| Protein: | ISC1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 477 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISC1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..477] | [1..477] |
|
|
5.0E-73 | [108..463] | [1..347] |
|
|
7.0E-56 | [39..369] | [9..307] |
|
|
4.0E-55 | [39..369] | [9..307] |
|
|
5.0E-55 | [39..369] | [9..307] |
|
|
8.0E-49 | [20..344] | [277..592] |
|
|
8.0E-49 | [38..358] | [5..289] |
|
|
3.0E-48 | [24..344] | [21..333] |
|
Region A: Residues: [1-346] |
1 11 21 31 41 51
| | | | | |
1 MYNRKDRDVH ERKEDGQSEF EALNGTNAIM SDNSKAYSIK FLTFNTWGLK YVSKHRKERL 60
61 RAIADKLAGH SMLTPISDEL LPNGGDSNEN EDYDVIALQE IWCVEDWKYL ASACASKYPY 120
121 QRLFHSGILT GPGLAILSKV PIESTFLYRF PINGRPSAVF RGDWYVGKSI AITVLNTGTR 180
181 PIAIMNSHMH APYAKQGDAA YLCHRSCQAW DFSRLIKLYR QAGYAVIVVG DLNSRPGSLP 240
241 HKFLTQEAGL VDSWEQLHGK QDLAVIARLS PLQQLLKGCT TCDSLLNTWR AQRQPDEACR 300
301 LDYALIDPDF LQTVDAGVRF TERIPHLDCS VSDHFAYSCT LNIVPQ
|
| Detection Method: |  |
| Confidence: | 41.39794 |
| Match: | 1hd7A_ |
| Description: | DNA repair endonuclease Hap1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| inositol or phosphatidylinositol phosphatase activity | 3.64123197004285 | bayes_pls_golite062009 |
| phosphatidylinositol bisphosphate phosphatase activity | 3.0061663893933 | bayes_pls_golite062009 |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | 2.90758198006555 | bayes_pls_golite062009 |
| phosphoinositide 5-phosphatase activity | 2.90758198006555 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 2.26056838384313 | bayes_pls_golite062009 |
| hydrolase activity | 2.21673584332033 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 1.87742719915012 | bayes_pls_golite062009 |
| catalytic activity | 1.76511376991978 | bayes_pls_golite062009 |
| inositol-polyphosphate 5-phosphatase activity | 1.69034937361985 | bayes_pls_golite062009 |
| inositol trisphosphate phosphatase activity | 1.67310905470506 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 1.24865228320008 | bayes_pls_golite062009 |
| nuclease activity | 1.10772848766193 | bayes_pls_golite062009 |
| binding | 0.762705099992601 | bayes_pls_golite062009 |
| lipid phosphatase activity | 0.494223168454777 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity | 0.469778612465362 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity, producing 5'-phosphomonoesters | 0.466524009072462 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.414974033231176 | bayes_pls_golite062009 |
| exonuclease activity | 0.408287239827419 | bayes_pls_golite062009 |
| protein binding | 0.224287899263963 | bayes_pls_golite062009 |
| phosphatase activity | 0.00559251346312178 | bayes_pls_golite062009 |
| nucleic acid binding | 0.0053559034506292 | bayes_pls_golite062009 |
|
Region A: Residues: [347-477] |
1 11 21 31 41 51
| | | | | |
1 GTESRPSTSV KRAKTHDREL ILQRYSNYET MIECIHTYLK TAQRQKFFRG LHFWASILLL 60
61 IASLVVTTFT ANKAGWSSIF WVLFAIAVSI SGTIDGAISF LFGRSEIRAL IEVEQEVLDA 120
121 EHHLQTFLSE K
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.688 | a.74.1 | Cyclin-like |
| View | Download | 0.700 | a.29.2 | Bromodomain |
| View | Download | 0.543 | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.577 | a.63.1 | Apolipophorin-III |
| View | Download | 0.588 | a.5.4 | Elongation factor TFIIS domain 2 |
| View | Download | 0.700 | a.29.2 | Bromodomain |
| View | Download | 0.688 | a.74.1 | Cyclin-like |
| View | Download | 0.588 | a.5.4 | Elongation factor TFIIS domain 2 |
| View | Download | 0.577 | a.63.1 | Apolipophorin-III |
| View | Download | 0.543 | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.447 | a.60.10 | Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain |
| View | Download | 0.445 | a.5.3 | N-terminal domain of phosphatidylinositol transfer protein sec14p |
| View | Download | 0.441 | a.74.1 | Cyclin-like |
| View | Download | 0.441 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.437 | d.2.1 | Lysozyme-like |
| View | Download | 0.417 | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.401 | a.185.1 | Gametocyte protein Pfg27 |
| View | Download | 0.397 | a.74.1 | Cyclin-like |
| View | Download | 0.385 | a.148.1 | Arp2/3 complex 21 kDa subunit ARPC3 |
| View | Download | 0.382 | d.87.2 | CO dehydrogenase flavoprotein C-terminal domain-like |
| View | Download | 0.381 | a.74.1 | Cyclin-like |
| View | Download | 0.380 | c.53.1 | Resolvase-like |
| View | Download | 0.376 | a.24.4 | Hemerythrin |
| View | Download | 0.346 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.345 | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.336 | a.24.11 | Bacterial GAP domain |
| View | Download | 0.328 | d.192.1 | YlxR-like |
| View | Download | 0.310 | a.84.1 | Scaffolding protein gpD of bacteriophage procapsid |
| View | Download | 0.308 | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.307 | a.47.2 | t-snare proteins |
| View | Download | 0.302 | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.299 | a.72.1 | Functional domain of the splicing factor Prp18 |
| View | Download | 0.299 | a.26.1 | 4-helical cytokines |
| View | Download | 0.297 | a.24.1 | Apolipoprotein |
| View | Download | 0.293 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.289 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.270 | a.13.1 | alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 |
| View | Download | 0.269 | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.265 | b.40.4 | Nucleic acid-binding proteins |
| View | Download | 0.261 | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.251 | a.91.1 | Regulator of G-protein signalling, RGS |
| View | Download | 0.251 | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.248 | d.43.1 | Elongation factor Ts (EF-Ts), dimerisation domain |
| View | Download | 0.246 | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.245 | d.96.1 | Tetrahydrobiopterin biosynthesis enzymes-like |
| View | Download | 0.245 | a.24.11 | Bacterial GAP domain |
| View | Download | 0.242 | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.242 | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.240 | a.1.1 | Globin-like |
| View | Download | 0.238 | a.118.8 | TPR-like |
| View | Download | 0.237 | a.96.1 | DNA-glycosylase |
| View | Download | 0.236 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.235 | d.163.1 | DNA breaking-rejoining enzymes |
| View | Download | 0.234 | d.127.1 | Creatinase/aminopeptidase |
| View | Download | 0.232 | a.24.2 | Aspartate receptor, ligand-binding domain |
| View | Download | 0.232 | a.130.1 | Chorismate mutase II |
| View | Download | 0.227 | c.37.1 | P-loop containing nucleoside triphosphate hydrolases |
| View | Download | 0.227 | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.226 | a.73.1 | Retrovirus capsid protein, N-terminal core domain |
| View | Download | 0.224 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.219 | a.23.4 | Mitochondrial import receptor subunit Tom20 |
| View | Download | 0.216 | a.88.1 | LigA subunit of an aromatic-ring-opening dioxygenase LigAB |
| View | Download | 0.214 | d.129.3 | Bet v1-like |
| View | Download | 0.214 | a.118.8 | TPR-like |
| View | Download | 0.207 | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.206 | a.26.1 | 4-helical cytokines |
| View | Download | 0.203 | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
