 0.235 N/A N/A b.60.1 Lipocalins
View Download 0.229 N/A N/A b.85.5 Tlp20, baculovirus telokin-like protein
View Download 0.226 N/A N/A d.93.1 SH2 domain
View Download 0.224 N/A N/A g.26.1 Antifungal protein (AGAFP)
View Download 0.220 N/A N/A b.85.5 Tlp20, baculovirus telokin-like protein
View Download 0.217 N/A N/A b.40.2 Bacterial enterotoxins
View Download 0.217 N/A N/A b.34.3 Myosin S1 fragment, N-terminal domain
View Download 0.208 N/A N/A g.41.3 Zinc beta-ribbon
View Download 0.207 N/A N/A b.85.5 Tlp20, baculovirus telokin-like protein
View Download 0.206 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.206 N/A N/A b.40.2 Bacterial enterotoxins
View Download 0.205 N/A N/A b.80.3 Cell-division inhibitor MinC, C-terminal domain
View Download 0.205 N/A N/A b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.204 N/A N/A b.1.18 E set domains

Predicted Domain #2
Region A:
Residues: [80-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKHSIICEV TFPTSILSVK MNKSRLVVLL QEQIYIYDIN TMRLLHTIET NP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.69897
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.8484919978091 bayes_pls_golite062009
protein binding 1.42618832381942 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
nucleic acid binding 0.624115832843391 bayes_pls_golite062009
substrate-specific transporter activity 0.479978536094414 bayes_pls_golite062009
hydrolase activity 0.36638536879917 bayes_pls_golite062009
cytoskeletal protein binding 0.359536347486199 bayes_pls_golite062009
signal transducer activity 0.343972561304413 bayes_pls_golite062009
molecular transducer activity 0.343972561304413 bayes_pls_golite062009
transcription regulator activity 0.282387003961579 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [132-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPRGLMAMSP SVANSYLVYP SPPKVINSEI KAHATTNNIT LSVGGNTETS FKRDQQDAGH  60
   61 SDISDLDQYS SFTKRDDADP TSSNGGNSSI IKNGDVIVFN LETLQPTMVI EAHKGEIAAM 120
  121 AISFDGTLMA TASDKGTIIR VFDIETGDKI YQFRRGTYAT RIYSISFSED SQYLAVTGSS 180
  181 KTVHIFKLGH SMSNNKLDSD DSNMEEAAAD DSSLDTTSID ALSDEENPTR LAREPYVDAS 240
  241 RKTMGRMIRY SSQKLSRRAA RTLGQIFPIK VTSLLESSRH FASLKLPVET NSHVMTISSI 300
  301 GSPIDIDTSE YPELFETGNS ASTESYHEPV MKMVPIRVVS SDGYLYNFVM DPERGGDCLI 360
  361 LSQYSILMD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle