YRC Public Data Repository - Protein Structure Prediction

Protein:	SHC1
Organism:	Saccharomyces cerevisiae
Length:	512 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SHC1.

Description	E-value	Query Range	Subject Range
SHC1_YEAST - Protein SHC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHC1 PE=2 SV=1 SHC1 - Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chi...	1.0E-99	[1..512]	[1..512]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	4.0E-73	[70..511]	[3..451]
CHR3_SCHPO - Chitin synthase regulatory factor 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=chr3 P... chr3 - chitin synthase regulatory factor Chr3	5.0E-63	[74..511]	[396..830]
HRD3A_ARATH - ERAD-associated E3 ubiquitin-protein ligase component HRD3A OS=Arabidopsis thaliana GN=HRD3A PE=1 SV...	1.0E-58	[108..507]	[43..424]
gi\|205330970, gi... - gi\|205330970\|gb\|EDZ17734.1\| sel1 repeat-containing family protein [Salmonella enterica subsp. enteri... gi\|197240807, gi... - gi\|197262552\|ref\|ZP_03162626.1\| Sel1 repeat family protein [Salmonella enterica subsp. enterica sero... gi\|161364492, gi... - gi\|161615128\|ref\|YP_001589093.1\| hypothetical protein SPAB_02896 [Salmonella enterica subsp. enteric... gi\|16764031, gi\|... - gi\|16764031\|ref\|NP_459646.1\| TPR repeat-containing protein [Salmonella typhimurium LT2], gi\|16419167... lcl\|NC_016856.1_... - [gene=ybeQ] [protein=hypothetical protein] [protein_id=YP_005236370.1] [location=complement(717574.....	7.0E-54	[160..507]	[2..316]

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Predicted Domain #1

Region A:
Residues: [1-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMTICSNTP GAYPEIGAYN EVDKQLESSG FSSDSSLILN KPEVRQYWSS VSSHISRSGD  60
   61 VFTNDKEKIS SSIGEDAMDI DASPSLIEKY NSFPTRKILP EQDEFENDVE DDASSSLKEK 120
  121 SQGSCEIEIA SEISSEILNG TSADGNSEFH DF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [153-336]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEPPPSQNES VALSFSQSND LDFLNNPSGS GSSNDINRST SSISLPRHVS LDFNVYNSLC  60
   61 LTNEVTASES HNVAKFHLGK KNKKSLLPRW KTIEMYGEVV KKTQDIYSNF QYAQYILRVG 120
  121 LDTEKLHELV KELEDESNSF SVDSLKEYLV NDAKVILKKL SAVGYPDAQY LLGDAYSSGV 180
  181 FGKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	1fchA_
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.736853224379565	bayes_pls_golite062009
protein binding	0.582813988794606	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [337-447]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNRRAFLLFS AAAKRMHIES VYRTAICYEC GLGVTRNAPK AVNFLTFAAT KNHPAAMYKL  60
   61 GVYSYHGLMG LPDDILTKMD GYRWLRRATS MASSFVCGAP FELANIYMTG Y

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	1fchA_
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [448-512]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLIISDPDY AMALYEKAAA LGHTESARIL EDARRSGGFV SRGHPPSAQK YHKTSHEAVA  60
   61 AKKLI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: